Abstract: A thermal insulation and fire protection felt product is provided. The felt product includes a first layer including a first plurality of nonwoven mechanically entangled oxidized polyacrylonitrile (PAN) precursor fibers bonded together by a first plurality of melted thermoplastic polyphenylene sulfide (PPS) fibers homogeneously mixed with the first plurality of mechanically entangled PAN precursor fibers. The first plurality of melted thermoplastic PPS fibers form a matrix of bond points between individual fibers of the first plurality of mechanically entangled PAN fibers. A second layer includes a second plurality of nonwoven mechanically entangled oxidized PAN precursor fibers bonded together by a second plurality of melted thermoplastic PPS fibers homogeneously mixed with the second plurality of mechanically entangled PAN precursor fibers.

Abstract: This document discusses, among other things, a valve assembly for controlling an exhaust pressure of a gas combustion system. The valve assembly can include a valve housing, a flapper, and a biasing device. The valve housing can be coupleable to an exhaust pipe. The flapper can be pivotably couplable to the valve housing to pivot between a full open position and a restricted position in response to exhaust pressure. The biasing device can be couplable to the housing and extendable into the exhaust pipe to engage the flapper, where the biasing device can be configured to bias the flapper toward the restricted position and can be configured to resist movement of the flapper between the restricted position and the full open position.

Abstract: Systems and methods are disclosed for conversationally-relevant content requests. In one implementation, a first communication is processed to identify a first content element within the communication. The first content element is stored within a first content repository. A content request is generated based on the first content repository. The content request is provided to the user. A second communication is received from the user in response to the content request. An action is initiated based on the second communication.

Abstract: This document discusses, among other things, a valve assembly for controlling an exhaust pressure of a gas combustion system. The valve assembly can include a valve housing, a flapper, and a biasing device. The valve housing can be coupleable to an exhaust pipe. The flapper can be pivotably couplable to the valve housing to pivot between a full open position and a restricted position in response to exhaust pressure. The biasing device can be couplable to the housing and extendable into the exhaust pipe to engage the flapper, where the biasing device can be configured to bias the flapper toward the restricted position and can be configured to resist movement of the flapper between the restricted position and the full open position.

Abstract: Systems and methods are disclosed for conversationally-relevant content requests. In one implementation, a first communication is processed to identify a first content element within the communication. The first content element is stored within a first content repository. A content request is generated based on the first content repository. The content request is provided to the user. A second communication is received from the user in response to the content request. An action is initiated based on the second communication.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.

Abstract: A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.

Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.

Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Abstract: When a programmer creates an object for use in a display screen of a human-machine interface device of a programmable system, at least some of the properties of the object are associated with a variable quantity. The programmer determines the property or properties for which the corresponding variable quantity is reassignable and which are fixed, by carrying out a setting operation, and creating an association record identifying which property or properties have a reassignable variable quantity. The object may then be stored in a library and transferred to the memory of the human-machine interface device. If a subsequent programmer wants to re-use the object by reassigning the variable quantity of one or more of the properties of the object, the association record is used to determine the property or properties for which the corresponding variable quantity is reassignable.

Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.

Abstract: Automated System for Commissioning Verification, Progress Tracking and Punchlist Resolution of Oil and Gas Production Facilities is disclosed. This invention eliminates the need for manual generation of hardcopy inspection reports and engineering documents by providing field inspectors mobile devices for real-time access to the document control system. The invention also provides immediate notification to all Users when a revised document has been uploaded into the document control system. The invention provides automated and real-time progress updates, and eliminates delays from manually coding and scanning documents. Punchlist deficiencies and corresponding digital images are entered in the field for immediate viewing by onsite and offsite management, engineers and vendors via internet access, allowing for immediate direction or approvals. Material procurement requirements are entered in the field for immediate viewing and action by procurement personnel.

Abstract: A clear, frosted, or colored, transparent and/or translucent, plastic, or composite skateboard, snowboard, or any sports board material, that is illuminated with replaceable, rechargeable, or self-charging battery powered light emitting diodes which are placed inside the board within an inexpensive, drop-in, modular housing, which serves as a light engine and provides light that is transmitted through the interior of the board itself in order to illuminate light altering elements which are embedded inside the board and/or etched, printed or applied to the surface of the board. This glowing light creates unique artistic light patterns, flashing sequences, and glowing designs throughout the interior and exterior of the board.

Abstract: A magnetic recording disk with pre-patterned surface features of elevated lands and recessed grooves or trenches, like a discrete-track media (DTM) or bit-patterned media (BPM) disk, has a planarized surface. A multilayered disk overcoat is used to protect the recording layer, and at least one of the overcoat layers functions as a stop layer for terminating a chemical-mechanical polishing (CMP) process that substantially planarizes the disk. All of the layers of the multilayered overcoat are located above the lands, but none of the overcoat layers, or a number of layers less than the number of layers over the lands, is located above the recesses.

Abstract: A magnetic recording disk with pre-patterned surface features of elevated lands and recessed grooves or trenches, like a discrete-track media (DTM) or bit-patterned media (BPM) disk, has a planarized surface. A multilayered disk overcoat is used to protect the recording layer, and at least one of the overcoat layers functions as a stop layer for terminating a chemical-mechanical polishing (CMP) process that substantially planarizes the disk. All of the layers of the multilayered overcoat are located above the lands, but none of the overcoat layers, or a number of layers less than the number of layers over the lands, is located above the recesses.

Abstract: 14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may be found by screening, selected from known strains (e.g. Streptomyces eurythermus DSM 40014) or produced by genetically engineering a strain to express a cytochrome P450 enzyme.

Abstract: A system and related techniques manage the adding of digital images or other media to email messages using a comparatively straightforward insert-and-send scheme. A user may choose to insert or embed comparatively low-resolution versions of images or other media automatically published to a media server into an email message. The recipient of that media-enabled message may receive and view the email text message along with the low-resolution images in typical fashion using an email or other client. The recipient may choose to view one or more of the embedded images in greater resolution by linking or activating those images, for instance by moving a cursor and clicking into the selected image or other object. Activating the image or other media object from within the email pane may seamlessly transport the user to the media server's Web page to view a larger-resolution version of that image, for instance using a media player. Video, audio and other media may likewise be inserted into messages.

Abstract: Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.

Abstract: A method for Internet protocol (IP) address discovery in a rapidly changing network environment is presented. A server and a client use an adaptive discovery polling process to determine an optimum heartbeat interval that minimizes network traffic and allows the server to monitor the client's source address. The client and server exchange discovery poll messages and heartbeat messages at varying time intervals in order to identify a computer network's timeout period or a network address translator's message block timeout period. Once the timeout period is identified, the client sends heartbeat messages to the server at an “optimum heartbeat interval” that is less than the identified timeout period in order to maintain the network connection. As a result, the server is able to send messages to the client without delay.