Abstract: A device for detecting nucleic acids in a biological sample has a sample port, a lysis station and a sample conduit configured to mix a sample and lysis agent to form a sample-lysis mixture, pass the sample-lysis mixture across a solid-state membrane to capture nucleic acids in the biological sample therein, and receive the remainder of the sample-lysis mixture in a waste chamber. The wash station is configured to introduce the wash solution following the sample-lysis mixture, pass the wash solution across the solid-state membrane to purify nucleic acids captured therein, and receive the wash solution from the solid-state membrane in the waste chamber. The elution station is configured to pass the eluent across the solid-state membrane, elute captured nucleic acids from the solid-state membrane, and pass the captured nucleic acids into one or more reaction chambers for amplifying and detecting the captured nucleic acids.

Abstract: A device for amplifying and detecting nucleic acids in a biological sample has a sample port for receiving a biological sample, a solid-state membrane, a sample conduit, a lysis station, a wash station, an elution station, a waste chamber, and a reaction chamber. The sample port, lysis station and sample conduit are configured to mix a sample and lysis agent to form a sample-lysis mixture, pass the mixture across the solid-state membrane to capture nucleic acids in the sample therein, and receive the remainder of the mixture in the waste chamber. The wash station directs a wash solution across the solid-state membrane and into the waste chamber to purify nucleic acids captured in the membrane. The elution station directs an eluent across the membrane, elutes captured nucleic acids from the membrane, and passes the captured nucleic acids into the reaction chamber for amplifying and detecting the captured nucleic acids.

Abstract: A fluid ejection device and a printhead including one or more such fluid ejection devices are provided. The fluid ejection device includes a substrate having a first nozzle array and a second nozzle array, each array having a plurality of nozzles and being arranged along a first direction, the first nozzle array being arranged spaced apart in a second direction from the second nozzle array. A first fluid delivery pathway is in fluid communication with the first nozzle array, and a second fluid delivery pathway is in fluid communication with the second nozzle array. Nozzles of the first nozzle array have a first opening area and are arranged along the first nozzle array at a pitch P. Nozzles of the second nozzle array have a second opening area, the second opening area being less than the first opening area. At least one nozzle of the second array is arranged offset in the first direction from at least one nozzle of the first array by a distance which is less than pitch P.