Abstract: Methods for identifying an ion channel modulator, a target membrane receptor modulator molecule, and other modulatory molecules are disclosed, as well as cells and vectors for use in those methods. A polynucleotide encoding target is provided in a cell under control of an inducible promoter, and candidate modulatory molecules are contacted with the cell after induction of the promoter to ascertain whether a change in a measurable physiological parameter occurs as a result of the candidate modulatory molecule.

Abstract: Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.

Abstract: An I.S. machine is disclosed which has at least one section having a mold station wherein a glass forming operation is performed within a mold which includes an opposed pair of mold halves each of which has a blank diameter which can vary within a selected range and a planar surface to be clampingly engaged with the planar surface of the other mold half at a mold centerline. The section has a mold open and closed mechanism which includes a pair of opposed displaceable mold holders for holding one or a plurality of opposed pairs of mold halves, and a drive assembly for displacing the mold holders from a selected open position, the location of which is a direct function of the dimension of the blank diameter of the mold halves supported on the mold holders, to a closed position.

Abstract: A mold half for mounting on a mold holder of a mold open and close mechanism of an I.S. machine. The mold holder includes an insert having a central locating lug on the top thereof and an annular front face. The insert also has an annular upwardly projecting rib, on either side of the lug, the outer surface thereof defining the top portion of the annular front face and inner surface thereof defining the front wall of corresponding annular groove segments. The mold half comprises a blank diameter portion, which can have a dimension within a predetermined dimensional range, to be located adjacent the annular front face of the insert proximate the lug and a two segment annular flange projecting outwardly from the blank diameter portion to be located on either side of the lug. Each of the annular flange segments includes a downwardly projecting annular lip segment for insertion into a corresponding annular groove segment on the insert.

Abstract: A method is provided for producing a gear pump/motor in a low cost and efficient manner that can effectively operate in air entrained oil without emitting undesirable noises. This is accomplished by providing bleed slots in a housing adjacent an outlet passage at a location that allows first and second intersecting cavities to be machined with the same boring tool. The bleed slots have a length defined by the distance between two adjacent teeth of first and second intermeshing gears and a cross-sectional area at the mid-point of the arcuate length that is defined by multiplying the flow of the pump at a given RPM time a derived constant. The machining of the body of the gear pump/motor is accomplished in a low cost and efficient manner to produce a gear pump/motor that operates in air entrained oil without emitting undesirable noises.

Abstract: A method and apparatus is provided for producing a gear pump/motor in a low cost and efficient manner that can effectively operate in air entrained oil without emitting undesirable noises. This is accomplished by providing bleed slots in a housing adjacent an outlet passage at a location that allows first and second intersecting cavities to be machined with the same boring tool. The bleed slots have a length defined by the distance between two adjacent teeth of first and second intermeshing gears and a cross-sectional area at the mid-point of the arcuate length that is defined by multiplying the flow of the pump at a given RPM time a derived constant. The machining of the body of the gear pump/motor is accomplished in a low cost and efficient manner to produce a gear pump/motor that operates in air entrained oil without emitting undesirable noises.

Abstract: Methods disclosed herein capitalize on the ability of DNA Structure Specific Recognition Proteins (SSRPs) to bind to genomic lesions formed by chemotherapeutic agents, particularly cisplatin-type agents. Methods are provided for predicting whether an agent that damages DNA will also be cytotoxic, and for predicting whether particular eukaryotic cells will be susceptible to killing by a genotoxic drug. A screening method is provided for identifying new genotoxic drugs that produce SSRP-recognized lesions in DNA. Methods also are provided for sensitizing particular eukaryotic cells to killing by chemotherapeutic agents, particularly cisplatin-type drugs.

Abstract: DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.

Abstract: A booster stage is positioned down-bore from the breech of a gun to contain a charge of liquid propellant that is ignited by the combustion gases of a detonated breech propellant charge trailing the projectile down the gun bore. The detonated liquid propellant increases the bore gas pressure and thus accelerates the projectile to a higher muzzle velocity.

Abstract: DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.

Abstract: A compact, retrievable and inexpensive marker buoy has a primary housing in the shape of an hourglass having a throat in the center, and a base. The primary housing has a waterproof chamber situated closer to one end than the other and a non-waterproof chamber at the opposite end. A lid at one end provides access to the waterproof chamber, which chamber contains an unattached battery, a signal receiving device, and an electrical device which are linked to a releasably attachable hook. The base has a corresponding device attached to the hook. A tether is connected from the base to the primary housing unit. A transmitter transmits the necessary command signal to the receiver from above the water.

Abstract: A weight control device (10) and method for disrupting natural mastication and transport of food at chewing surfaces of the teeth (12), to thereby impede the rate of food consumption and provide an appliance useful for weight reduction. The device comprises an doutwardly projecting wing-guard or flange (14, 15, 40), which is attached by a support collar (11) to the posterior teeth along a distal to mesial orientation. The flange (14, 15, 40) is positioned laterally of the teeth and above the chewing surfaces, with the upper portion inclined away from the teeth and the relative movement of the teeth during occlusion.