Patents by Inventor Steven J. MEIER

Steven J. MEIER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELL CULTURE COMPOSITIONS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20240093143
    Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 21, 2024
    Applicant: GENENTECH, INC.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Melissa S. Mun, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
  • PREDICTION OF VIABILITY OF CELL CULTURE DURING A BIOMOLECULE MANUFACTURING PROCESS
    Publication number: 20240084240
    Abstract: A method, system, and non-transitory computer readable medium for predicting cell viability of a cell culture in a bioreactor during a biomolecule manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing molecules are input into a machine learning model that is trained to predict cell viabilities. The trained machine learning model may then analyze the at least three manufacturing process parameters to generate an indicator of cell viability of the cell culture.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 14, 2024
    Applicant: GENENTECH, INC.
    Inventors: Arthi NARAYANAN, Aditya Avdhut WALVEKAR, Georo L. ZHOU, Nicholas RUMMEL, Zheng LI, Steven J. MEIER
  • PREDICTION OF DISTRIBUTION OF GLYCANS ATTACHED TO MOLECULES MANUFACTURED IN A CELL CULTURE
    Publication number: 20240084241
    Abstract: A method, system, and non-transitory computer readable medium for predicting a glycan distribution of one or more glycans attached to molecules during a biomolecules manufacturing process are disclosed. In various embodiments, at least three manufacturing process parameters related to the process for manufacturing the molecules are input into a probabilistic graphical model that is trained to predict glycan distribution. The trained probabilistic graphical model may then analyze the at least three manufacturing process parameters to predict the distribution of the glycans that are attached to the molecules.
    Type: Application
    Filed: September 8, 2023
    Publication date: March 14, 2024
    Applicant: GENENTECH, INC.
    Inventors: Arthi NARAYANAN, Aditya Avdhut WALVEKAR, Georo L. ZHOU, Nicholas RUMMEL, Zheng LI, Steven J. MEIER
  • Methods of preparing a poloxamer for use in cell culture medium
    Patent number: 11912823
    Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: February 27, 2024
    Assignee: Genentech, Inc.
    Inventors: Ganesh Prasadh Vissvesvaran, Robert David Kiss, Steven J. Meier, Inchan Kwon, Kara Calhoun, Kate Winchester, Amelia Adams, Marion Glenn, Stefan Koenig, Alan Deese
  • CELL CULTURE COMPOSITIONS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20240052392
    Abstract: Cell culture media, such as chemically defined cell culture media, are provided, as are methods of using the media for cell growth (i.e., cell culture) and polypeptide (e.g., antibody) production. Compositions comprising polypeptides produced by the methods are also provided.
    Type: Application
    Filed: October 20, 2023
    Publication date: February 15, 2024
    Applicant: GENENTECH, INC.
    Inventors: Steven J. Meier, Melissa S. Mun, Natarajan Vijayasankaran, Sharat Varma, Yi Yang, Boyan Zhang, Silvana R. Arevalo, Martin Gawlitzek, Veronica Carvalhal
  • pH ADJUSTMENT TO IMPROVE THAW RECOVERY OF CELL BANKS
    Publication number: 20220151221
    Abstract: Provided herein are methods of freezing mammalian cells for storage or improving thaw recovery of cell banks comprising freezing mammalian cells in a freezing medium having a pH of 6.7 to 8.5.
    Type: Application
    Filed: October 8, 2021
    Publication date: May 19, 2022
    Applicant: Genentech, Inc.
    Inventors: Angela Meier, Steven J. Meier, Phillip Duffy, Marcia Coyne, Kara Calhoun
  • METHODS OF PREPARING A POLOXAMER FOR USE IN CELL CULTURE MEDIUM
    Publication number: 20210371587
    Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.
    Type: Application
    Filed: May 13, 2021
    Publication date: December 2, 2021
    Applicant: Genentech, Inc.
    Inventors: Ganesh Prasadh VISSVESVARAN, Robert David KISS, Steven J. MEIER, Inchan KWON, Kara CALHOUN, Kate WINCHESTER, Amelia ADAMS, Marion GLENN, Stefan KOENIG, Alan DEESE
  • Methods of preparing a poloxamer for use in cell culture medium
    Patent number: 11034793
    Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: June 15, 2021
    Assignee: Genentech, Inc.
    Inventors: Ganesh Prasadh Vissvesvaran, Robert David Kiss, Steven J. Meier, Inchan Kwon, Kara Calhoun, Kate Winchester, Amelia Adams, Marion Glenn, Stefan Koenig, Alan Deese
  • CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20210017488
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Application
    Filed: October 5, 2020
    Publication date: January 21, 2021
    Applicant: Genentech, Inc.
    Inventors: Natarajan VIJAYASANKARAN, Steven J. MEIER, Sharat VARMA, Yi YANG
  • Cell culture compositions with antioxidants and methods for polypeptide production
    Patent number: 10829732
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: November 10, 2020
    Assignee: Genentech, Inc.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Sharat Varma, Yi Yang
  • pH ADJUSTMENT TO IMPROVE THAW RECOVERY OF CELL BANKS
    Publication number: 20200315162
    Abstract: Provided herein are methods of freezing mammalian cells for storage or improving thaw recovery of cell banks comprising freezing mammalian cells in a freezing medium having a pH of 6.7 to 8.5.
    Type: Application
    Filed: February 21, 2020
    Publication date: October 8, 2020
    Applicant: Genentech, Inc.
    Inventors: Angela MEIER, Steven J. MEIER, Phillip DUFFY, Marcia COYNE, Kara CALHOUN
  • Cell culture compositions with antioxidants and methods for polypeptide production
    Patent number: 10676710
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: June 9, 2020
    Assignee: Genentech, Inc.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Sharat Varma, Yi Yang
  • PH adjustment to improve thaw recovery of cell banks
    Patent number: 10602739
    Abstract: Provided herein are methods of freezing mammalian cells for storage or improving thaw recovery of cell banks comprising freezing mammalian cells in a freezing medium having a pH of 6.7 to 8.5.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: March 31, 2020
    Assignee: Genentech, Inc.
    Inventors: Angela Meier, Steven J. Meier, Phillip Duffy, Marcia Coyne, Kara Calhoun
  • CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20190144817
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Application
    Filed: October 4, 2018
    Publication date: May 16, 2019
    Applicant: Genentech, Inc.
    Inventors: Natarajan VIJAYASANKARAN, Steven J. MEIER, Sharat VARMA, Yi YANG
  • CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20190002822
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Application
    Filed: June 4, 2018
    Publication date: January 3, 2019
    Applicant: Genentech, Inc.
    Inventors: Natarajan VIJAYASANKARAN, Steven J. MEIER, Sharat VARMA, Yi YANG
  • Cell culture compositions with antioxidants and methods for polypeptide production
    Patent number: 10131873
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 20, 2018
    Assignee: GENENTECH, INC.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Sharat Varma, Yi Yang
  • Cell culture compositions with antioxidants and methods for polypeptide production
    Patent number: 10017732
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: July 10, 2018
    Assignee: GENENTECH, INC.
    Inventors: Natarajan Vijayasankaran, Steven J. Meier, Sharat Varma, Yi Yang
  • PH ADJUSTMENT TO IMPROVE THAW RECOVERY OF CELL BANKS
    Publication number: 20170112122
    Abstract: Provided herein are methods of freezing mammalian cells for storage or improving thaw recovery of cell banks comprising freezing mammalian cells in a freezing medium having a pH of 6.7 to 8.5.
    Type: Application
    Filed: January 5, 2017
    Publication date: April 27, 2017
    Inventors: Angela MEIER, Steven J. MEIER, Phillip DUFFY, Marcia COYNE, Kara CALHOUN
  • METHODS OF PREPARING A POLOXAMER FOR USE IN CELL CULTURE MEDIUM
    Publication number: 20170009015
    Abstract: Provided herein are methods of preparing a poloxamer for use in a cell culture medium. Also provided herein are cell culture media containing the poloxamer prepared by the methods herein, as well as methods of using the media for cell culturing and polypeptide production from cells.
    Type: Application
    Filed: September 22, 2016
    Publication date: January 12, 2017
    Applicant: Genentech, Inc.
    Inventors: Ganesh Prasadh VISSVESVARAN, Robert David KISS, Steven J. MEIER, Inchan KWON, Kara CALHOUN, Kate WINCHESTER, Amelia ADAMS, Marion GLENN, Stefan KOENIG, Alan DEESE
  • CELL CULTURE COMPOSITIONS WITH ANTIOXIDANTS AND METHODS FOR POLYPEPTIDE PRODUCTION
    Publication number: 20160002593
    Abstract: Cell culture media comprising antioxidants are provided herein as are methods of using the media for cell culturing and polypeptide production from cells. Compositions comprising polypeptides, such as therapeutic polypeptides, produced by the methods herein are also provided.
    Type: Application
    Filed: September 11, 2015
    Publication date: January 7, 2016
    Applicant: GENENTECH, INC.
    Inventors: Natarajan VIJAYASANKARAN, Steven J. MEIER, Sharat VARMA, Yi YANG