Patents by Inventor Steven J Feinmark

Steven J Feinmark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Two Pore Channels as a Therapeutic Target to Protect Against Myocardial Ischemia and as an Adjuvant in Cardiac Surgery
    Publication number: 20140113314
    Abstract: The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarction or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
    Type: Application
    Filed: November 29, 2012
    Publication date: April 24, 2014
    Applicants: The Research Foundation of State University of New York, The Trustees of Columbia University in the City of New York
    Inventors: Ira S. Cohen, Zhongju Lu, Richard B. Robinson, Irvin B. Krukenkamp, Peter R. Brink, Steven J. Feinmark
  • Two-pore channels as regulators of proliferation in cancer
    Publication number: 20130040298
    Abstract: The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
    Type: Application
    Filed: October 7, 2012
    Publication date: February 14, 2013
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Steven J. Feinmark, Richard B. Robinson
  • Two pore channels as regulators of proliferation in cancer
    Patent number: 8309528
    Abstract: The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
    Type: Grant
    Filed: May 9, 2007
    Date of Patent: November 13, 2012
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Steven J. Feinmark, Richard B. Robinson
  • Method of treating a condition associated with phosphorylation of TASK-1
    Patent number: 8097650
    Abstract: This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of the invention the agent is a TREK-1 agonist.
    Type: Grant
    Filed: August 2, 2006
    Date of Patent: January 17, 2012
    Assignee: The Trustees of Columbia University In The City of New York
    Inventors: Steven J Feinmark, Richard B Robinson
  • TWO PORE CHANNELS AS A THERAPEUTIC TARGET TO PROTECT AGAINST MYOCARDIAL ISCHEMIA AND AS AN ADJUVANT IN CARDIAC SURGERY
    Publication number: 20100048650
    Abstract: The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarcation or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
    Type: Application
    Filed: April 4, 2007
    Publication date: February 25, 2010
    Inventors: Ira S. Cohen, Zhongju Lu, Irvin Krukenkamp, Peter R. Brink, Richard B. Robinson, Steven J. Feinmark
  • Method of treating a condition associated with phosphorylation of TASK-1
    Publication number: 20070259051
    Abstract: This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of the invention the agent is a TREK-1 agonist.
    Type: Application
    Filed: August 2, 2006
    Publication date: November 8, 2007
    Inventors: Steven J. Feinmark, Richard B. Robinson