Patents by Inventor Steven J. Mehrman

Steven J. Mehrman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline form of (2S)-(-)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide
    Patent number: 8809385
    Abstract: The present invention is directed to a novel crystalline form of (2S)-(?)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and related disorders; epileptogenesis; glucose related disorders; lipid related disorders; migraine; obesity; pain; substance abuse; or for neuroprotection. The present invention is further directed to a process for the preparation of the novel crystalline form.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: August 19, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Steven J. Mehrman, Wenju Wu
  • Salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one
    Patent number: 8703948
    Abstract: The present invention is directed to salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by NOP, for example depression, anxiety, alcohol abuse, etc. The present invention is further directed to process(es) for the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one and its corresponding salts.
    Type: Grant
    Filed: November 14, 2007
    Date of Patent: April 22, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Steven J. Mehrman, Armin Roessler, Roger Faessler, Frank J. Villani, Jean Francois Alexandre Lucas
  • Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
    Patent number: 8669288
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: March 11, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman, Armin Roessler
  • Process for preparation of sulfamide derivatives
    Patent number: 8283478
    Abstract: The present invention is directed to novel process for the preparation of sulfonylimine and sulfamide derivatives.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: October 9, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman
  • NOVEL LYSINE SALTS OF 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACID DERIVATIVES
    Publication number: 20110105616
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Application
    Filed: March 18, 2010
    Publication date: May 5, 2011
    Inventors: AHMED F. ABDEL-MAGID, STEVEN J. MEHRMAN, ARMIN ROESSLER
  • Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
    Patent number: 7709682
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: May 4, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman, Armin Roessier
  • CRYSTALLINE FORM OF (2S)-(-)-N-(6-CHLORO-2,3-DIHYDRO-BENZO[1,4]DIOXIN-2-YLMETHYL)-SULFAMIDE
    Publication number: 20090318544
    Abstract: The present invention is directed to a novel crystalline form of (2S)-(?)-N-(6-chloro-2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-sulfamide, pharmaceutical compositions containing said crystalline form and the use of said crystalline form in the treatment of anxiety and related disorders; bipolar depression and mania; depression; epilepsy and related disorders; epileptogenesis; glucose related disorders; lipid related disorders; migraine; obesity; pain; substance abuse; or for neuroprotection. The present invention is further directed to a process for the preparation of the novel crystalline form.
    Type: Application
    Filed: June 19, 2009
    Publication date: December 24, 2009
    Inventors: Steven J. Mehrman, Wenju Wu
  • PROCESS FOR THE PREPARATION OF BENZO-FUSED HETEROARYL SULFAMATES
    Publication number: 20090247617
    Abstract: The present invention is directed to a process for the preparation of benzo-fused heteroaryl sulfamates, useful for the treatment of epilepsy and related disorders.
    Type: Application
    Filed: March 26, 2008
    Publication date: October 1, 2009
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman
  • PROCESS FOR THE PREPARATION OF SULFAMIDE DERIVATIVES
    Publication number: 20090182141
    Abstract: The present invention is directed to novel processes for the preparation of sulfamide derivatives, useful in the treatment of epilepsy and related disorders.
    Type: Application
    Filed: January 6, 2009
    Publication date: July 16, 2009
    Inventors: Ahmed Abdel-Magid, Steven J. Mehrman, Caterina Ferraro
  • PROCESS FOR THE PREPARATION OF SULFAMIDE DERIVATIVES
    Publication number: 20090176996
    Abstract: The present invention is directed to novel processes for the preparation of sulfamide derivatves, useful in the treatment of epilepsy and related disorders.
    Type: Application
    Filed: January 7, 2009
    Publication date: July 9, 2009
    Inventors: Ahmed Abdel-Magid, Steven J Mehrman, Caterina Ferraro
  • SALTS OF 3-(3-AMINO-2-(R)-HYDROXY-PROPYL)-1-(4-FLUORO-PHENYL)-8-(8-METHYL-NAPHTHALEN-1-YLMETHYL)-1,3,8-TRIAZA-SPIRO[4.5]DECAN-4-ONE
    Publication number: 20080176882
    Abstract: The present invention is directed to salts of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by NOP, for example depression, anxiety, alcohol abuse, etc. The present invention is further directed to process(es) for the preparation of 3-(3-amino-2-(R)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one and its corresponding salts.
    Type: Application
    Filed: November 14, 2007
    Publication date: July 24, 2008
    Inventors: Steven J. MEHRMAN, Armin Roessler, Roger Faessler, Frank J. Villani, Jean Francois Alexandre Lucas Hegyi