Patents by Inventor Steven Estus

Steven Estus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9066928
    Abstract: The presently-disclosed subject matter includes methods for treating Alzheimer's disease in a subject. The subject can have Alzheimer's diseases, can be identified has being at risk for developing Alzheimer's disease, or both. The method can comprise administering a composition that includes a CD33 inhibitor, which may include a CD33 antibody. In some embodiments the composition can further comprise at least one additional component useful for treating Alzheimer's disease. The presently-disclosed subject matter also includes compositions and kits for treating Alzheimer's disease in a subject.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: June 30, 2015
    Assignee: University of Kentucky Research Foundation
    Inventors: Steven Estus, Manasi Malik, James Simpson
  • Publication number: 20080131432
    Abstract: This invention is related to a novel method of treating the chemotoxic effects on the central nervous system of chemotherapeutic drugs, namely Adriamycin, by administering a therapeutically effective amount of anti-Tumor Necrosis Factor-? antibody to a patient to alleviate the symptoms of the effects. The antibody operates to decrease the serum level of Tumor Necrosis Factor-?, prevents the p53 translocation to mitochondria and prevents the decline in mitochondrial respiration of brain tissues and thereby relieves the symptoms of somnolence caused by chemotherapeutic drugs.
    Type: Application
    Filed: June 28, 2007
    Publication date: June 5, 2008
    Applicant: University of Kentucky Research Foundation
    Inventors: Jitbanjong Tangpong, Daret St. Clair, Allan Butterfield, Mary Vore, Steven Estus, William St. Clair