Abstract: The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The present invention relates to a novel compound having a function of inhibiting ROR? activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I or II, or the pharmaceutically acceptable salts thereof, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: A method and lifting arrangement for lowering and raising a single rotor blade of a wind turbine from a six-o'clock position is provided. Lifting fixtures are symmetrically installed on a hub surface about the rotor blade being replaced. Lifting lines from coordinated ground winches pass over the lifting fixtures to support the blade and attach to a blade harness. The blade harness attaches over a substantial length of the rotor blade, distributing the blade weight broadly. A tail pick crane facilitates transfer of the rotor blade between a vertical and a horizontal position stored position.

Abstract: Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof: are selective inhibitors of the 11?-HSD1 enzyme. They inhibit the 11?-HSD1-mediated conversion of cortisone and other 11-keto-glucocorticoids to cortisol and other 11?-hydroxy-glucocorticoids. The 11?-HSD1 inhibitors therefore decrease the amount of cortisol in target tissues, thereby modulating the effects of cortisol.

Abstract: Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11?-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidernia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.

Abstract: Coumermycin analogs of general formula I: wherein X, a linking group, is selected from the group consisting of alkyl, aryl, diaryl, substituted alkyl, substituted aryl, alkyl with hereroatoms in the chain, heteroaryl, cyclic and bicyclic alkyl, and a combination of alkyl, aryl and heteroaryl substituents. The compounds are suitable for use as chemical dimerizers of chimeric proteins.

Abstract: Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: 1

Abstract: Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: are selective inhibitors of the 11&bgr;-HSD1 enzyme. The compounds are useful for the treatment of diabetes, such as noninsulin-dependent diabetes (NIDDM), hyperglycemia, obesity, insulin resistance, dylsipidemia, hyperlipidemia, hypertension, Syndrome X, and other symptoms associated with NIDDM.

Abstract: Compounds having Formula I, including pharmaceutically acceptable salts, hydrates and solvates thereof: 1

Abstract: This invention relates to novel substituted succinic acid metallo-&bgr;-lactamase inhibitors which are useful potentiators of &bgr;-lactam antibiotics.

Abstract: This invention relates to novel substituted succinic acid metallo-&bgr;-lactamase inhibitors which are useful potentiators of &bgr;-lactam antibiotics. Accordingly, the present invention provides a method of treating bacterial infections in animals or humans which comprises administering, together with a b-lactam antibiotic, a therapeutically effective amount of a compound of formula I: including pharmaceutically acceptable salts, prodrugs, anhydrides, and solvates thereof.

Abstract: This invention relates to novel substituted succinic acid metallo-&bgr;-lactamase inhibitors which are useful potentiators of &bgr;-lactam antibiotics.

Abstract: Coumermycin analogs of general formula I: 1

Abstract: A composite bicycle frame comprising a continuous frame tube defining cross bar, down tube, and seat tube portions. The frame tube is formed from a fiber reinforced polymer composite. Integrally connected to the frame tube are seat tube, bottom bracket, and head tube fittings. The cross bar portion of the frame tube extends between the seat tube and head tube fittings, with the down tube portion extending between the bottom bracket and head tube fittings. The seat tube portion itself extends between the seat tube and bottom bracket fittings.

Abstract: A bicycle frame has a seat tube fitting to which a seat is attachable, a head tube fitting to which forks are attachable, and a bottom bracket fitting to which a crank shaft is attachable. A single frame tube of fiber reinforced polymer composite interconnects the seat tube fitting, head tube fitting, and bottom bracket fitting in a manner which provides a lightweight, and durable bicycle frame. The single frame tube is formed by disposing the seat tube fitting, head tube fitting, and bottom bracket fitting within a first mold section, then disposing a bladder covered with polymer impregnated fiber within the first mold section such that the bladder passes through openings in the seat tube fitting, head tube fitting, and bottom bracket fitting. The bladder is then inflated while the polymer impregnated fiber is heated so as to form a fiber reinforced polymer composite which conforms to the shape of the cavity formed within the mold, thereby defining the desired bicycle frame.

Abstract: A process for preparing non-planar thermoplastic fiber reinforced composites utilizes drapeable thermoplastic impregnated fiber reinforced prepregs in a pressure thermoforming process employing but one diaphragm. The single diaphragm when initially used is flat, but becomes deformed, following its first use, to the shape of the finished part. The diaphragm thus deformed may be repeatedly used as it will still fit over the prepreg layup.