Abstract: The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

Abstract: A method includes receiving motor velocity data, and, in response to a determination that the motor velocity data indicates that a velocity of a motor is below a threshold velocity: calculating a thermal metric corresponding to a phase imbalance of the motor; identifying at least one thermal mitigation parameter based on the thermal metric; generating at least one thermal management motor position command based on the at least one thermal mitigation parameter; and selectively controlling the motor according to the thermal management motor position command.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: An apparatus for an electronic power steering system includes a printed circuit board and a first sensor. The printed circuit board comprising: a first surface and a second surface opposite the first surface; a first processor section extending in a first direction on the first surface; a second processor section extending in a second direction opposite the first direction on the second surface; and a void disposed between the first surface and the second surface, the first processor section and the second processor section being separated by the void.

Abstract: An electric machine includes a rotor structure disposed within a motor housing, wherein a second rotor end has a plurality of axially stacked laminations. The electric machine further includes a motor position sensor system which includes a first plurality of cutouts defined in the plurality of axially stacked laminations, wherein the first plurality of cutouts have a progressively smaller cross-sectional area at each lamination. The motor position sensor system also includes a second plurality of cutouts defined in the plurality of axially stacked laminations, wherein the second plurality of cutouts have a progressively smaller cross-sectional area at each lamination. The motor position sensor system further includes a plurality of motor sensors axially spaced from the second rotor end, and a plurality of sensor magnets axially spaced from the second rotor end and the plurality of motor sensors.

Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

Abstract: A hand wheel actuator assembly, the hand wheel actuator assembly includes a motor. The hand wheel actuator assembly also includes a motor shaft coaxially aligned with a motor axis, the motor shaft rotatably coupled to the motor, and the motor configured to cause rotation of the motor shaft about the motor axis. The hand wheel actuator assembly further includes a hand wheel shaft coaxially aligned with a hand wheel axis, the hand wheel shaft spaced from and parallel to the motor shaft, wherein the motor shaft is coupled to the hand wheel shaft by a belt. The hand wheel actuator assembly yet further includes a circuit board located between the belt and the motor.

Abstract: A header assembly for a power pack assembly includes a frame. The header assembly also includes a core disposed on or within the frame. The header assembly further includes a conductor busbar extending through the core and secured to the frame, wherein the conductor busbar has a round cross-section.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

Abstract: A method for passive damping in a steer-by-wire handwheel actuator includes selecting a number of windings for a motor of a handwheel actuator; shorting a subset of windings of the number of windings, each winding of the subset of windings being disposed at an obtuse angle from each other winding of the subset of windings; determining a resistance value for the motor; selectively adjusting the resistance value based on a number of windings associated with the subset of windings; and providing, in series with the subset of windings, at least one metal-oxide-semiconductor field-effect transistor (MOSFET) configured to: vary the resistance associated with the subset of windings based on a vehicle speed; and tune a damping characteristic associated with the handwheel actuator.

Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.

Abstract: A method for passive damping in a steer-by-wire handwheel actuator. The method includes winding a first coil around a first tooth of a motor, winding a second coil around a first tooth of the motor, and shorting the second coil to one of an internal aspect of the motor and an external aspect of the motor.

Abstract: The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.

Abstract: A system for active damping in a steering system includes a multi-phase inverter circuit associated with a motor. The multi-phase inverter circuit includes a power circuit and at least one bipolar junction transistor. The system also includes a processor, and a memory. The memory includes instructions that, when executed by the processor, cause the processor to: receive a torque signal corresponding to a torque applied to a handwheel; generate a damping signal based on the torque signal; and selectively control current flow to the at least one bipolar junction transistor based on the damping signal.

Abstract: A method for passive damping in a steer-by-wire handwheel actuator. The method includes winding a first coil around a first tooth of a motor, winding a second coil around a first tooth of the motor, and shorting the second coil to one of an internal aspect of the motor and an external aspect of the motor.

Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.

Abstract: Technical solutions are described for diagnosing an input power supply providing power to a motor. A method includes: generating a sinusoidal stimulus signal; applying, using the input power supply, the sinusoidal stimulus signal to the motor; measuring a response to the sinusoidal stimulus signal; determining a degraded condition of the input power supply based on the response to the sinusoidal stimulus signal; and performing an action in response to determining the degraded condition of the input power supply.