Abstract: A method for passive damping in a steer-by-wire handwheel actuator. The method includes winding a first coil around a first tooth of a motor, winding a second coil around a first tooth of the motor, and shorting the second coil to one of an internal aspect of the motor and an external aspect of the motor.

Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.

Abstract: Technical solutions are described for diagnosing an input power supply providing power to a motor. A method includes: generating a sinusoidal stimulus signal; applying, using the input power supply, the sinusoidal stimulus signal to the motor; measuring a response to the sinusoidal stimulus signal; determining a degraded condition of the input power supply based on the response to the sinusoidal stimulus signal; and performing an action in response to determining the degraded condition of the input power supply.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

Abstract: A apparatus may be configured to select a number of windings for a motor of a handwheel actuator; short a subset of windings of the number of windings; determine a resistance value for the motor; and selectively adjust, based on a number of windings associated with the subset of windings and to tune a damping characteristic associated with the handwheel actuator, the resistance value by varying at least one of (i) a number of winding turns associates with the subset of windings, (ii) a wire diameter of associated with the subset of windings, (iii) a number of wires associated with the subset of windings and (iv) a material associated with the subset of windings.

Abstract: A single circuit board assembly for forming a vehicle-motor interface includes a first side of a board with logic modules located thereon. The single circuit board assembly also includes a second side of the board with power modules located thereon. The board includes a first plurality of layers and a second plurality of layers, and a dielectric layer disposed between adjacent layers of the first plurality of layers and/or the second plurality of layers, the dielectric layer comprising polytronics material.

Abstract: An electric machine includes a rotor structure disposed within a motor housing, wherein a second rotor end has a plurality of axially stacked laminations. The electric machine further includes a motor position sensor system which includes a first plurality of cutouts defined in the plurality of axially stacked laminations, wherein the first plurality of cutouts have a progressively smaller cross-sectional area at each lamination. The motor position sensor system also includes a second plurality of cutouts defined in the plurality of axially stacked laminations, wherein the second plurality of cutouts have a progressively smaller cross-sectional area at each lamination. The motor position sensor system further includes a plurality of motor sensors axially spaced from the second rotor end, and a plurality of sensor magnets axially spaced from the second rotor end and the plurality of motor sensors.

Abstract: Technical solutions are described for diagnosing an input power supply providing power to a motor. A method includes: generating a sinusoidal stimulus signal; applying, using the input power supply, the sinusoidal stimulus signal to the motor; measuring a response to the sinusoidal stimulus signal; determining a degraded condition of the input power supply based on the response to the sinusoidal stimulus signal; and performing an action in response to determining the degraded condition of the input power supply.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: A method includes receiving motor velocity data, and, in response to a determination that the motor velocity data indicates that a velocity of a motor is below a threshold velocity: calculating a thermal metric corresponding to a phase imbalance of the motor; identifying at least one thermal mitigation parameter based on the thermal metric; generating at least one thermal management motor position command based on the at least one thermal mitigation parameter; and selectively controlling the motor according to the thermal management motor position command.

Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.

Abstract: The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (?)-2-[(R)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (R)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.