Abstract: A light therapy device for treating a user's skin (such as wrinkles or acne). The device comprises a neckband for wearing on the user's neck and a light-emitting appliance comprising light diodes for delivering light therapy. Example formats for the light-emitting appliance include facemasks, eyemasks, and helmets. The device further comprises a power supply that may be contained within the neckband or carried by the neckband. An external electrical wire is for connecting the light-emitting appliance to the power supply. The neckband could have a variety of different configurations. Also disclosed are skin therapy kits and methods for light therapy to a user's skin.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of ?-synuclein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon. Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: There is provided a cleaning apparatus for the base of a toilet. The apparatus includes an inner peripheral portion for extending at least partially around the base of the toilet. The apparatus includes an outer peripheral portion spaced-apart from the inner peripheral portion. The apparatus includes an arcuate-shaped top portion extending from the inner peripheral portion to the outer peripheral portion. According to another aspect, there is provided a cleaning apparatus for the base of a toilet. The apparatus includes an absorbent member that is biased upwards and which may be selectively lowered to abut a location adjacent to the base of the toilet for absorbing fluid.

Abstract: Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are nucleoside phosphonates and esters thereof.

Abstract: A specially engineered composite fiber is provided that is a combination of weight imparting particles and polymeric compounds, with a specific gravity totaling about 2 or greater. The composite fiber can be extruded and melt-spun like a normal polymeric fiber, thus creating a relatively heavy, weighted material fiber, sheet or fabric.

Abstract: Lipid-modified phosphodiester nucleoside prodrugs are described herein. The prodrugs can be used to treat viral infections and cancer.

Abstract: Leptomycin-type compounds according to formula I wherein R0, R1, R2, R10, R11, R12, R13, R14, and m are as defined herein, exhibit anti-tumor activity.

Abstract: Leptomycin-type compounds according to Formula I wherein R0, R1, R2, R10, R11, R12, R13, R14, and m are as defined herein, exhibit anti-tumor activity.

Abstract: Leptomycin-type compounds according to Formula I wherein R0, R1, R2, R10, R11, R12, R13, R14, and m are as defined herein, exhibit anti-tumor activity.

Abstract: The present invention provides 14-methyl epothilone compounds, along with intermediates thereto, methods for their preparation, compositions comprising the compounds, and methods for their use in the treatment of cancer and other diseases and conditions characterized by undesired cellular hyperproliferation.