Abstract: Liquid-transfer apparatus, and methodology employing the same, operatively interposable a syringe and a vial, and accommodating both a single-mouth-size (single-size), two-vial transfer procedure, and a two-mouth-size (two-size), two-vial transfer procedure. The apparatus includes a liquid-transfer device having a syringe-coupling end, a vial-coupling end, and liquid-passage structure effectively communicating between these ends. In the case of accommodating a single-mouth-size (single-size), two-vial procedure, only the liquid-transfer device is employed, and the same is sized with a vial-coupling end that is constructed for direct coupling to the top of the single-size vial which is used.

Abstract: An ampule filling device having an ampule for jet injection attached to a transfer apparatus having a housing, a barrier within the housing, and a push rod attached to the housing to drive the medication from a medication vial. Further, the ampule filling device is advantageously bulk sterilized during assembly, and, assembled and packaged in an aseptic manufacturing environment.

Abstract: A needleless injection device includes an initiator valve controlling flow of compressed gas into a reservoir. A poppet valve connecting to the reservoir has a gas pressure regulation end to regulate flow from the initiator valve into the reservoir. A clamp piston is driven forward by gas pressure from the reservoir and causes jaws to clamp onto a plunger extending into an ampule. The poppet valve opens when reservoir pressure reaches the cracking pressure of the poppet valve. Gas from the reservoir rushes through the poppet valve into a drive chamber and forces a drive piston, containing the clamp piston and jaws, forward causing the plunger to slide into the ampule. A jet of injectant is discharged from the nozzle of the ampule and penetrates through the patient's skin. An improved method of needleless injection uses a specific pressure profile, ampule nozzle diameter, patient, injection site, and injectant parameters.

Abstract: A needleless injection device includes an initiator valve controlling flow of compressed gas into a reservoir. A poppet valve connecting to the reservoir has a gas pressure regulation end to regulate flow from the initiator valve into the reservoir. A clamp piston is driven forward by gas pressure from the reservoir and causes jaws to clamp onto a plunger extending into an ampule. The poppet valve opens when reservoir pressure reaches the cracking pressure of the poppet valve. Gas from the reservoir rushes through the poppet valve into a drive chamber and forces a drive piston, containing the clamp piston and jaws, forward causing the plunger to slide into the ampule. A jet of injectant is discharged from the nozzle of the ampule and penetrates through the patient's skin. An improved method of needleless injection uses a specific pressure profile, ampule nozzle diameter, patient, injection site, and injectant parameters.

Abstract: A needless injection device includes an initiator valve controlling flow of compressed gas into a reservoir. A poppet valve connecting to the reservoir has a gas pressure regulation end to regulate flow from the initiator valve into the reservoir. A clamp piston is driven forward by gas pressure from the reservoir and causes jaws to clamp onto a plunger extending into an ampule. The poppet valve opens when reservoir pressure reaches the cracking pressure of the poppet valve. Gas from the reservoir rushes through the popper valve into a drive chamber and forces a drive piston, containing the clamp piston and jaws, forward causing the plunger to slide into the ampule. A jet of injectant sprays out of the nozzle of the ampule and penetrates through the patient's skin.

Abstract: A method and mold for making an ampule for a needleless or jet injector device. The tip of a core pin is guided into a clearance hole sufficiently large to prevent the tip from hitting the mold cavity. Plastic is injected into the mold and flows into the space between the core pin tip and the clearance hole forming a vestigial nozzle pilot cylinder around and over the ampule nozzle. The ampule is removed from the mold and the vestigial nozzle pilot cylinder is removed to form a finished ampule. A core pin tip is made of drawn wire or is separately replaceable on the core pin. A nozzle of an ampule is cast in place. An ampule is molded with an enlarged nozzle and a separate orifice is installed in the ampule to provide the desired nozzle opening.