Patents by Inventor Steven Froelich
Steven Froelich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11421007Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.Type: GrantFiled: April 17, 2019Date of Patent: August 23, 2022Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Patent number: 11279739Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.Type: GrantFiled: April 17, 2019Date of Patent: March 22, 2022Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Publication number: 20220064237Abstract: Disclosed herein are HTT repressors and methods and compositions for use of these HTT repressors. Disclosed herein are methods and compositions for diagnosing, preventing and/or treating Huntington's Disease. In particular, provided herein are methods and compositions for modifying (e.g., modulating expression of) an HD HTT allele so as to prevent or treat Huntington Disease, including mHTT repressors (that repress mHTT transcripts and thus also repress mHTT protein expression).Type: ApplicationFiled: January 15, 2020Publication date: March 3, 2022Inventors: Galen Carey, Matthew Chiocco, Vivian Choi, Brian Felice, Steven Froelich, Debra Klatte, Jeffrey Miller, David Paschon, Edward Rebar, Bryan Zeitler, Lei Zhang, H. Steve Zhang
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Publication number: 20210369872Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.Type: ApplicationFiled: August 13, 2021Publication date: December 2, 2021Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Patent number: 11123443Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.Type: GrantFiled: August 26, 2019Date of Patent: September 21, 2021Assignee: Sangamo Therapeutics, Inc.Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Patent number: 11110154Abstract: Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.Type: GrantFiled: May 7, 2015Date of Patent: September 7, 2021Assignees: Sangamo Therapeutics, Inc., CHDI Foundation, Inc.Inventors: Steven Froelich, Seung Kwak, Ignacio Munoz-Sanjuan, H. Steve Zhang
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Publication number: 20200002390Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.Type: ApplicationFiled: August 26, 2019Publication date: January 2, 2020Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Publication number: 20190322711Abstract: The present disclosure is in the field of modulation of Htt gene expression and HTT protein levels.Type: ApplicationFiled: April 17, 2019Publication date: October 24, 2019Inventors: Steven Froelich, Ignacio Munoz-Sanjuan, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Patent number: 10435441Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.Type: GrantFiled: September 23, 2016Date of Patent: October 8, 2019Assignee: Sangamo Therapeutics, Inc.Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Patent number: 9624498Abstract: The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.Type: GrantFiled: March 18, 2015Date of Patent: April 18, 2017Assignee: SANGAMO BIOSCIENCES, INC.Inventors: Steven Froelich, Philip D. Gregory, H. Steve Zhang
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Publication number: 20170096460Abstract: Disclosed herein are Htt repressors and methods and compositions for use of these Htt repressors.Type: ApplicationFiled: September 23, 2016Publication date: April 6, 2017Inventors: Steven Froelich, Jeffrey C. Miller, David Paschon, Edward J. Rebar, Bryan Zeitler, H. Steve Zhang
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Patent number: 9561353Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.Type: GrantFiled: August 8, 2014Date of Patent: February 7, 2017Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Heejin Lee, Karen Daniel, Hong Linh Ho Duc, Michael J. Cima, Mario Castillo, Steven Froelich, Jordan Dimitrakov, Grace Y. Kim
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Publication number: 20150335708Abstract: Disclosed herein are methods and compositions for treating or preventing Huntington's Disease.Type: ApplicationFiled: May 7, 2015Publication date: November 26, 2015Inventors: Steven Froelich, Seung Kwak, Ignacio Munoz-Sanjuan, H. Steve Zhang
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Publication number: 20150267205Abstract: The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.Type: ApplicationFiled: March 18, 2015Publication date: September 24, 2015Inventors: Steven Froelich, Philip D. Gregory, H. Steve Zhang
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Publication number: 20140350473Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.Type: ApplicationFiled: August 8, 2014Publication date: November 27, 2014Inventors: Heejin Lee, Karen Daniel, Hong Linh Ho Duc, Michael J. Cima, Mario Castillo, Steven Froelich, Jordan Dimitrakov, Grace Y. Kim
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Patent number: 8801694Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.Type: GrantFiled: August 11, 2006Date of Patent: August 12, 2014Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Heejin Lee, Karen Daniel, Hong Linh Ho Duc, Michael J. Cima, Mario Castillo, Steven Froelich, Jordan Dimitrakov, Grace Y. Kim
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Patent number: 8182464Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.Type: GrantFiled: February 22, 2010Date of Patent: May 22, 2012Assignees: Massachusetts Institute of Technology, Children's Medical Center CorporationInventors: Heejin Lee, Karen Danielle Daniel, Hong Linh Ho Duc, Michael J. Cima, Mario Castillo, Steven Froelich, Jordan Dimitrakov, Grace Y. Kim
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Publication number: 20100152704Abstract: Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity.Type: ApplicationFiled: February 22, 2010Publication date: June 17, 2010Applicants: MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CHILDREN'S MEDICAL CENTER CORPORATIONInventors: Heejin Lee, Karen Daniel, Hong Linh Ho Duc, Michael J. Cima, Mario Castillo, Steven Froelich, Jordan Dimitrakov, Grace Y. Kim