Patents by Inventor Steven J. Chapin
Steven J. Chapin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8496935Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: March 16, 2011Date of Patent: July 30, 2013Assignee: Perseid Therapeutics LLCInventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Patent number: 8491899Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: March 10, 2011Date of Patent: July 23, 2013Assignee: Perseid Therapeutics LLCInventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Patent number: 8445230Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: January 21, 2011Date of Patent: May 21, 2013Assignee: Perseid Therapeutics LLCInventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Patent number: 8318176Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: January 21, 2011Date of Patent: November 27, 2012Assignee: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Patent number: 8283447Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: January 21, 2011Date of Patent: October 9, 2012Assignee: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Patent number: 8268587Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: January 21, 2011Date of Patent: September 18, 2012Assignee: Perseid Therapeutics LLCInventors: Erik E Karrer, Madan M. Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20120135912Abstract: The invention provides novel 2D-VCAM-1 variant polypeptides and conjugates thereof that bind human VLA4. The invention also provides related polynucleotides, compositions, vectors, host cells, and methods.Type: ApplicationFiled: May 10, 2011Publication date: May 31, 2012Applicant: PERSEID THERAPEUTICS LLCInventors: MADAN M. PAIDHUNGAT, AMULYA NANISETTI, THOMAS BOUQUIN, KIM VILBOUR ANDERSEN, STEVEN J. CHAPIN, CLAUS KREBBER, RONG A. FAN, DANIEL MALASHOCK, AMY BRIDEAU-ANDERSEN, ERIK KARRER, BRUCE DEVENS, STEVEN H. BASS
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Patent number: 8071095Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: April 20, 2010Date of Patent: December 6, 2011Assignee: Perseid Therapeutics, LLCInventors: Erik E Karrer, Madan M Paidhungat, Steven H Bass, Margaret Neighbors, Juha Punnonen, Steven J Chapin
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Publication number: 20110182898Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: March 16, 2011Publication date: July 28, 2011Applicant: PERSEID THERAPEUTICS LLCInventors: ERIK E. KARRER, MADAN M. PAIDHUNGAT, STEVEN H. BASS, MARGARET NEIGHBORS, JUHA PUNNONEN, STEVEN J. CHAPIN
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Publication number: 20110177071Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: March 10, 2011Publication date: July 21, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20110166324Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: July 7, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20110159542Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: June 30, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20110130546Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20110129875Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: January 21, 2011Publication date: June 2, 2011Applicant: Perseid Therapeutics LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20100260759Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: April 20, 2010Publication date: October 14, 2010Applicant: PERSEID THERAPEUTICS LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin, Sridhar Viswanathan, Brent R. Larsen
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Patent number: 7794718Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: GrantFiled: October 15, 2008Date of Patent: September 14, 2010Assignee: Perseid Therapeutics, LLCInventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin
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Publication number: 20090258031Abstract: The invention provides immunosuppressive polypeptides and nucleic acids encoding such polypeptides. In one aspect, the invention provides mutant CTLA-4 polypeptides and nucleic acids encoding mutant CTLA-4 polypeptides. Compositions and methods for utilizing such polypeptides and nucleic acids are also provided.Type: ApplicationFiled: October 15, 2008Publication date: October 15, 2009Applicant: MAXYGEN, INC.Inventors: Erik E. Karrer, Madan M. Paidhungat, Steven H. Bass, Margaret Neighbors, Juha Punnonen, Steven J. Chapin, Sridhar Viswanathan, Brent R. Larsen
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Patent number: 7404954Abstract: The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.Type: GrantFiled: January 19, 2005Date of Patent: July 29, 2008Assignee: The Regents of the University of CaliforniaInventors: Keith E. Mostov, Steven J. Chapin, Janice Richman-Eisenstat
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Ligands directed to the non-secretory component, non-stalk region of plgR and methods of use thereof
Patent number: 6855810Abstract: The invention provides compositions and methods for specific binding to a region of the polymeric immunoglobulin receptor (pIgR) of a cell with the provisos that the ligand does not substantially bind to the most abundant form of the secretory component (SC) of pIgR present in an organ of interest of an animal of interest under physiological conditions, and does not bind to the pIgR stalk. In some embodiments, the ligand decreases cleavage of SC from the stalk by at least one-third. The ligands and methods of the invention can be used with both birds and mammals. In more preferred embodiments, the animal is a mammal. In the most preferred embodiment, the animal is a human. The ligand may be targeted into the cell or may undergo retrograde transcytosis and release at the basolateral side of the cell, and may comprise a biologically active composition.Type: GrantFiled: March 26, 2001Date of Patent: February 15, 2005Assignee: The Regents of the university of CaliforniaInventors: Keith E. Mostov, Steven J. Chapin, Janice Richman-Eisenstat -
Publication number: 20040157330Abstract: The present invention relates generally to compositions adapted to provide delivery of therapeutic, diagnostic, prophylactic, or imaging molecules across polarized cells, and methods of their use. By associating two or more targeting elements in or with the composition, one of which binds to a first cell surface component, and another that binds to a second component of the cell that is not initially available to the composition in an amount sufficient to promote effective delivery of all or a portion of the composition into and/or across polarized cells, the compositions of the present invention can provide enhanced bioavailability of medically-relevant moieties.Type: ApplicationFiled: January 9, 2004Publication date: August 12, 2004Applicant: Arizeke Pharmaceuticals, Inc.Inventors: Philip L. Sheridan, Steven J. Chapin, Derrick L. Domingo