Abstract: A particulate delivery and packing apparatus for depositing and compressing particulate material in elongate containers. The containers may have one closed end or two open ends. A modular elongate container magazine is positioned on a base plate of the apparatus to receive a controlled-descent hopper having a plurality of packing tubes extending downwardly from a bottom end of the hopper. Each of the plurality of packing tubes is aligned with a channel in the container magazine and is incrementally lowered into the channel to deposit particulate material. The leading edge of the packing tube compresses the deposited material via an oscillation movement and is incrementally withdrawn to deposit additional particulate material. A vibration-emitting electromagnet/magnetic conductor combination imparts vibration energy to the packing tubes to perform the packing/compression function.

Abstract: A modified bullet cartridge having a score line formed around a primer bore. The score line may be positioned symmetrically or asymmetrically about the primer bore. The score line may have a regular or irregular two-dimensional geometric shape. A modified bullet cartridge having a counter-bore formed superposed about a primer bore. The counter-bore may have a vertical counter-bore extension and/or a radial counter-bore extension. Adhesive is positioned in the counter-bore about a primer secured in the primer bore. The primer may have a radial flange extending radially from an exterior sidewall of the primer. The flange registers against a bottom surface of the counterbore, or within a radial flange extension if present. Adhesive is used to lock the primer flange against the counter-bore and/or radial counter-bore extension. The combination of the counter-bore, adhesive and optionally the flanged primer locks the primer to the bullet cartridge to render the cartridge unusable after one use.

Abstract: A modified bullet cartridge having a score line formed around a primer bore. The score line may be positioned symmetrically or asymmetrically about the primer bore. The score line may have a regular or irregular two-dimensional geometric shape. A modified bullet cartridge having a counter-bore formed superposed about a primer bore. The counter-bore may have a vertical counter-bore extension and/or a radial counter-bore extension. Adhesive is positioned in the counter-bore about a primer secured in the primer bore. The primer may have a radial flange extending radially from an exterior sidewall of the primer. The flange registers against a bottom surface of the counterbore, or within a radial flange extension if present. Adhesive is used to lock the primer flange against the counter-bore and/or radial counter-bore extension. The combination of the counter-bore, adhesive and optionally the flanged primer locks the primer to the bullet cartridge to render the cartridge unusable after one use.

Abstract: In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid sequences comprising heavy and light chain immunoglobulin molecules, particularly contiguous heavy and light chain sequences spanning the complementarity determining regions (CDRs), specifically from within FR1 and/or CDR1 through CDR3 and/or within FR4, are provided. Further provided are antibodies having similar binding properties and antibodies (or other antagonists) having similar functionality as antibodies disclosed herein.