Abstract: The present invention relates to a polypeptide in which: (i) the N-terminal sequence includes the polypeptide sequence of the GBSSI (Granule Bound Starch Synthase I) or a derivative or fragment thereof, wherein said polypeptide sequence can bind to starch; and (ii) the C-terminal sequence includes a polypeptide sequence coding for at least one epitope of an antigen from a parasite of the Plasmodium type; the invention also relates to a polynucleotide coding for such polypeptide, a vector containing said polynucleotide, a cell transformed by such vector, a transformed organism including such transformed cell, a pharmaceutical composition containing such polypeptide, and the use of such polypeptide in the preparation of a drug for the prophylactic treatment of a subject suffering from a pathology associated with a Plasmodium-type parasite, preferably malaria.