Patents by Inventor Steven Goldman

Steven Goldman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12178834
    Abstract: The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
    Type: Grant
    Filed: May 9, 2022
    Date of Patent: December 31, 2024
    Assignee: University of Rochester
    Inventors: Steven Goldman, Fraser J. Sim
  • Patent number: 11980698
    Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: May 14, 2024
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jordan J. Lancaster, Steven Goldman
  • Publication number: 20240131225
    Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, including a dual fiber scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.
    Type: Application
    Filed: December 13, 2023
    Publication date: April 25, 2024
    Inventors: Jordan J. Lancaster, Steven Goldman, Jennifer Watson Koevary
  • Patent number: 11890395
    Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.
    Type: Grant
    Filed: June 15, 2018
    Date of Patent: February 6, 2024
    Assignee: AVERY THERAPEUTICS, INC.
    Inventors: Jordan J. Lancaster, Steven Goldman, Jennifer Watson Koevary
  • Patent number: 11826491
    Abstract: The present invention provides compositions and methods for improving cardiac function. Specifically, the present invention provides compositions and methods for treating a subject having a disorder or condition associated with aberrant cardiac tissue function, comprising contacting a patient having a disorder or condition associated with aberrant cardiac tissue function with a construct, or a construct associated with therapeutic cells, or a construct associated with fibroblast cells and therapeutic cells.
    Type: Grant
    Filed: July 7, 2018
    Date of Patent: November 28, 2023
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Jordan J. Lancaster, Steven Goldman, Jennifer W. Koevary, Ikeotunye R. Chinyere
  • Publication number: 20220273728
    Abstract: The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
    Type: Application
    Filed: May 9, 2022
    Publication date: September 1, 2022
    Inventors: Steven GOLDMAN, Fraser J. SIM
  • Patent number: 11344582
    Abstract: The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: May 31, 2022
    Assignee: UNIVERSITY OF ROCHESTER
    Inventors: Steven Goldman, Fraser J. Sim
  • Publication number: 20210393853
    Abstract: Systems, methods, and compositions for cryopreservation and reconstitution of engineered tissues. The engineered tissue compositions are functional after a cryopreservation-thaw cycle For example, the tissue compositions retain their structural integrity, maintain cell-cell communication, etc. In certain embodiments, the tissue compositions exhibit synchronous contractions, secrete a hormone, secrete a cytokine, secrete an RNA, secrete a growth factor, secrete an enzyme, and/or secrete a neurotransmitter, etc. in some embodiments, engineered tissue compositions are cultured, cryopreserved, and reconstituted in a closed system.
    Type: Application
    Filed: October 29, 2019
    Publication date: December 23, 2021
    Inventors: Jordan J. Lancaster, Jennifer Watson Koevary, Steven Goldman
  • Publication number: 20210386827
    Abstract: Cell-free compositions for promoting restoration of tissue function or enhancement of tissue function and methods of stimulating or promoting restoration or enhancement of tissue function using the cell-free compositions. The compositions herein help stimulate endogenous pathways via a subject's own cells effectively for improving tissue function, enhancing tissue function, enhancing cell proliferation, etc. The compositions comprise one or a plurality of therapeutic components such as growth factors, extracellular matrix, DNA, RNA, hormones, drugs, cell surface receptors, enzymes, cytokines, angiogenesis modulating factors, etc., e.g., any material that can effectively activation endogenous pathways in the subject's own cell to a desired effect. The cell-free composition comprises a carrier or is attached to or integrated into and/or within a carrier.
    Type: Application
    Filed: October 15, 2019
    Publication date: December 16, 2021
    Inventors: Jennifer Watson Koevary, Jordan J. Lancaster, Steven Goldman
  • Publication number: 20210290823
    Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.
    Type: Application
    Filed: June 1, 2021
    Publication date: September 23, 2021
    Inventors: Jordan J. Lancaster, Steven Goldman
  • Publication number: 20210215674
    Abstract: Provided herein are compositions and methods for screening compounds for cardiac effects (e.g., positive and negative effects). In particular, provided herein are engineered cardiac tissues suitable for measuring the effect of compounds on specific properties (e.g., electrical properties) of such engineered cardiac tissues.
    Type: Application
    Filed: May 17, 2019
    Publication date: July 15, 2021
    Inventors: Ikeotunye R. Chinyere, Jordan J. Lancaster, Jennifer W. Koevary, Steven Goldman
  • Patent number: 11020510
    Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: June 1, 2021
    Assignees: Arizona Board of Regents on Behalf of the University of Arizona, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jordan J. Lancaster, Steven Goldman
  • Patent number: 10856938
    Abstract: Systems are provided for assessing the likelihood that a sample of cardiac tissue will spontaneously exhibit disordered electrical activity. These systems induce ventricular tachycardia or other disordered electrical activity in a sample of human and/or animal cardiac tissue either in vivo or in vitro. This system can be used to assess the ability of various pharmaceuticals, genetic modifications, electrical pacing, surgical ablation, or other therapeutic interventions to prevent or halt such disordered electrical activity. This system detects electrical activity from a plurality of points on the surface of the sample of cardiac tissue and generates one or more maps of monophasic action potential amplitude, monophasic action potential duration, local field amplitude, or other electrophysiological parameters of the cardiac tissue.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: December 8, 2020
    Assignee: THE ARIZONA BOARD OF REGENTS ON BEHAFT OF THE UNIVERSITY OF ARIZONA
    Inventors: Ikeotunye Royal Chinyere, Jen Watson Koevary, Jordan Lancaster, Steven Goldman, Russell Witte, Kyle Weigand
  • Publication number: 20200330646
    Abstract: Provided herein are scaffolds (e.g., synthetic meshes) having optimized material properties (e.g., initial stiffness, tensile strength) and related uses thereof (e.g., use in cardiac medical procedures).
    Type: Application
    Filed: November 16, 2018
    Publication date: October 22, 2020
    Inventors: Steven Goldman, Jordan Lancaster, Jennifer Koevary
  • Publication number: 20200171206
    Abstract: The present invention provides compositions and methods for improving cardiac function. Specifically, the present invention provides compositions and methods for treating a subject having a disorder or condition associated with aberrant cardiac tissue function, comprising contacting a patient having a disorder or condition associated with aberrant cardiac tissue function with a construct, or a construct associated with therapeutic cells, or a construct associated with fibroblast cells and therapeutic cells.
    Type: Application
    Filed: July 7, 2018
    Publication date: June 4, 2020
    Inventors: Jordan J. LANCASTER, Steven GOLDMAN, Jennifer W. KOEVARY, Ikeotunye R. CHINYERE
  • Publication number: 20190142999
    Abstract: Disclosed herein are contractile cell constructs, methods for using them to treat disease, and methods for making them.
    Type: Application
    Filed: December 20, 2018
    Publication date: May 16, 2019
    Inventors: Jordan J. Lancaster, Steven Goldman
  • Publication number: 20190008584
    Abstract: Systems are provided for assessing the likelihood that a sample of cardiac tissue will spontaneously exhibit disordered electrical activity. These systems induce ventricular tachycardia or other disordered electrical activity in a sample of human and/or animal cardiac tissue either in vivo or in vitro. This system can be used to assess the ability of various pharmaceuticals, genetic modifications, electrical pacing, surgical ablation, or other therapeutic interventions to prevent or halt such disordered electrical activity. This system detects electrical activity from a plurality of points on the surface of the sample of cardiac tissue and generates one or more maps of monophasic action potential amplitude, monophasic action potential duration, local field amplitude, or other electrophysiological parameters of the cardiac tissue.
    Type: Application
    Filed: July 5, 2018
    Publication date: January 10, 2019
    Applicant: THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV ERSITY OF ARIZONA
    Inventors: Ikeotunye Royal Chinyere, Jen Watson Koevary, Jordan Lancaster, Steven Goldman, Russell Witte, Kyle Weigand
  • Patent number: 10172976
    Abstract: Disclosed herein are contractile cell constructs comprising contractile cells, or progenitors thereof, adhered to a surface of a three dimensional fibroblast containing scaffold (3DFCS) and methods for using them to treat disease. In one aspect, the present invention provides methods for preparing a contractile construct, comprising (a) seeding immature contractile cells onto the surface of a three dimensional fibroblast containing scaffold (3DFCS) to produce a contractile construct; and (b) culturing the contractile construct under conditions to promote differentiation of the immature contractile cells into mature contractile cells, wherein the mature contractile cells form striations.
    Type: Grant
    Filed: October 8, 2014
    Date of Patent: January 8, 2019
    Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Jordan J. Lancaster, Steven Goldman
  • Publication number: 20180361025
    Abstract: Engineered tissue compositions for supporting cell growth, maintenance, and/or differentiation featuring a scaffold, extracellular matrix (ECM) material, and optionally a population of ECM-generating cells such as fibroblasts. The tissue compositions may be used for supporting seeded cells of a particular cell type of interest such as cells related to skeletal muscle, smooth muscle, cardiac tissue, gastrointestinal tissue, etc. The tissue compositions with seeded cells may develop into functional tissues, which may have the potential to provide a tissue graft for therapeutic purposes or a valuable model for in vitro assays.
    Type: Application
    Filed: June 15, 2018
    Publication date: December 20, 2018
    Inventors: Jordan J. Lancaster, Steven Goldman, Jennifer Watson Koevary
  • Publication number: 20170209494
    Abstract: The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
    Type: Application
    Filed: February 10, 2017
    Publication date: July 27, 2017
    Applicant: University of Rochester
    Inventors: Steven GOLDMAN, Fraser J. SIM