Patents by Inventor Steven G. Boxer

Steven G. Boxer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120202971
    Abstract: The disclosure relates to a split GFP protein. The GFP protein includes a truncated strand and a beta strand (?-strand).
    Type: Application
    Filed: February 6, 2012
    Publication date: August 9, 2012
    Inventors: Kevin P. Kent, Steven G. Boxer, Keunbong Do
  • Publication number: 20040121377
    Abstract: Arrays of separated lipid bilayers are disclosed. Also disclosed are methods of using the arrays and methods of forming the arrrays. In addition, the invention provides useful systems and methods for selectively removing, collecting, and reconstitute lipid bilayers from specified regions of a surface. A stream of detergent solution is directed over a preformed bilayer, resulting in the removal of bilayer material. Diffusion-limited mixing between adjacent flows at low Reynolds number provides confinement of this stripping solution and, consequently, high precision. The freshly exposed surface allows formation of new connected bilayer when exposed to lipid vesicles. In conjunction with surface micropatterning and electrophoretic manipulation, the invention also provides a membrane-based separation/purification strategy.
    Type: Application
    Filed: October 6, 2003
    Publication date: June 24, 2004
    Inventors: Chiaki Ishii, Steven G. Boxer, Lance Kam
  • Patent number: 6699719
    Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Multiplexed assays using the surface detector array device of the present invention are disclosed, as are automated methods for making the surface detector array device that enable formation of arrays wherein the composition of the individual, addressable bilayer regions is unrestricted.
    Type: Grant
    Filed: July 22, 2002
    Date of Patent: March 2, 2004
    Assignee: Proteomic Systems, Inc.
    Inventors: Miki (Vikky) Yamazaki, Morrison Ulman, Luat T. Nguyen, Steven G. Boxer, John T. Groves
  • Publication number: 20040018601
    Abstract: Methods are provided for generating mobile, membrane-associated biomolecules in a supported membrane, by the process of sequestering and collecting mobile and immobile populations of biomolecules. Populations of mobile biomolecules, but not those that are immobile, can be moved to a region through a variety of mechanisms, including passive diffusion or induced drift, generating a pure, mobile population of biomolecules. In some embodiments of the invention, complex substrates are utilized, e.g. substrates containing switchable barriers to lipid diffusion, including fluidic channels; removal of regions of lipid bilayer by blotting, and the like.
    Type: Application
    Filed: February 21, 2003
    Publication date: January 29, 2004
    Inventors: Steven G. Boxer, Lance Kam
  • Publication number: 20030096418
    Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface. Multiplexed assays using the surface detector array device of the present invention are disclosed, as are automated methods for making the surface detector array device that enable formation of arrays wherein the composition of the individual, addressable bilayer regions is unrestricted.
    Type: Application
    Filed: July 22, 2002
    Publication date: May 22, 2003
    Applicant: Proteomic Systems, Inc.
    Inventors: Miki Yamazaki, Morrison Ulman, Luat T. Nguyen, Steven G. Boxer, John T. Groves
  • Publication number: 20020009807
    Abstract: The invention provides useful devices and methods for both studying interfaces between cell membranes, and integrating living cells with synthetic surfaces exhibiting complex lateral composition, organization and fluidity. Described is the fabrication of controlled interfaces between cells and synthetic supported lipid bilayer membranes.
    Type: Application
    Filed: May 17, 2001
    Publication date: January 24, 2002
    Inventors: Lance Kam, Steven G. Boxer
  • Patent number: 6228326
    Abstract: A surface detector array device suitable for use with a biosensor is disclosed. The device is formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. The bilayer-compatible surface regions carry on them, separated by a film of aqueous, supported fluid bilayers. The bilayers may contain selected receptors or biomolecules. A bulk aqueous phase covers the bilayers on the substrate surface.
    Type: Grant
    Filed: November 26, 1997
    Date of Patent: May 8, 2001
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Steven G. Boxer, Nick Ulman, Jay T. Groves