Patents by Inventor Steven Gary Kendrew

Steven Gary Kendrew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for increasing molecular diversity of polyketides and non-ribosomal proteins
    Patent number: 9976165
    Abstract: A method for increasing the molecular diversity of polyketides and non-ribosomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding the polyketide or peptide.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: May 22, 2018
    Assignee: ISOMERASE THERAPEUTICS, LTD.
    Inventors: Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wilkinson
  • METHODS FOR INCREASING MOLECULAR DIVERSITY OF POLYKETIDES AND NON-RIBOSOMAL PROTEINS
    Publication number: 20170101659
    Abstract: A method for increasing the molecular diversity of polyketides and non-ribsomomal peptides by using recombination to efficiently increase or decrease the number of modules in the polyketide synthase or non-ribosomal peptide synthetase encoding said polyketide or peptide.
    Type: Application
    Filed: July 9, 2014
    Publication date: April 13, 2017
    Applicant: ISOMERASE THERAPEUTICS LTD.
    Inventors: Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wikinson
  • Rapamycin analogues and their pharmaceutical use
    Patent number: 9505773
    Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: November 29, 2016
    Assignee: Isomerase Therapeutics Ltd.
    Inventors: Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wilkinson
  • RAPAMYCIN ANALOGUES AND THEIR PHARMACEUTICAL USE
    Publication number: 20160176893
    Abstract: Novel rapamycin analogues and methods for their production with FKBP and/or MIP inhibitory activity with reduced mTOR inhibitory activity with therapeutic potential e.g. as bacterial virulence inhibitors.
    Type: Application
    Filed: July 9, 2014
    Publication date: June 23, 2016
    Inventors: Matthew Alan Gregory, Steven Gary Kendrew, Steven James Moss, Barrie Wilkinson
  • Sanglifehrin derivatives and methods for their production
    Patent number: 9271977
    Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: March 1, 2016
    Assignee: NeuroVive Pharmaceutical AB
    Inventors: Steven James Moss, Matthew Alan Gregory, Barrie Wilkinson, Steven Gary Kendrew, Christine Janet Martin
  • Sanglifehrin Derivatives and Methods for Their Production
    Publication number: 20140080837
    Abstract: There are provided inter alia compounds of formula (I) and (II) and their use in therapy, particularly for the treatment of viral infection.
    Type: Application
    Filed: December 20, 2011
    Publication date: March 20, 2014
    Applicant: Neurovive Pharmaceuticals AB
    Inventors: Steven James Moss, Matthew Alan Gregory, Barrie Wilkinson, Steven Gary Kendrew, Christine Janet Martin
  • Erythromycins and process for their preparation
    Patent number: 7807800
    Abstract: 14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may be found by screening, selected from known strains (e.g. Streptomyces eurythermus DSM 40014) or produced by genetically engineering a strain to express a cytochrome P450 enzyme.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: October 5, 2010
    Assignee: Biotica Technology Limited
    Inventors: Steven Gary Kendrew, Rachel E. Lill
  • Polyketides and their synthesis
    Patent number: 7595175
    Abstract: Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.
    Type: Grant
    Filed: August 14, 2001
    Date of Patent: September 29, 2009
    Assignee: Biotica Technology Limited
    Inventors: Hrvoje Petkovic, Steven Gary Kendrew, Peter Francis Leadlay
  • Polyketides and their synthesis
    Publication number: 20040023342
    Abstract: Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within the acyltransferase (AT) domains of the PKSs. Particular motifs in or near the substrate binding pocket are disclosed, such that alterations therein affect substrate specificity.
    Type: Application
    Filed: July 31, 2003
    Publication date: February 5, 2004
    Inventors: Hrvoje Petkovic, Steven Gary Kendrew, Peter Francis Leadlay