Patents by Inventor Steven E. Hall

Steven E. Hall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment in thrombolytic disease
    Patent number: 4560698
    Abstract: 7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein p is 0 to 4; A is CH.dbd.CH, (CH.sub.2).sub.2, or a single bond; m is 0 to 8; R is H, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane; n is 1 to 4; n' is 0, 1 or 2; q is 1 to 12; X is ##STR2## wherein R.sup.2 and R.sup.3 may be the same or different and are H or lower alkyl; t is 0 to 5; and R.sup.1 is H, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, and including all stereoisomers thereof.The compounds are cardiovascular agents and antiinflammatory agents useful, for example, in the treatment of thrombolytic disease, inflammation and pain.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: December 24, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted thio prostaglandin analogs and their use in the treatment of thrombolytic disease
    Patent number: 4555523
    Abstract: 7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl, X is O, S or NH, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2, p is 0 to 4, n is 1 to 4, n' is 0 to 2, q is 1 to 4 and m is 0 to 8, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease; and are antiinflammatory agents useful, for example, in the treatment of rheumatoid arthritis.
    Type: Grant
    Filed: June 4, 1984
    Date of Patent: November 26, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted ethers and their use in treating thrombolytic disease
    Patent number: 4550120
    Abstract: 7-Oxabicycloheptane substituted ether prostaglandin analogs are provided having the structural formula ##STR1## wherein A is O or ##STR2## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: April 30, 1984
    Date of Patent: October 29, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Jagabandhu Das, Steven E. Hall
  • 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
    Patent number: 4542157
    Abstract: 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R.sup.1 is hydrogen, lower alkyl, aryl, aralkyl, cycloalkyl or cycloalkylalkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, y is 0 to 4, m is 0 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof.The compounds are antiinflammatory agents useful, for example, in the treatment of inflammatory diseases and analgesic agents as well as cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: September 17, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted oxa prostaglandin analogs and their use in the treatment of thrombolytic disease
    Patent number: 4526900
    Abstract: 7-Oxabicycloheptane substituted oxo prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl, alkali metal or tris(hydroxymethyl)aminomethane, R.sup.1 and R.sup.2 may be the same or different and are hydrogen or lower alkyl, R.sup.3 is hydrogen, lower alkyl, aryl or cycloalkyl, A is --CH.dbd.CH-- or --(CH.sub.2).sub.2 --, m is 1 to 8, and n is 1 to 4, p is 1 to 12 and q is 0 to 5, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: January 26, 1984
    Date of Patent: July 2, 1985
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted thio prostaglandin analogs useful in treating platelet aggregation and bronchoconstriction
    Patent number: 4474803
    Abstract: 7-Oxabicycloheptane substituted thio prostaglandin analogs are provided having the structural formula ##STR1## wherein R is hydrogen, lower alkyl or alkali metal, R.sup.1 is lower alkyl, arylalkyl, aryl, cycloalkyl or cycloalkylalkyl. A is --CH.dbd.CH or --(CH.sub.2).sub.2, n is 1 to 4, n' is 0 to 2 and m is 1 to 8, and including all stereoisomers thereof.The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: October 2, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Martin F. Haslanger
  • 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
    Patent number: 4456616
    Abstract: 7-Oxabicycloheptane substituted amino prostaglandin analogs are provided having the structural formula ##STR1## and including all stereoisomers thereof. The compounds are cardiovascular agents useful, for example, in the treatment of thrombolytic disease.
    Type: Grant
    Filed: December 27, 1982
    Date of Patent: June 26, 1984
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Martin F. YHaslanger, Masami Nakane, Steven E. Hall