Abstract: An apparatus may include an interface system and a first local control system. The first local control system may be configured to: receive first sensor data from a first preview environment while a content stream is being presented in the first preview environment; generate, based at least in part on the first sensor data, first user engagement data corresponding to one or more people in the first preview environment, the first user engagement data indicating estimated engagement with presented content of the content stream; output, via the interface system, either the first user engagement data, the first sensor data, or both, to a data aggregation device; and determine, based at least in part on user preference data, whether to provide at least some of the first user engagement data, at least some of the first sensor data, or both, to one or more machine learning (ML) models.

Abstract: A variable height fill station for filling containers with ready mixed compositions, includes a hopper, a dispensing nozzle in fluid communication with the hopper, an inner tube having a first inner end, and an opposite second inner end, an outer tube having a first outer end telescopingly receiving the second inner end of the inner tube, and an opposite second outer end, a support frame supporting the second outer end, and providing an actuator mounting point, and a linear actuator connected at a work end to the second inner end, and at an opposite end to the support frame, so that linear reciprocation of the actuator moves the inner tube relative to the outer tube, thus adjusting an operational height of the dispensing nozzle.

Abstract: The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions containing the compounds and their use in the treatment of kinetoplastid infections.

Abstract: The system set forth herein relates to a network of a server, proctor device and user devices that connect to provide attendance information at a gathering location. The proctor may define an area that constitutes a meeting location for a particular time. Users may connect to a network to join the meeting and when the user is within the area at a particular time, the user can authorize the transmittal of information to alter the system that the user is present. The system is able to determine the proximity of the user to identify a present status without needing to store or transmit the user's actual location to the proctor and thereby maintain a level of anonymity for the user while still confirming the user's presence at the location.

Abstract: The present invention relates to a class of novel heterocyclic compounds, to pharmaceutical compositions containing the compounds and their use in the treatment of kinetoplastid infections.

Abstract: Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.

Abstract: Compounds having the following formula (I): and pharmaceutically acceptable salts thereof, wherein A, B, D, E and R1 are as defined herein, are provided. Methods comprising the use of such compounds for the treatment of neurological disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in the treatment of neurological disorders, also are provided.

Abstract: The system set forth herein relates to a network of a server, proctor device and user devices that connect to provide attendance information at a gathering location. The proctor may define an area that constitutes a meeting location for a particular time. Users may connect to a network to join the meeting and when the user is within the area at a particular time, the user can authorize the transmittal of information to alter the system that the user is present. The system is able to determine the proximity of the user to identify a present status without needing to store or transmit the user's actual location to the proctor and thereby maintain a level of anonymity for the user while still confirming the user's presence at the location.

Abstract: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Abstract: The present invention relates to compounds of formula (I) and (IV), and pharmaceutically acceptable salts, tautomers, stereoisomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are for use in the treatment of disorders that are ameliorated by inhibition of HDAC such as cancer and hemoglobinopathies like ?-thalassemia or sickle cell anemia.

Abstract: The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

Abstract: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Abstract: The present invention relates to compounds useful for treating parasitic diseases, which are infectious diseases caused or transmitted by a parasite. Compounds of the invention are particularly active against the causative pathogens in malaria. Such compounds are selective inhibitors of parasitic histone deacetylase (PfHDAC) and suppress the growth of parasites, such as Plasmodium falciparum, at a lower concentration than the concentration required for the inhibition of the growth of mammalian cells.

Abstract: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Abstract: The present invention relates to compounds of formula (I) and (IV), and pharmaceutically acceptable salts, tautomers, stereoisomers thereof, which are inhibitors of histone deacetylase (HDAC). The compounds of the present invention are for use in the treatment of disorders that are ameliorated by inhibition of HDAC such as cancer and hemoglobinopathies like ?-thalassemia or sickle cell anemia.

Abstract: A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, Z, Y, X, M, W, n and m are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes 5 for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

Abstract: The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

Abstract: The invention provides a forceps system comprising a pair of forceps members and force measurement means operable to measure compressive and traction forces exerted by the forceps when in use, and to output measurement signals indicative of such forces. Also provided is a method of measuring the compressive and traction forces exerted by a forceps system when in use.

Abstract: A class of macrocyclic compounds of formula (I), wherein R1, R3, R4, Ra, Rb, A, B, Z, M, W and n are defined herein, that are useful as inhibitors of viral proteases, particularly the hepatitis C virus (HCV) NS3 protease, are provided. Also provided are processes for the synthesis and use of such macrocyclic compounds for treating or preventing HCV infection.

Abstract: The present invention relates to macrocyclic compounds of formula (I): wherein W, n, m, R1, R2, R3, R4, R5, Ra, M, Z and ring B are defined herein, and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising them, and their use for the treatment or prevention of infection by hepatitis C virus.