Abstract: The invention provides isolated protein kinase polypeptides related to novel brain-localized protein kinases homologous to known homeodomain-interacting protein kinases (HIPKs), and the isolated nucleic acid molecules that encode these polypeptides. The novel polypeptides and nucleic acid molecules of the invention are termed HIPK4. The invention also provides genetically engineered expression vectors, host cells, and transgenic animals comprising the novel nucleic acid molecules of the invention. The invention additionally provides antisense and RNAi molecules to the nucleic acid molecules of the invention. The invention further provides inhibitors, activators, and antibodies capable of binding to the protein kinase polypeptides of the invention, and their use in the prevention and treatment of neurological disorders.

Abstract: The present invention provides a two-piece apparatus for holding and aligning the MEMS deformable mirror. The two-piece apparatus comprises a holding plate for fixedly holding an adaptive optics element in an overall optical system and a base spatially fixed with respect to the optical system and adapted for mounting and containing the holding plate. The invention further relates to a means for configuring the holding plate through adjustments to each of a number of off-set pads touching each of three orthogonal plane surfaces on the base, wherein through the adjustments the orientation of the holding plate, and the adaptive optics element attached thereto, can be aligned with respect to the optical system with six degrees of freedom when aligning the plane surface of the optical element. The mounting system thus described also enables an operator to repeatedly remove and restore the adaptive element in the optical system without the need to realign the system once that element has been aligned.

Abstract: The present invention provides a two-piece apparatus for holding and aligning the MEMS deformable mirror. The two-piece apparatus comprises a holding plate for fixedly holding an adaptive optics element in an overall optical system and a base spatially fixed with respect to the optical system and adapted for mounting and containing the holding plate. The invention further relates to a means for configuring the holding plate through adjustments to each of a number of off-set pads touching each of three orthogonal plane surfaces on the base, wherein through the adjustments the orientation of the holding plate, and the adaptive optics element attached thereto, can be aligned with respect to the optical system with six degrees of freedom when aligning the plane surface of the optical element. The mounting system thus described also enables an operator to repeatedly remove and restore the adaptive element in the optical system without the need to realign the system once that element has been aligned.

Abstract: The present invention relates to the ZipA-binding site of FtsZ, as determined using genetic and mutagenesis techniques. In particular, the present invention provides a ZipA-binding site of FtsZ, and a molecule having a ZipA-binding site. Also disclosed are mutant FtsZ proteins. The present invention is further directed to a method for identifying an agent which interacts with FtsZ, as well as an agent that interacts with FtsZ at a binding site. Finally, the present invention discloses a method for identifying an agent that interacts with a molecule having a ZipA-binding site, as well as an agent that interacts with a molecule having a ZipA-binding site.

Abstract: An apparatus includes a manually operable air pump for providing a compressed flow of air to an air motor. An electrical generator is coupled to the air motor and is powered thereby. The generator in turn provides electrical power to a portable electrical device. In one embodiment, device is disposed in a shoe and the air pumping is manually provided by the user's walking or running. In another embodiment, the air pump comprises squeegy devices for each hand of a runner or walker.