Abstract: Systems and methods are provided for use in facilitating donation transactions to payment accounts. One exemplary method includes soliciting, by a computing device, a selection of a charity for a donation transaction, via an application programming interface (API), at a network-based interface affiliated with an issuer, in response to a donate input from a user authenticated to the network-based interface, and soliciting, by the computing device, a donation detail for the donation transaction, via the API, from the user. The method also includes, in response to the selection of the charity and the donation detail, identifying, by the computing device, in a user data structure, the payment account associated with the user and the issuer. And, the method further includes compiling an authorization request for the donation transaction based on the identified payment account and transmitting the authorization request to the issuer.