Abstract: A manufacturing system (20) comprises: one or more stores (84; 80A-80C; 92) for raw materials, work-in-progress (WIP), and finished goods; a plurality of manufacturing cells (40A-40F), each cell includes: one or more machines (42A-42C) for manufacturing an assembly; and a programmable logic controller (PLC) (44) for controlling the machines; one or more devices (60, 70) for moving raw material, WIP, and finished goods; and one or more servers (32) for communicating with the PLCs and the devices. The one or more servers further have programming for: instructing (642) the plurality of manufacturing cells to assemble finished goods from the raw materials; instructing (628, 632) the one or more devices to move said raw materials and finished goods; and just in sequence (JIS) skipped assembly recovery steps (730) for the manufacturing cells and devices.

Abstract: Chemical structures have been identified which allosterically modify pyrvate kinase and inhibit enzymatic activity. These compounds can be used as pharmaceuticals in the treatment of a wide variety of diseases and disorders where influencing metabolic processes is beneficial, such as the glycolytic pathway, all pathways which use ATP as an energy source, and all pathways which involve 2,3-diphosphoglycerate related to the delivery of oxygen by modifying hemoglobin's oxygen affinity, treatments of tumor and cancer and Alzheimer's disease (AD).