Patents by Inventor Steven J. Henriksen

Steven J. Henriksen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to cortistatin: neuropeptides, compositions and methods
    Patent number: 6814967
    Abstract: The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.
    Type: Grant
    Filed: January 18, 2001
    Date of Patent: November 9, 2004
    Assignee: The Scripps Research Institute
    Inventors: J. Gregor Sutcliffe, Luis De Lecea, Steven J. Henriksen, George R. Siggins
  • Cortistatin: neuropeptides
    Patent number: 6479642
    Abstract: The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.
    Type: Grant
    Filed: May 15, 1997
    Date of Patent: November 12, 2002
    Assignee: The Scripps Research Institute
    Inventors: J. Gregor Sutcliffe, Luis De Lecea, Steven J. Henriksen, George R. Siggins
  • Cortistatin: neuropeptides, compositions and methods
    Publication number: 20020133000
    Abstract: The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.
    Type: Application
    Filed: January 30, 2002
    Publication date: September 19, 2002
    Inventors: J. Gregor Sutcliffe, Luis De Lecea, Steven J. Henriksen, George R. Siggins
  • Cortistatin: neuropeptides, compositions and methods
    Publication number: 20020013456
    Abstract: The present invention relates generally to nucleic acids encoding a novel neuropeptide designated cortistatin. The cortistatin nucleic acids, proteins and polypeptides thereof along with anti-cortistatin antibodies are useful in both screening methods, diagnostic methods and therapeutic methods related to modulation of sleep and disorders thereof.
    Type: Application
    Filed: January 18, 2001
    Publication date: January 31, 2002
    Applicant: The Scripps Research Institute
    Inventors: J. Gregor Sutcliffe, Luis De Lecea, Steven J. Henriksen, George R. Siggins
  • Inhibitors of oleamide hydrolase
    Patent number: 6096784
    Abstract: Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding .alpha.-keto ethyl ester 8 (1.4 nM) and the trifluoromethyl ketone inhibitor 12 (1.2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.
    Type: Grant
    Filed: January 5, 1999
    Date of Patent: August 1, 2000
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Chi-Huey Wong, Dale L. Boger, Steven J. Henriksen
  • Inhibitors of oleamide hydrolase
    Patent number: 5856537
    Abstract: Inhibitors of oleamide hydrolase, responsible for the hydrolysis of an endogenous sleep-inducing lipid (1, cis-9-octadecenamide) were designed and synthesized. The most potent inhibitors possess an electrophilic carbonyl group capable of reversibly forming a (thio) hemiacetal or (thio) hemiketal to mimic the transition state of a serine or cysteine protease catalyzed reaction. In particular, the tight binding .alpha.-keto ethyl ester 8 (1.4 nM) and the trifluoromethyl ketone inhibitor 12 (1.2 nM) were found to have exceptional inhibitory activity. In addition to the inhibitory activity, some of the inhibitors displayed agonist activity which resulted in the induction of sleep in laboratory animals.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: January 5, 1999
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Chi-Huey Wong, Dale L. Boger, Steven J. Henriksen
  • Method for sleep induction
    Patent number: 5612380
    Abstract: Sleep may be induced by administration of fatty acid primary amides, including cis-9,10-octadecenoamide. Furthermore, sleep deprivation may be assayed by analyzing cerebrospinal fluid with respect to the presence of fatty acid primary amides, including cis-9,10-octadecenoamide. The presence of cis-9,10-octadecenoamide in cerebrospinal fluid is correlated with comparative sleep deprivation.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: March 18, 1997
    Assignee: The Scripps Research Institute
    Inventors: Richard A. Lerner, Dale Boger, Ben Cravatt, Gary E. Siuzdak, Steven J. Henriksen