Abstract: A flow measuring system for one or more oil nozzles of a lubrication system of an aircraft engine comprises an external supply of a testing liquid and a pump fluidly connecting the external supply of the testing liquid to an inlet of the lubrication system via a first conduit. The inlet to the lubrication system is disposed upstream of the one or more oil nozzles. A second conduit fluidly connects an outlet of the lubrication system to the external supply of the testing liquid. The outlet of the lubrication system is disposed downstream of the one or more oil nozzles. A flow measuring device is operable to measure a flow resistance through the one or more oil nozzles.

Abstract: A flow measuring system for one or more oil nozzles of a lubrication system of an aircraft engine comprises an external supply of a testing liquid and a pump fluidly connecting the external supply of the testing liquid to an inlet of the lubrication system via a first conduit. The inlet to the lubrication system is disposed upstream of the one or more oil nozzles. A second conduit fluidly connects an outlet of the lubrication system to the external supply of the testing liquid. The outlet of the lubrication system is disposed downstream of the one or more oil nozzles. A flow measuring device is operable to measure a flow resistance through the one or more oil nozzles.

Abstract: We describe a high-throughput, phenotypic screening method for one or more modulator(s) of Apolipoprotein B (ApoB) in larval zebrafish. The modulator(s) may be enhancers or inhibitors of ApoB expression. This represents a remarkable opportunity to investigate drug targets in every cell and tissue type of a whole animal without bias, thus maximizing the likelihood of identifying viable pre-therapeutic leads for compounds or biologics in a subject (e.g., human).

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or cholesterol processing in a vertebrate; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism in the vertebrate.

Abstract: An exhaust duct for directing a stream of combustion gases in a gas turbine engine is provided. The exhaust duct comprises an inlet for receiving the stream of combustion gases from a turbine section of the gas turbine engine; an outlet in fluid communication with the inlet; and a transition portion defining a passage between the inlet and the outlet. The passage comprises a discontinuous annular region having a first side portion and a second side portion that are separated by a flow splitter. At least one bypass channel interconnects the first side portion and the second side portion of the discontinuous annular region.

Abstract: An exhaust duct for directing a stream of combustion gases in a gas turbine engine is provided. The exhaust duct comprises an inlet for receiving the stream of combustion gases from a turbine section of the gas turbine engine; an outlet in fluid communication with the inlet; and a transition portion defining a passage between the inlet and the outlet. The passage comprises a discontinuous annular region having a first side portion and a second side portion that are separated by a flow splitter. At least one bypass channel interconnects the first side portion and the second side portion of the discontinuous annular region.

Abstract: An exhaust duct for directing a stream of exhaust gases in a gas turbine engine is provided. The exhaust duct comprises an inlet for receiving the stream of exhaust gases from a turbine section of the gas turbine engine; an outlet in fluid communication with the inlet; and a transition portion defining a passage between the inlet and the outlet. The passage comprises an annular region having a first side portion and a second side portion that are separated by a flow splitter. At least one bypass channel interconnects the first side portion and the second side portion of the annular region.

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid and/or cholesterol processing in a vertebrate; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism in the vertebrate.

Abstract: An exhaust duct for directing a stream of exhaust gases in a gas turbine engine is provided. The exhaust duct comprises an inlet for receiving the stream of exhaust gases from a turbine section of the gas turbine engine; an outlet in fluid communication with the inlet; and a transition portion defining a passage between the inlet and the outlet. The passage comprises an annular region having a first side portion and a second side portion that are separated by a flow splitter. At least one bypass channel interconnects the first side portion and the second side portion of the annular region.

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.

Abstract: The present invention is directed to a method for the lowering of levels of LDL cholesterol in an individual comprising administering to the individual an agent which modulates the activity of the protein annexin 2, cyclophilin A, cyclophilin 40, or HSP 56 or the complex of annexin 2 and caveolin I, in the intestinal cells of the individual.

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism. The present invention is a mutant fish containing a metabolic defect affecting phospholipid and cholesterol processing. The mutant fish is useful for studying phospholipid and cholesterol metabolism and for screening compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.

Abstract: The present invention utilizes fluorescent lipids, particularly quenched phospholipid or cholesterol analogues, to facilitate screening for phenotypes representing perturbations of lipid processing; screening for genetic mutations that lead to disorders of phospholipid and/or cholesterol metabolism; and screening of compounds designed to treat disorders of phospholipid and/or cholesterol metabolism.