Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to MeCP2 loss and/or misfunction, including RETT syndrome. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a MeCP2 polypeptide.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.

Abstract: A system and method for estimating vascular flow using CT imaging include a computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to acquire a first set of data comprising anatomical information of an imaging subject, the anatomical information comprises information of at least one vessel. The instructions further cause the computer to process the anatomical information to generate an image volume comprising the at least one vessel, generate hemodynamic information based on the image volume, and acquire a second set of data of the imaging subject. The computer is also caused to generate an image comprising the hemodynamic information in combination with a visualization based on the second set of data.

Abstract: Methods for treating IBD or an IBD related disorder in a subject in need thereof are provided that comprise combined intrathecal administration of a polynucleotide comprising a CLN1 open reading frame and intravenous administration of the polynucleotide. The polynucleotide comprising the CLN1 open reading frame is a wild-type CLN1 polynucleotide. In another aspect, the polynucleotide comprising the CLN1 open reading frame comprises codon-optimized polynucleotide sequence of the polynucleotide or its complement and is codon-optimized for expression in a human cell.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and/or disorders in a subject, including, but not limited to neurological disorders such as giant axonal neuropathy. The methods described herein include direct administration of a gene therapy (e.g. an rAAV viral vector) to a subject via injection into a vagus nerve (e.g. the left vagus nerve) of the subject.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to MeCP2 loss and/or misfunction, including RETT syndrome. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a MeCP2 polypeptide.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SLC6A1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a GAT1 polypeptide.

Abstract: The present disclosure provides methods and compositions for the treatment of diseases and genetic disorders linked to SURF1 loss and/or misfunction. The methods and compositions of the present disclosure comprise rAAV vectors and rAAV viral vectors comprising transgene nucleic acid molecules comprising nucleic acid sequences encoding for a SURF1 polypeptide.

Abstract: A system and method for estimating vascular flow using CT imaging include a computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to acquire a first set of data comprising anatomical information of an imaging subject, the anatomical information comprises information of at least one vessel. The instructions further cause the computer to process the anatomical information to generate an image volume comprising the at least one vessel, generate hemodynamic information based on the image volume, and acquire a second set of data of the imaging subject. The computer is also caused to generate an image comprising the hemodynamic information in combination with a visualization based on the second set of data.

Abstract: A system and method for estimating vascular flow using CT imaging include a computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to acquire a first set of data comprising anatomical information of an imaging subject, the anatomical information comprises information of at least one vessel. The instructions further cause the computer to process the anatomical information to generate an image volume comprising the at least one vessel, generate hemodynamic information based on the image volume, and acquire a second set of data of the imaging subject. The computer is also caused to generate an image comprising the hemodynamic information in combination with a visualization based on the second set of data.

Abstract: A system and method for estimating vascular flow using CT imaging include a computer readable storage medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to acquire a first set of data comprising anatomical information of an imaging subject, the anatomical information comprises information of at least one vessel. The instructions further cause the computer to process the anatomical information to generate an image volume comprising the at least one vessel, generate hemodynamic information based on the image volume, and acquire a second set of data of the imaging subject. The computer is also caused to generate an image comprising the hemodynamic information in combination with a visualization based on the second set of data.

Abstract: The present invention is a detection system and method for using the detection system in radiant energy imaging systems. In particular, the present invention is an improved detection system employing multiple screens for greater detection efficiency. And more particularly, the present invention is a detection system for detecting electromagnetic radiation having an enclosure having four adjacent walls, connected to each other at an angle and forming a rectangle and interior portion of the enclosure, a front side area and a back side area formed from the four adjacent walls and located at each end of the enclosure, at least two screens, that further include an active area for receiving and converting electromagnetic radiation into light, and a photodetector, positioned in the interior portion of the enclosure, having an active area responsive to the light.

Abstract: The present invention is a detection system and method for using the detection system in radiant energy imaging systems. In particular, the present invention is an improved detection system employing multiple screens for greater detection efficiency. And more particularly, the present invention is a detection system for detecting electromagnetic radiation having an enclosure having four adjacent walls, connected to each other at an angle and forming a rectangle and interior portion of the enclosure, a front side area and a back side area formed from the four adjacent walls and located at each end of the enclosure, at least two screens, that further include an active area for receiving and converting electromagnetic radiation into light, and a photodetector, positioned in the interior portion of the enclosure, having an active area responsive to the light.

Abstract: An apparatus and method for operating an appliance in an energy conservation mode is described. The appliance includes a number of peripheral devices and auxiliary components ancillary to main operation of the appliance, and the method includes reducing power to at least some of the peripheral devices and auxiliary components in an energy conservation mode, thereby reducing energy consumption by the peripheral devices and auxiliary components.

Abstract: An apparatus and method for operating an appliance in an energy conservation mode is described. The appliance includes a number of peripheral devices and auxiliary components ancillary to main operation of the appliance, and the method includes reducing power to at least some of the peripheral devices and auxiliary components in an energy conservation mode, thereby reducing energy consumption by the peripheral devices and auxiliary components.

Abstract: Apparatus and methods for controlling operation of an oven by differentiating between normal temperature cycling and an abnormal event in which the temperature drifts substantially below the lower band limit are described. Such differentiation enables use of differentiated modes to bring the oven temperature back to within a tolerance band or range. Particularly, and in connection with an oven including a microcomputer, a relatively low heat rate mode is used to maintain the oven temperature within the tolerance band or range, and a relatively high heat rate mode is utilized to return the oven temperature back to within the tolerance band or range quickly if the temperature drops below a lower set limit indicative of the occurrence of a drift event. The microcomputer is programmed so that after completion of preheating, the oven temperature is controlled by the user set temperature and offsets. Power cycling of the bake and broil heaters is controlled according to timing defined by prestored parameters.

Abstract: A binocular kaleidoscope for producing multiple images is disclosed. The kaleidoscope provides a viewing channel having converging interior reflective surfaces with angled apertures converging toward the line of convergence of the reflective surfaces. Rotatable disks are mounted substantially normal to the angled apertures between the reflective surfaces and reflective sidewalls for completing the viewing channel. A housing and stand for the binocular kaleidoscope is disclosed as are methods for producing images by using the invention.

Abstract: A control system for providing power to independently driven wheels of a power driven cart for transporting medical diagnostic equipment. A manually engageable handle is mounted to the cart in a position allowing a person to exert a manual force on the handle in a direction in which it is desired for the cart to move. Force sensors are coupled to the handle to sense the manual force applied to it in a plane parallel to the plane on which the cart is to be moved. The force sensors provide signals representative of the magnitude and direction of the manual force applied to the handle in forward, reverse and turning directions. Electronic circuits are coupled to the force sensors for providing control signals to motors driving the wheels of the cart for independently controlling direction and velocity of movement of the cart.

Abstract: A switch actuating device adapted for conjoint rotation with a rotatable assembly of a prime mover. Means for mounting to the rotatable assembly so as to be conjointly rotatable therewith includes a pair of sets of opposite surfaces, and switch operating means conjointly rotatable with the mounting means is arranged for axial movement thereon between a pair of opposite positions. A pair of centrifugal weight members are responsive to the rotational speed of the device to effect the axial movement of the switch operating means between its opposite positions and include a pair of sets of means arranged for guiding engagement on the oppposite surface set pair upon the axial movement of the switch operating means between its opposite positions, respectively. A pair of springs are respectively biased between the centrifugal members.A method of assembling a switch actuating device is also disclosed.