Patents by Inventor Steven Hofstadler

Steven Hofstadler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions And Methods For Inhibiting Terminal Transferase Activity
    Publication number: 20110250648
    Abstract: The present invention relates to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification techniques having reduced 3? non-templated nucleotide addition.
    Type: Application
    Filed: April 6, 2011
    Publication date: October 13, 2011
    Applicant: lbis Biosciences, Inc.
    Inventors: Sherilynn Manalili Wheeler, James C. Hannis, Steven A, Hofstadler
  • SECONDARY STRUCTURE DEFINING DATABASE AND METHODS FOR DETERMINING IDENTITY AND GEOGRAPHIC ORIGIN OF AN UNKNOWN BIOAGENT THEREBY
    Publication number: 20110238316
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: January 9, 2004
    Publication date: September 29, 2011
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • Methods for rapid identification and quantitation of nucleic acid variants
    Patent number: 8026084
    Abstract: There is a need for nucleic acid analysis which is both specific and rapid, and in which no nucleic acid sequencing is required. The present invention addresses this need, among others by providing a method of nucleic acid amplification of overlapping sub-segments of a nucleic acid followed by molecular mass measurement of resulting amplification products by mass spectrometry, and determination of the base compositions of the amplification products.
    Type: Grant
    Filed: July 21, 2006
    Date of Patent: September 27, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Steven A. Hofstadler, Thomas A. Hall, Kristin Sannes Lowery
  • Method for rapid detection and identification of bioagents
    Patent number: 8017358
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: September 13, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Method for rapid detection and identification of bioagents
    Patent number: 8017743
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: September 13, 2011
    Assignee: Ibis Bioscience, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil
  • Method for rapid detection and identification of bioagents
    Patent number: 8017322
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: September 13, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF ENTERIC BACTERIAL PATHOGENS
    Publication number: 20110200997
    Abstract: The present invention relates generally to identification of enteric bacterial pathogens, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: May 29, 2009
    Publication date: August 18, 2011
    Applicant: IBIS Biosciences, Inc.
    Inventors: Sherilynn Manalili Wheeler, James C. Hannis, Feng Li, Raymond Ranken, Lawrence B. Blyn, David J. Ecker, Rangarajian Sampath, Steven A. Hofstadler
  • Secondary Structure Defining Database And Methods For Determining Identity And Geographic Origin Of An Unknown Bioagent Thereby
    Publication number: 20110172925
    Abstract: The present invention relates generally to the field of investigational bioinformatics and more particularly to secondary structure defining databases. The present invention further relates to methods for interrogating a database as a source of molecular masses of known bioagents for comparing against the molecular mass of an unknown or selected bioagent to determine either the identity of the selected bioagent, and/or to determine the origin of the selected bioagent. The identification of the bioagent is important for determining a proper course of treatment and/or irradication of the bioagent in such cases as biological warfare. Furthermore, the determination of the geographic origin of a selected bioagent will facilitate the identification of potential criminal identity.
    Type: Application
    Filed: October 31, 2007
    Publication date: July 14, 2011
    Applicant: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • COMPOSITIONS FOR USE IN IDENTIFICATION OF STRAINS OF E. COLI O157:H7
    Publication number: 20110166040
    Abstract: The present invention relates generally to strain typing of Escherichia coli O157:H7, and provides methods, compositions and kits useful for this purpose when combined, for example, with molecular mass or base composition analysis.
    Type: Application
    Filed: May 28, 2009
    Publication date: July 7, 2011
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: James C. Hannis, Feng Li, Rangarajan Sampath, Lawrence B. Blyn, Steven A. Hofstadler, David J. Ecker, Mark W. Eshoo
  • Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture
    Patent number: 7964343
    Abstract: The present invention provides a method for rapid solution capture purification of nucleic acids for subsequent analysis by electrospray mass spectrometry which is efficient and cost-effective relative to existing methods. The present invention also provides kits useful for practicing rapid solution capture of nucleic acids so that purified samples are in condition for analysis by electrospray mass spectrometry.
    Type: Grant
    Filed: May 12, 2004
    Date of Patent: June 21, 2011
    Assignee: Ibis Biosciences, Inc.
    Inventors: Steven A. Hofstadler, Lendell L. Cummins
  • LIFT AND MOUNT APPARATUS
    Publication number: 20110014027
    Abstract: The present invention provides devices, apparatuses, and systems for lifting and mounting of clinical- and research-related equipment. In particular, the present invention provides a lift and mount system for mass spectrometers (e.g., for time of flight (TOF) mass spectrometers (MS)).
    Type: Application
    Filed: July 15, 2010
    Publication date: January 20, 2011
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Jared J. Drader, Steven A. Hofstadler, Jose R. Gutierrez, Paul J. Gleason, Andrew J. Scherer, Rex O. Bare
  • IONIZATION PROBE ASSEMBLIES
    Publication number: 20100219336
    Abstract: The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
    Type: Application
    Filed: February 12, 2010
    Publication date: September 2, 2010
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Steven A. Hofstadler, Jose R. Gutierrez, James C. Hannis, Jared J. Drader, Rex O. Bare, Jeffrey C. Smith, Paul J. Gleason, Jared Nathanson
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 7781162
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: September 11, 2003
    Date of Patent: August 24, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke
  • REAGENTS FOR NUCLEIC ACID PURIFICATION
    Publication number: 20100190240
    Abstract: Embodiments of the present invention provide methods and kits for purifying nucleic acids. In particular, embodiments of the present invention provide methods and kits for purifying nucleic acids through the use of magnetic particles in binding buffers.
    Type: Application
    Filed: March 21, 2008
    Publication date: July 29, 2010
    Inventors: Yun Jiang, Lendell L. Cummins, Steven A. Hofstadler
  • METHODS FOR RAPID FORENSIC DNA ANALYSIS
    Publication number: 20100184035
    Abstract: The present invention provides methods and primer pairs for rapid, high-resolution forensic analysis of DNA and STR-typing by using amplification and mass spectrometry, determining the molecular masses and calculating base compositions of amplification products and comparing the molecular masses with the molecular masses of theoretical amplicons indexed in a database.
    Type: Application
    Filed: February 25, 2008
    Publication date: July 22, 2010
    Applicant: IBIS BIOSCIENCE, INC.
    Inventors: Thomas A. Hall, Steven A. Hofstadler, Kristin Sannes-Lowery
  • Method for rapid detection and identification of bioagents
    Patent number: 7741036
    Abstract: Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a “base composition signature” (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
    Type: Grant
    Filed: January 13, 2006
    Date of Patent: June 22, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven Hofstadler, John McNeil
  • Systems for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy
    Publication number: 20100145626
    Abstract: The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
    Type: Application
    Filed: October 26, 2009
    Publication date: June 10, 2010
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Thomas A. Hall, Yun Jiang, James C. Hannis, Neill White, Vivek Samant, Mark W. Eshoo, Jared J. Drader
  • MIXING CARTRIDGES, MIXING STATIONS, AND RELATED KITS, SYSTEMS, AND METHODS
    Publication number: 20100128558
    Abstract: Cartridges useful for mixing materials, such as fluidic materials are provided. A cartridge typically includes a body structure having surfaces that define a cavity with upper and lower portions. A rotatable member generally extends along a horizontal axis in the upper portion of the cavity. One or more protrusions typically extend outward from the rotatable member and into the lower portion of the cavity, and are configured to mix the material when the material is disposed in the cavity. Related mixing stations, systems, kits, and methods are also provided.
    Type: Application
    Filed: September 16, 2009
    Publication date: May 27, 2010
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Steven A. Hofstadler, Jared J. Drader, Jose R. Gutierrez, Rex O. Bare, Robert D. Miller, Jeffrey C. Smith
  • MASS SPECTROMETY WITH SELECTIVE ION FILTRATION BY DIGITAL THRESHOLDING
    Publication number: 20100127165
    Abstract: The methods described herein generally relate to characterization of large analytes, such as biomolecules, by molecular mass analysis. Specifically, the methods are directed to molecular mass analysis of singly- or multiply-charged ions by selective ion filtering carried out by a digital thresholding process.
    Type: Application
    Filed: January 26, 2010
    Publication date: May 27, 2010
    Applicant: IBIS BIOSCIENCES, INC.
    Inventors: Steven A. Hofstadler, Jared J. Drader, Amy L. Schink
  • Methods for rapid identification of pathogens in humans and animals
    Patent number: 7718354
    Abstract: The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: May 18, 2010
    Assignee: Ibis Biosciences, Inc.
    Inventors: David J. Ecker, Richard H. Griffey, Rangarajan Sampath, Steven A. Hofstadler, John McNeil, Stanley T. Crooke, Lawrence B. Blyn, Raymond Ranken, Thomas A. Hall