Abstract: Methods, systems, and devices for generating resolution-enhanced space-domain image of a target sample based on optical coherent tomography (OCT) imaging technologies are disclosed. In an aspect, a system includes a processing platform comprising one or more processing devices operatively coupled to one or more memory devices. The processing platform is configured to acquire a plurality of related sets of optical coherence tomography (OCT) image data for a target object volume, reconstruct space-domain OCT images for each of the plurality of sets of OCT image data, coherently average the reconstructed space-domain OCT images to suppress noise or enhance a signal-to-noise ratio, and computationally expand a spatial bandwidth of the coherent-averaged OCT image data via deconvolution.

Abstract: Disclosed are devices and techniques based on optical coherence tomography (OCT) technology in combination with optical actuation. A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam into the OCT device which splits the OCT imaging beam into the optical sampling beam and the optical reference beam; and a light source that produces an optical actuation beam that is coupled along with the optical sampling beam to be directed to the sample to actuate particles or structures in the sample so that the optical imaging captures information of the sample under the optical actuation.

Abstract: Methods, systems, and devices for generating resolution-enhanced space-domain image of a target sample based on optical coherent tomography (OCT) imaging technologies are disclosed. In an aspect, a system includes a processing platform comprising one or more processing devices operatively coupled to one or more memory devices. The processing platform is configured to acquire a plurality of related sets of optical coherence tomography (OCT) image data for a target object volume, reconstruct space-domain OCT images for each of the plurality of sets of OCT image data, coherently average the reconstructed space-domain OCT images to suppress noise or enhance a signal-to-noise ratio, and computationally expand a spatial bandwidth of the coherent-averaged OCT image data via deconvolution.

Abstract: Disclosed are devices and techniques based on optical coherence tomography (OCT) technology in combination with optical actuation. A system for providing optical actuation and optical sensing can include an optical coherence tomography (OCT) device that performs optical imaging of a sample based on optical interferometry from an optical sampling beam interacting with an optical sample and an optical reference beam; an OCT light source to provide an OCT imaging beam into the OCT device which splits the OCT imaging beam into the optical sampling beam and the optical reference beam; and a light source that produces an optical actuation beam that is coupled along with the optical sampling beam to be directed to the sample to actuate particles or structures in the sample so that the optical imaging captures information of the sample under the optical actuation.

Abstract: Methods for correcting for aberrations in the image or three-dimensional reconstruction of a sampled region obtained by broadband interferometry. The sampled region is illuminated with a broadband beam of light, and light returned from the sample is detected, along with a reference beam, in order to derive an interference signal for pixels of a volume spanned by wavenumber and axes transverse to the beam propagation direction. An optimization procedure is performed with respect to a specified criterion so as to obtain an aberration-corrected image of at least one plane of the sampled region, either in a plane-specific manner or in a space-invariant manner throughout the sampled region. A filter function, which may be derived from the interference signal attendant to irradiating a sparsely distributed plurality of point scatterers, or otherwise, corrects for a detected aberrated point spread function.

Abstract: Methods for correcting for aberrations in the image or three-dimensional reconstruction of a sampled region obtained by broadband interferometry. The sampled region is illuminated with a broadband beam of light, and light returned from the sample is detected, along with a reference beam, in order to derive an interference signal for pixels of a volume spanned by wavenumber and axes transverse to the beam propagation direction. An optimization procedure is performed with respect to a specified criterion so as to obtain an aberration-corrected image of at least one plane of the sampled region, either in a plane-specific manner or in a space-invariant manner throughout the sampled region. A filter function, which may be derived from the interference signal attendant to irradiating a sparsely distributed plurality of point scatterers, or otherwise, corrects for a detected aberrated point spread function.

Abstract: A method of analyzing tissue includes inserting a radiation source into tissue, impinging radiation upon the tissue, obtaining a sample signal of the radiation that impinges upon the tissue, and determining a refractive index of the tissue from the sample signal. The method may also include determining at least one other optical property of the tissue. The method may provide for identifying tissue as part of a biopsy method. A device for analyzing tissue may include a low-coherence interferometer and a probe optically coupled to the interferometer, where the probe includes a radiation source.