Abstract: The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms made by these processes. The embodiments of the present invention further provide for the preparation of lasmiditan acetate, 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide acetate salt, and/or pharmaceutical compositions thereof, and/or uses of lasmiditan acetate and formulations thereof in subcutaneous drug delivery.

Abstract: Accurate tissue segmentation is performed without a priori knowledge of tissue type or other extrinsic information not found within the subject image, and may be combined with classification analysis so that diseased tissue is not only delineated within an image but also characterized in terms of disease type. In various embodiments, a source image is decomposed into smaller overlapping subimages such as square or rectangular tiles, which are sifted based on a visual criterion. The visual criterion may be one or more of image entropy, density, background percentage, or other discriminator. A convolutional neural network produces tile-level classifications that are aggregated to produce a tissue segmentation and, in some embodiments, to classify the source image or a subregion thereof.

Abstract: Analysis of magnetic resonance (MR) images for identifying objects such as organs and radioactive seeds is improved through image pre-processing and post-processing techniques. With pre-processing, MR image data is analyzed to identify a set of biased image units. The image unit may be a voxel or a pixel. These biased image units are removed and replaced with image units having a random distribution centered around a specified value. The replacement image units approximate noise and reduce bias that may affect the image analysis. The post-processing techniques involve handling the results of multiple machine learning models. Each image unit is evaluated by multiple machine learning models. The probability of the image unit as corresponding to a particular object based on all machine learning models is determined. The particular object may be displayed based on the determined probability.

Abstract: Methods, systems, and apparatuses for the accelerated aging of beverages, including distilled spirits are disclosed. A spirit is aged through a modular approach that targets development of individual sensory characteristics. In one embodiment, a spirit undergoes ultrasonic cavitation in the presence of wood chips, heating in the presence of wood chips, ultrasonic cavitation without wood chips, heating without wood chips, and intermittent aeration. The process is operable to produce a highly customized spirit and achieve a taste, bouquet, and color similar to that of traditionally aged spirits.

Abstract: Methods and systems for representing a tissue segmentation from a source digital image computationally generate, from a source digital image of an anatomic region, a digital tissue segmentation visually indicating regions of interest corresponding to an abnormal condition associated with at least portions of the anatomic region. The source image and the tissue segmentation may be alternately displayed in registration on a mobile device at a gesturally selected magnification level.

Abstract: Methods, systems, and apparatuses for the accelerated aging of beverages, including distilled spirits are disclosed. A spirit is aged through a modular approach that targets development of individual sensory characteristics. In one embodiment, a spirit undergoes ultrasonic cavitation in the presence of wood chips, heating in the presence of wood chips, ultrasonic cavitation without wood chips, heating without wood chips, and intermittent aeration. The process is operable to produce a highly customized spirit and achieve a taste, bouquet, and color similar to that of traditionally aged spirits.

Abstract: First and second predictors are used to identify regions of interest in a medical image. The first predictor is configured to maximize precision in identifying one or more abnormalities that it was trained to recognize, or at least to have greater precision than the second predictor. The second predictor is configured or selected to maximize sensitivity (i.e., recall) in identifying one or more abnormalities that it was trained to recognize, or at least to have greater sensitivity than the first predictor. The predictions of the first and second predictors may be used to create a digital map image showing the locations of regions of interest identified by the first and second predictors. Alternatively or in addition, the predictions may be used to rank images or image sets in terms of review priority.

Abstract: A battery box for an electric vehicle includes an Al casting that extends between and joins to a BIW or chassis rails of the electric vehicle. The Al casting includes a bottom wall, a side wall with a pair of rails that are securely attached to the BIW or chassis rails of the vehicle, and a plurality of cross members. The bottom wall, the side wall, and the plurality of cross members define a structural enclosure with a plurality of battery compartments and at least one crush zone, and the structural enclosure is load bearing member of the electric vehicle.

Abstract: A vehicle roof structure of a vehicle includes an outer roof panel and a single, unitized inner roof panel. The inner roof panel is separate from the outer roof panel and is secured to the outer roof panel. The inner roof panel includes a plurality of roof headers, a roof bow, and support braces. The roof headers are spaced apart from each other and extend in a transverse direction relative to a longitudinal direction of the vehicle. The roof bow is spaced apart from and positioned between two roof headers of the plurality of roof headers and extends in the transverse direction. Each support brace is positioned between the roof bow and one of the two roof headers. The support braces extend from the roof bow to the one of the two roof headers and extend in multiple directions.

Abstract: Methods and systems for representing a tissue segmentation from a source digital image computationally generate, from a source digital image of an anatomic region, a digital tissue segmentation visually indicating regions of interest corresponding to an abnormal condition associated with at least portions of the anatomic region. The source image and the tissue segmentation may be alternately displayed in registration on a mobile device at a gesturally selected magnification level.

Abstract: A roof rack assembly for a vehicle includes a pedestal including an indentation. A roof rail is movable between a first configuration and a second configuration relative to the pedestal. In the first configuration, a toggle loop of the roof rail is positioned in a first orientation relative to the indentation. In the second configuration, the toggle loop is positioned in a second orientation relative to the indentation.

Abstract: A hybrid structural assembly includes a vehicle structural member extending from a first end to a second end, and a composite reinforcement member attached to the vehicle structural member between the first and second ends of the vehicle structural member. The composite reinforcement member being formed by a continuous method and cut to a predetermined length extending from the first end to the second end.

Abstract: A traction battery pack for an electrified vehicle may include a protection bracket for shielding a vent feature of the traction battery pack. An exemplary protection bracket may be made of a polymeric material and is designed to shield the vent feature from debris impingement. The protection bracket may include features such as a mesh venting pattern and a melting point that is lower than the temperature of battery vent byproducts that may be released during battery thermal events of the traction battery pack.

Abstract: A sun visor assembly for a vehicle that includes a mount configured to be connected to the vehicle. A guide rod having a first portion that includes a head and a second portion with a terminal end is operably coupled to the mount via the head. An impact point is at the terminal end of the second portion. The guide rod and the impact point are configured for use as a window breaker tool in a disassembled position. A visor is operably coupled to the guide rod in an assembled position and is rotatable about the guide rod from a first position to a second position. The visor includes a channel defined within the visor that is configured to receive the guide rod.

Abstract: A roof rack assembly for a vehicle includes a pedestal including an indentation. A roof rail is movable between a first configuration and a second configuration relative to the pedestal. In the first configuration, a toggle loop of the roof rail is positioned in a first orientation relative to the indentation. In the second configuration, the toggle loop is positioned in a second orientation relative to the indentation.

Abstract: A method of determining battery degradation retroactively using historical data is disclosed. The method includes the steps of collecting state of charge (SOC) and DC ampere data for a predetermined time period; determining a delta (?) SOC based on the data collected; creating a set of SOC regimes having a size based on ?SOC; filtering the SOC data and determining a set of points which indicate a charging or discharging event; and calculating overall Coulombs associated with each charging or discharging event and for each event, producing a timestamp and Coulombs associated with each event.

Abstract: A hybrid structural assembly includes a vehicle structural member extending from a first end to a second end, and a composite reinforcement member attached to the vehicle structural member between the first and second ends of the vehicle structural member. The composite reinforcement member being formed by a continuous method and cut to a predetermined length extending from the first end to the second end.

Abstract: A roof rack assembly for a vehicle includes a pedestal including an indentation. A roof rail is movable between a first configuration and a second configuration relative to the pedestal. In the first configuration, a toggle loop of the roof rail is positioned in a first orientation relative to the indentation. In the second configuration, the toggle loop is positioned in a second orientation relative to the indentation.

Abstract: A sun visor assembly for a vehicle that includes a mount configured to be connected to the vehicle. A guide rod having a first portion that includes a head and a second portion with a terminal end is operably coupled to the mount via the head. An impact point is at the terminal end of the second portion. The guide rod and the impact point are configured for use as a window breaker tool in a disassembled position. A visor is operably coupled to the guide rod in an assembled position and is rotatable about the guide rod from a first position to a second position. The visor includes a channel defined within the visor that is configured to receive the guide rod.