Abstract: Systems and methods are disclosed that utilize metal nanostructures that are synthesized in situ along the internal surfaces of a microfluidic device. The nanostructures are formed by initial deposition of metallic seeds followed by flowing growth and reducing agent solutions into the capillaries/microfluidic channels to grow the nanostars. The nanostructures may optionally be functionalized with a capture ligand. The capture ligand may be used to selectively bind to certain cells (e.g., circulating tumor cells). The cells may be removed by a beam of light (e.g., laser beam) that induces localized heating at the surface location(s) containing the nanostructures. The plasmonic nature of the nanostructures can be used to heat the nanostructure(s) locally for the selective removal of one or certain cells. The nanostructures may be used to acquire Raman spectra of molecules or other small objects that are bound thereto for identification and quantification.

Abstract: A compact air pump and valve package includes pump and valve assemblies integral with a pressure housing defining inlet ports and a plurality of fittings for connecting air lines to an interior of the pressure housing. The linear diaphragm pump assembly has a permanent magnetic shuttle mounting two diaphragms reciprocated by an electromagnet. The valve assembly has a plurality of solenoid valves disposed within the pressure housing, each solenoid valve being operable to control flow into or out of the pressure housing through an associated one of the plurality of fittings. Thus, no tubes or hoses are required to transfer air from the pump assembly to the valves. The housing has special mounts to isolate vibration arising from movement of the shuttle.