Abstract: Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.

Abstract: Methods are disclosed for identifying antibacterial compounds which inhibit propagation of selected spectrum bacteria, which bacteria use specific tRNA to code for Ala, Met, Ser, or Leu that other bacteria do not use. In one embodiment, the selected spectrum bacteria use GCA to code for Ala, whereas other bacteria use a different codon to code for alanine. The methods involve determining whether putative inhibitors promote or inhibit complex formation between the tRNA and a bacterial ribosome, or between the tRNA and an aminoacyl synthetase. Compounds which promote or inhibit complex formation can disrupt protein production, which bacteria need to propagate. The identified antibacterial compounds can selectively inhibit bacterial propagation. By limiting their effects to the selected spectrum bacteria, these compounds can treat or prevent specific bacterial infections without disrupting the normal bacterial flora, the patients' microbiome, or causing antibacterial resistance.

Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.

Abstract: Inhibitors of retroviral propagation, methods of treatment and prevention of retroviral infections using the inhibitors, and pharmaceutical compositions including the inhibitors, are disclosed.

Abstract: Devices and methods for centering an intravascular filter within a blood vessel are disclosed. A filter system in accordance with an exemplary embodiment of the present invention may include an intravascular filter, a filter sheath adapted to contain the intravascular filter, and a centering member adapted to assume a preset shape when deployed within a blood vessel. The centering member may comprise an elongated wire having a hoop section adapted to radially expand against the inner wall of the blood vessel when deployed. In some embodiments, multiple centering members can be employed to facilitate centering of both the intravascular filter and the filter sheath within the blood vessel, if desired.

Abstract: An automatic telephone scheduling system (20) includes a data server (22), a dial server (24), and a plurality of agent workstations (28) which communicate with each other through messages transmitted over a local area network (30). The data server (22) has stored in its memory a plurality of account information records to be utilized for one or more calling campaigns. The dial server (24) includes an independent intelligent processor (80) which functions as a master to the data server (22) but as a slave to the agent workstations (28). The dial server (24) further includes a plurality of audio MUXes (88) and dialers (90) for automatically dialing and connecting calls to the agent workstations (28). In various embodiments, a plurality of data servers and/or a plurality of dial servers are employed.