Patents by Inventor Steven G. Kelsen

Steven G. Kelsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of chronic obstructive pulmonary disease (COPD)
    Patent number: 10471086
    Abstract: The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive pulmonary disease (“COPD”) but not manifesting clinical symptoms of COPD; and 2) subjects having very severe COPD. The difference in plasma levels is statistically significant for each protein. The identification of these proteins thus facilitates susceptibility detection, early disease detection, disease severity assessment, disease progression monitoring, and therapy efficacy monitoring.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: November 12, 2019
    Assignee: Temple University—Of The Commonwealth System Of Higher Education
    Inventors: Salim Merali, Steven G. Kelsen, Carlos A. Barrero
  • Diagnosis and treatment of chronic obstructive pulmonary disease (COPD) based on elevated levels of extracellular H3 protein
    Patent number: 9933435
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Grant
    Filed: February 16, 2016
    Date of Patent: April 3, 2018
    Assignee: TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
    Publication number: 20160213700
    Abstract: The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive pulmonary disease (“COPD”) but not manifesting clinical symptoms of COPD; and 2) subjects having very severe COPD. The difference in plasma levels is statistically significant for each protein. The identification of these proteins thus facilitates susceptibility detection, early disease detection, disease severity assessment, disease progression monitoring, and therapy efficacy monitoring.
    Type: Application
    Filed: March 25, 2016
    Publication date: July 28, 2016
    Inventors: Salim Merali, Steven G. Kelsen, Carlos A. Barrero
  • Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease (COPD)
    Publication number: 20160187353
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Application
    Filed: February 16, 2016
    Publication date: June 30, 2016
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • Diagnosis and treatment of chronic obstructive pulmonary disease (COPD)
    Patent number: 9291626
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Grant
    Filed: May 11, 2012
    Date of Patent: March 22, 2016
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • DIAGNOSIS AND TREATMENT OF COPD
    Publication number: 20140294843
    Abstract: Provided is a method for diagnosing and/or staging COPD based on detection of one or more histone proteins. In some embodiments, the histone protein is an H3.3 protein comprising a post-translational modification. In some embodiments, the histone protein is H2B, H3, H3.3 or H4. Kits for practicing the methods of diagnosis and/or staging are provided as well. Further provided is a method for treating COPD.
    Type: Application
    Filed: May 11, 2012
    Publication date: October 2, 2014
    Applicant: TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Camilo Moncada, Steven G. Kelsen, Carlos A. Barrero, Oscar Mauricio Perez Leal
  • BIOMARKERS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
    Publication number: 20140030735
    Abstract: The methods described herein are based on the discovery that the plasma level of a panel of specific proteins differs between two subject populations: 1) subjects at risk for chronic obstructive pulmonary disease (“COPD”) but not manifesting clinical symptoms of COPD; and 2) subjects having very severe COPD. The difference in plasma levels is statistically significant for each protein. The identification of these proteins thus facilitates susceptibility detection, early disease detection, disease severity assessment, disease progression monitoring, and therapy efficacy monitoring.
    Type: Application
    Filed: March 7, 2012
    Publication date: January 30, 2014
    Applicant: TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Steven G. Kelsen, Carlos A. Barrero