Patents by Inventor Steven GREENWAY

Steven GREENWAY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AORTA-SPECIFIC DNA METHYLATION PATTERNS IN CELL-FREE DNA FROM PATIENTS WITH BICUSPID AORTIC VALVE-ASSOCIATED AORTOPATHY
    Publication number: 20230265493
    Abstract: Described herein is a method of determining the risk of a human subject with congenital BAV having BAV-associated aortopathy or developing BAV-associated aortopathy, comprising: obtaining a cell free DNA (cfDNA) sample from the subject, measuring the level of methylation of a methylation marker that is associated with BAV-associated aortopathy in the cfDNA sample, optionally comparing the level of methylation of the methylation maker in the sample of the subject with a comparator control, wherein when the methylation marker is hypo- or hypermethylated the subject as being at risk of developing BAV-associated aortopathy.
    Type: Application
    Filed: December 16, 2022
    Publication date: August 24, 2023
    Inventors: Steven GREENWAY, Paul W.M. FEDAK, Ashna Karimbhai MAREDIA, Mohammad ALEINATI
  • Plasma derived cell-free mitochondrial deoxyribonucleic acid
    Patent number: 11104954
    Abstract: The present disclosure relates to a method for isolating and amplifying a subject's mitochondrial deoxyribonucleic acid (mtDNA). The method comprises the steps of: isolating cell free deoxyribonucleic acid (cf-DNA) from a plasma sample obtained from the subject; and amplifying the mtDNA within the isolated cfDNA using a polymerase chain reaction with a first primer pair and a second primer pair. The first primer is selected from SEQ ID NO: 1 and SEQ ID NO: 2 and the second primer pair is selected from SEQ ID NO: 3 and SEQ ID NO: 4.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: August 31, 2021
    Assignees: M.A.G.I.C. Clinic Ltd., The Governors of the University of Alberta
    Inventors: Aneal Khan, Christopher Newell, Stacey Hume, Steven Greenway
  • PLASMA DERIVED CELL-FREE MITOCHONDRIAL DEOXYRIBONUCLEIC ACID
    Publication number: 20190112661
    Abstract: The present disclosure relates to a method for isolating and amplifying a subject's mitochondrial deoxyribonucleic acid (mtDNA). The method comprises the steps of: isolating cell free deoxyribonucleic acid (cf-DNA) from a plasma sample obtained from the subject; and amplifying the mtDNA within the isolated cfDNA using a polymerase chain reaction with a first primer pair and a second primer pair. The first primer is selected from SEQ ID NO: 1 and SEQ ID NO: 2 and the second primer pair is selected from SEQ ID NO: 3 and SEQ ID NO: 4.
    Type: Application
    Filed: March 31, 2017
    Publication date: April 18, 2019
    Inventors: Aneal KHAN, Christopher NEWELL, Stacey HUME, Steven GREENWAY