Abstract: The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of ?-chloroalcohols from ?-chloroketones.

Abstract: A current reference generator to control a brushless motor in a motor control system is provided. The current reference generator includes a locate peak torque module that determines a maximum possible torque and a direct axis current that corresponds to the maximum possible torque based on motor parameters, a maximum voltage, a motor velocity of the brushless motor, and a sign of a torque command. A limit torque command module limits the torque command to the maximum possible torque. A locate minimum current module determines a value of the direct axis current that results in a minimum motor current. A solve current reference module generates a reference vector that satisfies the torque command as limited by the direct axis current that corresponds to the maximum possible torque and the direct axis current that results in the minimum motor current.

Abstract: A method of calculating a motor velocity in an electric power steering system comprises receiving a plurality of motor position signals from a motor position sensor of the electronic power steering system, calculating a plurality of angle difference based on the motor position signals prior to performing any filtering operations on the motor position signals, performing a linear regression analysis on the angle differences to predict an angle difference, and calculating a motor velocity based on the predicted angle difference.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of ? chloroalcohols from ? chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.

Abstract: The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.

Abstract: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

Abstract: A method for controlling the response of an electric steering system by implementing damping for over-speed conditions is disclosed. The method includes the step of determining the velocity of an electric motor within the electric steering system, and determining a voltage limit value, wherein the voltage limit value is calculated as a function of the velocity of the electric motor. The method further includes the step of associating the voltage limit value with a motor voltage command in order to produce a limited voltage command, and applying the limited voltage command to the motor in order to provide a braking torque to the motor.

Abstract: The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.

Abstract: The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: The present disclosure relates to the use of an amino acid dehydrogenase in combination with a cofactor regenerating system comprising a ketoreductase. In particular embodiments, the process can be used to prepare L-tert-leucine using a leucine dehydrogenase.

Abstract: The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.

Abstract: A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.

Abstract: The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of ? chloroalcohols from ? chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.

Abstract: The disclosure relates to engineered ketoreductase polypeptides and processes of using the polypeptides for production of phenylephrine.

Abstract: The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.

Abstract: An electric power steering system for a vehicle includes a motor for providing assistance in turning the wheels of the vehicle. The motor is electrically connected to a controller. The controller includes a power device, such as a power transistor, electrically connected to the motor to variably provide electric power to the motor as needed. The controller also includes a gate drive device electrically connected to the power device for regulating operation the power device. A shutdown mechanism is electrically connected between the gate drive device and a power input. In the event of a fault, the shutdown mechanism isolates electrical power from the gate drive device. This prevents the power device from providing electric power to the power steering motor.

Abstract: The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.

Abstract: Disclosed herein is an apparatus that relates to a gear set. The apparatus includes, a housing, a first gear movable in the housing such that a first axis defined by the first gear is repositionable relative to the housing, a second gear in mesh with the first gear, and a second axis defined by the second gear. The apparatus constrains movement of the first axis to a plane containing both the first axis and a line commonly perpendicular to the first axis and the second axis, and a biasing member that urges the first gear toward the second gear.