Patents by Inventor Steven G. Reed

Steven G. Reed has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF LEISHMANIASIS
    Publication number: 20110280902
    Abstract: Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.
    Type: Application
    Filed: October 11, 2010
    Publication date: November 17, 2011
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Yasuyuki Goto, Steven G. Reed
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Patent number: 7989605
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: August 2, 2011
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik
  • Methods and Materials for the Detection of Leishmania Infection
    Publication number: 20110159528
    Abstract: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.
    Type: Application
    Filed: January 24, 2011
    Publication date: June 30, 2011
    Applicant: INBIOS INTERNATIONAL, INC.
    Inventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
  • COMPOSITIONS AND METHODS FOR THE THERAPY AND DIAGNOSIS OF BREAST CANCER
    Publication number: 20110150919
    Abstract: Compositions and methods for the therapy and diagnosis of cancer, particularly breast cancer, are disclosed. Illustrative compositions comprise one or more breast tumor polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases, particularly breast cancer.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 23, 2011
    Applicant: CORIXA CORPORATION
    Inventors: Steven G. Reed, Jiangchun Xu, Davin C. Dillon, Marc W. Retter, Susan L. Harlocker
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Patent number: 7927609
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Grant
    Filed: October 29, 2007
    Date of Patent: April 19, 2011
    Assignee: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
    Publication number: 20110070290
    Abstract: Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
    Type: Application
    Filed: July 26, 2010
    Publication date: March 24, 2011
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Steven G. Reed, Darrick Carter
  • VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
    Publication number: 20110014274
    Abstract: Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
    Type: Application
    Filed: July 26, 2010
    Publication date: January 20, 2011
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Steven G. Reed, Darrick Carter
  • SYNTHETIC GLUCOPYRANOSYL LIPID ADJUVANTS
    Publication number: 20100310602
    Abstract: Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.
    Type: Application
    Filed: June 4, 2010
    Publication date: December 9, 2010
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Steven G. Reed, Darrick Carter
  • Compounds and methods for diagnosis and treatment of leishmaniasis
    Patent number: 7833534
    Abstract: Compounds and methods are provided for diagnosing, preventing, treating and detecting leishmaniasis infection and stimulating immune responses in patients are disclosed. The compounds disclosed are include polypeptides and fusion proteins that contain at least one immunogenic portion of one or more Leishmania antigens, or a variant thereof. Additionally, methods of screening a screening library for tandem repeat proteins that have immunogenic properties are disclosed. Vaccines and pharmaceutical compositions comprising polynucleotides, polypeptides, fusion proteins and variants thereof that may be used for the prevention and therapy of leishmaniasis, as well as for the detection of Leishmaniasis infection are described.
    Type: Grant
    Filed: April 10, 2007
    Date of Patent: November 16, 2010
    Assignee: Infectious Disease Research Institute
    Inventors: Yasuyuki Goto, Steven G. Reed
  • RECOMBINANT POLYPROTEIN VACCINES FOR THE TREATMENT AND DIAGNOSIS OF LEISHMANIASIS
    Publication number: 20100136046
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or variants thereof, as well as polynucleotides encoding such fusion polypeptides.
    Type: Application
    Filed: November 18, 2009
    Publication date: June 3, 2010
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Yasuyuki Goto, Steven G. Reed
  • IMMUNOGENIC COMPOSITIONS COMPRISING MYCOBACTERIUM TUBERCULOSIS POLYPEPTIDES AND FUSIONS THEREOF
    Publication number: 20100129391
    Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infection.
    Type: Application
    Filed: April 4, 2008
    Publication date: May 27, 2010
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Steven G. Reed, Rhea N. Coler, Gregory C. Ireton
  • Compositions and methods for the detection of infection
    Patent number: 7695925
    Abstract: Compositions comprising fusion polypeptides of T. cruzi epitopes are provided, together with methods for the use of such compositions in the diagnosis of T. cruzi infection and in screening blood supplies. Diagnostic kits comprising such compositions are also provided.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: April 13, 2010
    Assignees: Inbios International, Inc., Infectious Disease Research Institute
    Inventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
  • FUSION PROTEINS AND THEIR USE IN THE DIAGNOSIS AND TREATMENT OF LEISHMANIASIS
    Publication number: 20100008924
    Abstract: The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particularly visceral leishmaniasis in animals such as humans and dogs.
    Type: Application
    Filed: July 2, 2009
    Publication date: January 14, 2010
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Ajay Bhatia, Steven G. Reed
  • COMPOUNDS AND METHODS FOR DIAGNOSIS AND TREATMENT OF CHAGAS DISEASE
    Publication number: 20090325204
    Abstract: Compounds and methods are provided herein that provide for diagnosis and treatment of Chagas disease.
    Type: Application
    Filed: June 29, 2009
    Publication date: December 31, 2009
    Inventors: Steven G. Reed, Yasuyuki Goto
  • Methods and Materials for the Detection of Leishmania Infection
    Publication number: 20090317841
    Abstract: The present invention provides rapid diagnostic assays for the detection of Leishmania which can readily be used in the field, leading to more rapid treatment. In certain embodiments, the inventive assays, including ELISA and lateral flow assays, employ antibodies that may be effectively employed to detect the Leishmania major antigen TSA, which is present in both promastigotes grown in culture and in amastigotes. Such assays may be employed to detect the presence of cutaneous leishmaniasis in a subject using scrapings, biopsies, and/or aspirates taken from cutaneous lesions.
    Type: Application
    Filed: December 6, 2006
    Publication date: December 24, 2009
    Inventors: Raymond L. Houghton, Steven G. Reed, Syamal Raychaudhuri
  • COMPOUNDS AND METHODS FOR IMMUNOTHERAPY AND DIAGNOSIS OF TUBERCULOSIS
    Publication number: 20090312244
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Application
    Filed: October 29, 2007
    Publication date: December 17, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A.W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel R. Twardzik, Michael J. Lodes, Ronald C. Hendrickson
  • RECOMBINANT POLYPROTEIN VACCINES FOR THE TREATMENT AND DIAGNOSIS OF LEISHMANIASIS
    Publication number: 20090291099
    Abstract: Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise fusion polypeptides comprising multiple Leishmania antigens, in particular, KMP11, SMT, A2 and/or CBP, or immunogenic portions or variants thereof, as well as polynucleotides encoding such fusion polypeptides.
    Type: Application
    Filed: May 15, 2009
    Publication date: November 26, 2009
    Applicant: INFECTIOUS DISEASE RESEARCH INSTITUTE
    Inventors: Yasuyuki Goto, Steven G. Reed
  • Fusion proteins of mycobacterium tuberculosis antigens and their uses
    Publication number: 20090281168
    Abstract: The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
    Type: Application
    Filed: October 29, 2007
    Publication date: November 12, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. Skeiky, Davin C. Dillon, Mark Alderson, Antonio Campos-Nero
  • VACCINE COMPOSITION CONTAINING SYNTHETIC ADJUVANT
    Publication number: 20090181078
    Abstract: Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
    Type: Application
    Filed: January 9, 2009
    Publication date: July 16, 2009
    Applicant: Infectious Disease Research Institute
    Inventors: Steven G. Reed, Darrick Carter
  • Compounds and methods for immunotherapy and diagnosis of tuberculosis
    Publication number: 20090017077
    Abstract: Compounds and methods for inducing protective immunity against tuberculosis are disclosed. The compounds provided include polypeptides that contain at least one immunogenic portion of one or more M. tuberculosis proteins and DNA molecules encoding such polypeptides. Such compounds may be formulated into vaccines and/or pharmaceutical compositions for immunization against M. tuberculosis infection, or may be used for the diagnosis of tuberculosis.
    Type: Application
    Filed: October 29, 2007
    Publication date: January 15, 2009
    Applicant: Corixa Corporation
    Inventors: Steven G. Reed, Yasir A. W. Skeiky, Davin C. Dillon, Antonio Campos-Neto, Raymond Houghton, Thomas S. Vedvick, Daniel T. Twardzik