Patents by Inventor Steven J. D. Karlish

Steven J. D. Karlish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Patent number: 11077128
    Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: August 3, 2021
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
  • Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure
    Patent number: 10668094
    Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.
    Type: Grant
    Filed: July 19, 2016
    Date of Patent: June 2, 2020
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
  • Selective inhibitors of ?2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure and as cardiotonic agents
    Patent number: 9938316
    Abstract: The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the ?2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: April 10, 2018
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Adriana Katz, Daniel M. Tal, Arie Marcovich
  • Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same
    Patent number: 7888059
    Abstract: A composition of matter comprising active Na,K-ATPase is disclosed, each Na,K-ATPase comprising an ? and ? subunit, the Na,K-ATPase being at least 85% purified. Methods of purifying same and uses thereof are also disclosed.
    Type: Grant
    Filed: October 4, 2007
    Date of Patent: February 15, 2011
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Steven J. D. Karlish, Haim Garty, Yael Lifshitz, Rivka Goldschleger