Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

Abstract: A gutter cover for a rain gutter includes a U-shaped rear portion, a forward edge portion, and a perforated horizontal central portion spanning between the rear and forward edge portions. The forward edge portion includes a web extending upwardly from the central portion, and a covering flange and downward hooked edge portion extending forwardly from the web. The hooked edge portion having an end positioned for engagement with the underside of a front lip of the gutter.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: Novel methods and apparatus for sorting and enriching target cells of interest from a mixture.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: A gutter cover for a rain gutter includes a U-shaped rear portion, a forward edge portion, and a perforated horizontal central portion spanning between the rear and forward edge portions. The forward edge portion includes a web extending upwardly from the central portion, and a covering flange and downward hooked edge portion extending forwardly from the web. The hooked edge portion having an end positioned for engagement with the underside of a front lip of the gutter.

Abstract: A gutter cover for a rain gutter includes a U-shaped rear portion, a forward edge portion, and a perforated horizontal central portion spanning between the rear and forward edge portions. The forward edge portion includes a web extending upwardly from the central portion, and a covering flange and downward hooked edge portion extending forwardly from the web. The hooked edge portion having an end positioned for engagement with the underside of a front lip of the gutter.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: A lighting system for temporal, irradiance-controlled photoacclimation includes a photoacclimation controller configured to generate control signals based on a photoacclimation schedule, a user interface configured to receive user input to the photoacclimation controller, the photoacclimation schedule based on the user input, a plurality of luminaires configured to emit light suitable for photosynthesis in plants at a plurality of different selectable levels of light output, and a communications network via which the control signals are provided to the plurality of luminaires, the luminaires adjusting the light output in response to the control signals.

Abstract: A gutter cover for a rain gutter includes a U-shaped rear portion, a forward edge portion, and a perforated horizontal central portion spanning between the rear and forward edge portions. The forward edge portion includes a web extending upwardly from the central portion, and a covering flange and downward hooked edge portion extending forwardly from the web. The hooked edge portion having an end positioned for engagement with the underside of a front lip of the gutter.

Abstract: The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Abstract: The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Abstract: The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Abstract: The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Abstract: The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.

Abstract: The present invention includes an apparatus and corresponding method for concentrating analytes within a fluid flowing through a tube using acoustic radiation pressure. The apparatus includes a function generator that outputs a radio frequency electrical signal to a transducer that transforms the radio frequency electric signal to an acoustic signal and couples the acoustic signal to the tube. The acoustic signal is converted within the tube to acoustic pressure that concentrates the analytes within the fluid.