Patents by Inventor Steven Hecht
Steven Hecht has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11719607Abstract: The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening.Type: GrantFiled: November 6, 2020Date of Patent: August 8, 2023Assignee: Hologic, Inc.Inventors: Anthony P. Shuber, Steven Hecht, Erin Coffman, Paul MacLean, Howard B. Kaufman
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Publication number: 20210072125Abstract: The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. Surprisingly the presence of beads in the mixture from the partial lysing process does not interfere with slide processing or cellular analysis. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health.Type: ApplicationFiled: November 6, 2020Publication date: March 11, 2021Inventors: Anthony P. Shuber, Steven Hecht, Erin Coffman, Paul MacLean, Howard B. Kaufman
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Patent number: 10859475Abstract: The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.Type: GrantFiled: October 11, 2017Date of Patent: December 8, 2020Assignee: Hologic, Inc.Inventors: Anthony P. Shuber, Steven Hecht, Erin Coffman, Paul MacLean, Howard B. Kaufman
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Patent number: 10508977Abstract: A wash solution for remediating lubricant contamination in cytological specimens includes a Tris-based alkaline buffer solution. The buffer solution may be prepared in methanol, and may include a proton-rich protein, or a basic amino acid, such as arginine, lysine, or guanidine. A method for remediating a specimen contaminated with lubricant includes using the wash solution and/or adding a salt to the final vial prior to preparing the microscope slide. The method may include adding the wash solution to the specimen, centrifuging the specimen and wash solution to form a supernatant and cell pellet, decanting the supernatant, and adding a preservative solution to the cell pellet. The method may further include adding salt to a vial containing the preservative solution and cell pellet.Type: GrantFiled: November 21, 2016Date of Patent: December 17, 2019Assignee: HOLOGIC, INC.Inventors: Erin Coffman, Steven Hecht, Paul MacLean
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Publication number: 20180143114Abstract: A wash solution for remediating lubricant contamination in cytological specimens includes a Tris-based alkaline buffer solution. The buffer solution may be prepared in methanol, and may include a proton-rich protein, or a basic amino acid, such as arginine, lysine, or guanidine. A method for remediating a specimen contaminated with lubricant includes using the wash solution and/or adding a salt to the final vial prior to preparing the microscope slide. The method may include adding the wash solution to the specimen, centrifuging the specimen and wash solution to form a supernatant and cell pellet, decanting the supernatant, and adding a preservative solution to the cell pellet. The method may further include adding salt to a vial containing the preservative solution and cell pellet.Type: ApplicationFiled: November 21, 2016Publication date: May 24, 2018Inventors: Erin Coffman, Steven Hecht, Paul MacLean
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Publication number: 20180031453Abstract: The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.Type: ApplicationFiled: October 11, 2017Publication date: February 1, 2018Inventors: Anthony P. Shuber, Steven Hecht, Erin Coffman, Paul MacLean, Howard B. Kaufman
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Patent number: 9810610Abstract: The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health. The disclosed method streamlines the diagnostic process for protocols that require both types of assays, without compromising screening accuracy.Type: GrantFiled: September 17, 2015Date of Patent: November 7, 2017Assignee: Hologic, Inc.Inventors: Anthony P. Shuber, Steven Hecht, Erin Coffman, Paul MacLean, Howard B. Kaufman
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Publication number: 20160076980Abstract: The present disclosure describes a method of treating a sample comprising cells with a process of partial lysing. Cells are exposed to a process such as bead beating that lyses some cells in the mixture. The process generates a resultant sample mixture that is suitable for both cell morphology screening and genetic screening. A first portion of the partially lysed sample can be mounted on a slide and observed for atypical cells and cytologic abnormalities. A second portion of the partially lysed sample can be screened for genetic markers known to correlate with a risk of cervical cancer. Surprisingly the presence of beads in the mixture from the partial lysing process does not interfere with slide processing or cellular analysis. The method is particularly useful for cervical screening, where a combination of cytology and genetic screening present a more complete picture of cervical health.Type: ApplicationFiled: September 17, 2015Publication date: March 17, 2016Inventors: Anthony P. Shuber, Steven Hecht, Erin Coffman, Paul MacLean, Howard B. Kaufman
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Publication number: 20160074022Abstract: The invention provides a device, system and method for sample collection wherein a sample can be separated into multiple portions of sample at the site of collection. The separation of portions of sample occurs by separating parts of the specimen collection device. Each of the separable parts contacting a portion of sample can be deposited into separate vessels. The device reduces the risk of sample contamination, because the separable parts can be separated by the action of a release mechanism that allows a user to separate the parts without touching or otherwise contacting the sample collecting region. The release mechanism may be trigger-activated to expel a separable part of the device.Type: ApplicationFiled: September 17, 2015Publication date: March 17, 2016Inventors: Ryan Oliva, Steven Hecht, Howard B. Kaufman
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Patent number: 7422858Abstract: A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smaller than a dimension of a HPV infected cell, such that most of the HPV particles pass through the filter, while leaving the cells on the filter. The material collected on the filter is then examined to determine if HPV infected cells are present in the material.Type: GrantFiled: January 10, 2007Date of Patent: September 9, 2008Assignee: Cytyc CorporationInventors: Brian B. Lentrichia, Steven A. Hecht
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Publication number: 20070148736Abstract: A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smaller than a dimension of a HPV infected cell, such that most of the HPV particles pass through the filter, while leaving the cells on the filter. The material collected on the filter is then examined to determine if HPV infected cells are present in the material.Type: ApplicationFiled: January 10, 2007Publication date: June 28, 2007Inventors: Brian Lentrichia, Steven Hecht
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Patent number: 7198902Abstract: A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smaller than a dimension of a HPV infected cell, such that most of the HPV particles pass through the filter, while leaving the cells on the filter. The material collected on the filter is then examined to determine if HPV infected cells are present in the material.Type: GrantFiled: September 25, 2003Date of Patent: April 3, 2007Assignee: Cytyc CorporationInventors: Brian B. Lentrichia, Steven A. Hecht
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Publication number: 20060088814Abstract: The present invention relates to an aqueous alcohol buffer solution for substantially ambient, in vitro preservation of mammalian cells for a selected duration.Type: ApplicationFiled: October 21, 2005Publication date: April 27, 2006Inventors: Steven Hecht, Wendy Swinehart
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Publication number: 20050069867Abstract: A method for analyzing a sample to detect cells infected by Human Papilloma Virus (HPV) is provided. The method includes passing a medium containing the sample across a filter. The filter has a pore size that is greater than a dimension of a HPV particle, but smaller than a dimension of a HPV infected cell, such that most of the HPV particles pass through the filter, while leaving the cells on the filter. The material collected on the filter is then examined to determine if HPV infected cells are present in the material.Type: ApplicationFiled: September 25, 2003Publication date: March 31, 2005Applicant: Cytyc CorporationInventors: Brian Lentrichia, Steven Hecht
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Patent number: D580266Type: GrantFiled: April 24, 2006Date of Patent: November 11, 2008Assignee: Johnson & Johnson Consumer Companies, Inc.Inventor: Steven Hecht
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Patent number: D584620Type: GrantFiled: April 24, 2006Date of Patent: January 13, 2009Assignee: Johnson & Johnson Consumer CompaniesInventor: Steven Hecht
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Patent number: D592059Type: GrantFiled: November 7, 2008Date of Patent: May 12, 2009Assignee: Johnson & Johnson Consumer Companies, Inc.Inventor: Steven Hecht
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Patent number: D594745Type: GrantFiled: April 24, 2006Date of Patent: June 23, 2009Assignee: Johnson & Johnson Consumer Co., Inc.Inventor: Steven Hecht