Abstract: Disclosed is an isolated or purified T cell receptor (TCR) having antigenic specificity for mutated human p53. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions are also provided. Also disclosed are methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal.

Abstract: Disclosed are methods of preparing an isolated population of dendritic cells, isolated populations of dendritic cells prepared by the methods, and pharmaceutical compositions comprising the isolated population of dendritic cells. Also disclosed are methods of treating or preventing cancer using the isolated population of dendritic cells or pharmaceutical compositions.

Abstract: A valve assembly is provided for controlling the flow of liquid accumulated in a closed vessel through a drain port in the bottom wall of the vessel. The assembly includes a body member having a first section disposed within the drain port. The body member has a second section extending outwardly from the first section. The first and second sections are provided with a first passage for air venting the vessel interior, a second passage for controlled draining of the accumulated liquid from the vessel interior, and a common opening, the latter having an exposed end. Adjustably mounted on the body member is a valve member having a first segment adjustably disposed with respect to the opening of the body member and a second segment projecting outwardly from the first segment and subtending the body member second section. The valve member second segment is provided with first and second passages corresponding with the first and second passages of the body member.