Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery.

Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery.

Abstract: A memory system and method for storing data in one or more storage chips includes: one or more memory cards each having a plurality of storage chips, and each chip having a plurality of dies having a plurality of memory cells; a memory controller comprising a translation module, the translation module further comprising: a logical to virtual translation table (LVT) having a plurality of entries, each entry in the LVT configured to map a logical address to a virtual block address (VBA), where the VBA corresponds to a group of the memory cells on the one or more memory cards, wherein each entry in the LVT further includes a write wear level count to track the number of writing operations to the VBA, and a read wear level count to track the number of read operations for the VBA mapped to that LVT entry.

Abstract: A hybrid structural assembly includes a vehicle structural member extending from a first end to a second end, and a composite reinforcement member attached to the vehicle structural member between the first and second ends of the vehicle structural member. The composite reinforcement member being formed by a continuous method and cut to a predetermined length extending from the first end to the second end.

Abstract: A roof rack assembly for a vehicle includes a pedestal including an indentation. A roof rail is movable between a first configuration and a second configuration relative to the pedestal. In the first configuration, a toggle loop of the roof rail is positioned in a first orientation relative to the indentation. In the second configuration, the toggle loop is positioned in a second orientation relative to the indentation.

Abstract: A sun visor assembly for a vehicle that includes a mount configured to be connected to the vehicle. A guide rod having a first portion that includes a head and a second portion with a terminal end is operably coupled to the mount via the head. An impact point is at the terminal end of the second portion. The guide rod and the impact point are configured for use as a window breaker tool in a disassembled position. A visor is operably coupled to the guide rod in an assembled position and is rotatable about the guide rod from a first position to a second position. The visor includes a channel defined within the visor that is configured to receive the guide rod.

Abstract: An automotive panel assembly according to an exemplary aspect of the present disclosure includes a first panel, a second panel, and a flange of the first panel folded over an edge region of the second panel to hem together the first and second panels. The flange of the first panel includes a textured geometry that interlocks with a textured geometry of the edge region.

Abstract: A battery box for an electric vehicle includes an Al casting that extends between and joins to a BIW or chassis rails of the electric vehicle. The Al casting includes a bottom wall, a side wall with a pair of rails that are securely attached to the BIW or chassis rails of the vehicle, and a plurality of cross members. The bottom wall, the side wall, and the plurality of cross members define a structural enclosure with a plurality of battery compartments and at least one crush zone, and the structural enclosure is load bearing member of the electric vehicle.

Abstract: A part includes a sheet metal component having a predefined shape and at least one additively manufactured reinforcement deposited on, metallurgically bonded to, and extending along a surface of the sheet metal component. The at least one additively manufactured reinforcement can be a directed energy deposition (DED) reinforcement rib. Also, the at least one additively manufactured reinforcement can be deposited on the piece of sheet metal before the piece of sheet metal is formed into the predefined shape, or in the alternative, the at least one additively manufactured reinforcement can be deposited on the piece of sheet metal after the piece of sheet metal is formed into the predefined shape.

Abstract: Accurate tissue segmentation is performed without a priori knowledge of tissue type or other extrinsic information not found within the subject image, and may be combined with classification analysis so that diseased tissue is not only delineated within an image but also characterized in terms of disease type. In various embodiments, a source image is decomposed into smaller overlapping subimages such as square or rectangular tiles, which are sifted based on a visual criterion. The visual criterion may be one or more of image entropy, density, background percentage, or other discriminator. A convolutional neural network produces tile-level classifications that are aggregated to produce a tissue segmentation and, in some embodiments, to classify the source image or a subregion thereof.

Abstract: Large digital images are classified by analyzing them at a subimage level and assigning classification probabilities to the subimages; these may be combined into a classification probability for the entire image. Classification probabilities may be visualized across the image using probabilities computed for the subimages. This enables ready identification of the image subregions upon which classification is based as well as the classification scores or probabilities associated therewith. For example, a large source image—too large to be analyzed directly by a neural network—may be decomposed into smaller subimages such as square tiles, which are sifted based on a visual criterion. The visual criterion may be image entropy, density, background percentage, or other discriminator. A neural network produces tile-level classifications that are aggregated to classify the source image, and overlapping tiles are used to create a probability map showing subimage probabilities.

Abstract: An automotive panel assembly includes, among other things, a first panel, a second panel, a flange of the first panel folded over an edge region of the second panel to hem together the first and second panel, and a dimple of the flange extending into an aperture within the edge region of the second panel. At least a portion of the aperture is exposed.

Abstract: An automotive panel assembly according to an exemplary aspect of the present disclosure includes a first panel, a second panel, and a flange of the first panel folded over an edge region of the second panel to hem together the first and second panels. The flange of the first panel includes a textured geometry that interlocks with a textured geometry of the edge region.

Abstract: A method of determining battery degradation retroactively using historical data is disclosed. The method includes the steps of collecting state of charge (SOC) and DC ampere data for a predetermined time period; determining a delta (?) SOC based on the data collected; creating a set of SOC regimes having a size based on ?SOC; filtering the SOC data and determining a set of points which indicate a charging or discharging event; and calculating overall Coulombs associated with each charging or discharging event and for each event, producing a timestamp and Coulombs associated with each event.

Abstract: An automotive panel assembly includes, among other things, a first panel, a second panel, a flange of the first panel folded over an edge region of the second panel to hem together the first and second panel, and a dimple of the flange extending into an aperture within the edge region of the second panel. At least a portion of the aperture is exposed.

Abstract: Methods, systems, and apparatuses for the accelerated aging of beverages, including distilled spirits are disclosed. A spirit is aged through a modular approach that targets development of individual sensory characteristics. In one embodiment, a spirit undergoes ultrasonic cavitation in the presence of wood chips, heating in the presence of wood chips, ultrasonic cavitation without wood chips, heating without wood chips, and intermittent aeration. The process is operable to produce a highly customized spirit and achieve a taste, bouquet, and color similar to that of traditionally aged spirits.

Abstract: Methods, systems, and apparatuses for the accelerated aging of beverages, including distilled spirits are disclosed. A spirit is aged through a modular approach that targets development of individual sensory characteristics. In one embodiment, a spirit undergoes ultrasonic cavitation in the presence of wood chips, heating in the presence of wood chips, ultrasonic cavitation without wood chips, heating without wood chips, and intermittent aeration. The process is operable to produce a highly customized spirit and achieve a taste, bouquet, and color similar to that of traditionally aged spirits.

Abstract: Large digital images are classified by analyzing them at a subimage level and assigning classification probabilities to the subimages; these may be combined into a classification probability for the entire image. Classification probabilities may be visualized across the image using probabilities computed for the subimages. This enables ready identification of the image subregions upon which classification is based as well as the classification scores or probabilities associated therewith. For example, a large source image—too large to be analyzed directly by a neural network—may be decomposed into smaller subimages such as square tiles, which are sifted based on a visual criterion. The visual criterion may be image entropy, density, background percentage, or other discriminator. A neural network produces tile-level classifications that are aggregated to classify the source image, and overlapping tiles are used to create a probability map showing subimage probabilities.

Abstract: Methods, systems, and apparatuses for the accelerated aging of beverages, including distilled spirits are disclosed. A spirit is aged through a modular approach that targets development of individual sensory characteristics. In one embodiment, a spirit undergoes ultrasonic cavitation in the presence of wood chips, heating in the presence of wood chips, ultrasonic cavitation without wood chips, heating without wood chips, and intermittent aeration. The process is operable to produce a highly customized spirit and achieve a taste, bouquet, and color similar to that of traditionally aged spirits.

Abstract: A device for securing a movable panel relative to a vehicle body includes a housing, a plunger, a handle, and a spring. The housing defines a bore and a slot. The plunger includes a shaft and a clamp extending radially outward from the shaft. The shaft extends through the bore and is coupled to the housing for relative axial and rotational movement relative to the housing. The handle is fixedly coupled to the shaft and extends through the slot. The spring biases the clamp toward the housing.