Patents by Inventor Steven J. Saul

Steven J. Saul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20100285572
    Abstract: An aspect of the disclosure is a method and device for the detection of antibiotics in a sample. Embodiments include a microbial culture with growth indicators and sensitivity adjustment reagents. Adjustment reagents include a variety of antibiotic binders that can be added to microbial culture to reduce sensitivity to certain antibiotics. Some embodiments include multiple buffers with a variety of pKa ranges. Some embodiments also include a complete self-contained apparatus for sampling and testing.
    Type: Application
    Filed: July 26, 2010
    Publication date: November 11, 2010
    Inventors: Robert S. Salter, Steven J. Saul, Martin T. Rossi
  • Publication number: 20100285610
    Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
    Type: Application
    Filed: July 23, 2010
    Publication date: November 11, 2010
    Inventors: Steven J. Saul, Mark E. Tess, Robert J. Markovsky
  • Patent number: 7824878
    Abstract: Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to noise ratio. The maximum signal to noise ratio can be particularly useful with recombinant luciferase including recombinant Coleoptera luciferase.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: November 2, 2010
    Assignee: Charm Sciences, Inc.
    Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
  • Patent number: 7785899
    Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
    Type: Grant
    Filed: February 16, 2006
    Date of Patent: August 31, 2010
    Assignee: Charm Sciences, Inc.
    Inventors: Steven J. Saul, Mark E. Tess, Robert J. Markovsky
  • Patent number: 7632928
    Abstract: An antibody and immunogen for generating an antibody to nitrofuran and/or nitrofuran metabolite such as tissue or protein bound nitrofuran metabolites. Nitrofurans and and/or nitrofuran metabolites in a biological sample can be detected by contacting the sample with the antibodies to form a complex that can be detected. The antibodies may also be incorporated into test kits for the detection of nitrofuran and/or nitrofuran metabolites.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: December 15, 2009
    Assignee: Charm Sciences, Inc
    Inventors: Say-Jong Law, Stanley E. Charm, Steven J. Saul
  • Publication number: 20090148852
    Abstract: Methods are provided for sensitive detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include using a pH composition that maximizes a signal to noise ratio. The maximum signal to noise ratio can be particularly useful with recombinant luciferase including recombinant Coleoptera luciferase.
    Type: Application
    Filed: January 9, 2009
    Publication date: June 11, 2009
    Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
  • Patent number: 7494781
    Abstract: Methods, devices and systems are provided for detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. Aspects include a low pH composition for use in detecting the presence of ATP. The low pH composition can include low molarity buffers and detergents and can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction. Both the low molarity and low pH composition, and the methods for reading, calculating and interpreting luminescence, can be used with a single service hygiene monitoring format.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: February 24, 2009
    Assignee: Charm Sciences, Inc.
    Inventors: Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Steven J. Saul
  • Publication number: 20080274566
    Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
    Type: Application
    Filed: July 8, 2008
    Publication date: November 6, 2008
    Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
  • Patent number: 7410808
    Abstract: Embodiments described herein include methods and assays for detecting an analyte in a sample using a plurality of control zone capture agents. Some embodiments include detection of multiple analytes in a sample utilizing a plurality of analyte binders and a control zone containing multiple control zone capture agents. In some embodiments, the multiple control zone capture agents capture a plurality of binders within one control zone. Test results are determined by comparison of the control zone signal to a test zone signal.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: August 12, 2008
    Assignee: Charm Sciences, Inc.
    Inventors: Steven J. Saul, Robert J. Markovsky, David W. Douglas
  • Publication number: 20080160538
    Abstract: A method and device for detecting analytes in a test sample. Embodiments include methods for quantitatively detecting analytes within a range of concentrations. In an embodiment the method includes a lateral flow test strip with multiple test areas for capturing a labeled receptor to provide a detectable signal.
    Type: Application
    Filed: February 16, 2006
    Publication date: July 3, 2008
    Inventors: Steven J. Saul, Mark E. Tess, Robert J. Markovsky
  • Patent number: 7229783
    Abstract: A test method and test device for hygiene monitoring of a test sample from a biological material or a surface with a biological material to detect the presence of phosphate and glucose as a measure of hygiene by employing a swab-type, puncturable-membrane test apparatus or a lateral-flow or capillary-flow test apparatus.
    Type: Grant
    Filed: August 1, 2001
    Date of Patent: June 12, 2007
    Assignee: Charm Sciences, Inc.
    Inventors: Steven J. Saul, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Stanley E. Charm
  • Patent number: 7132249
    Abstract: Methods, devices and systems are provided for detection of adenosine triphosphate (ATP) in samples using the luciferin-luciferase reaction. An aspect of the invention includes a low molarity and low pH composition for use in detecting the presence of ATP. The low molarity and low pH composition can be used in combination with methods for reading, calculating and interpreting luminescence generated by the ATP-luciferin-luciferase reaction. Both the low molarity, low pH composition and the methods for reading, calculating and interpreting luminescence can be used with a single service hygiene monitoring format.
    Type: Grant
    Filed: May 11, 2004
    Date of Patent: November 7, 2006
    Assignee: Charm Sciences, Inc.
    Inventors: Robert S. Salter, Stanley E. Charm, Cheryl B. Francisco, Robert J. Markovsky, Steven J. Saul
  • Patent number: 7097983
    Abstract: The invention features a method of determining whether one or more members of an analyte family are present in a sample. The method makes use of a test zone binder, e.g., a receptor that can bind one or a plurality of analytes within an analyte family, the analytes family defined by similar structural binding sites. Members of an analyte family can have different detection level requirements and, therefore, additional analyte binders can be employed to adjust test sensitivity for a subset of the analytes in the analyte family individually, so that each analyte can be detected only if it is present in the sample above a predetermined threshold.
    Type: Grant
    Filed: September 24, 2001
    Date of Patent: August 29, 2006
    Assignee: Charm Sciences, Inc.
    Inventors: Robert J. Markovsky, Cheryl A. Boyer, Stanley E. Charm, Paul R. Donahue, Yael Agi Glickman, Steven J. Saul, Joan L. Scheemaker, Richard T. Skiffington, Shefali B. Trivedi, Eliezer Zomer
  • Publication number: 20040028608
    Abstract: A test method and test device for hygiene monitoring of a test sample from a biological material or a surface with a biological material to detect the presence of phosphate and glucose as a measure of hygiene by employing a swab-type, puncturable-membrane test apparatus or a lateral-flow or capillary-flow test apparatus.
    Type: Application
    Filed: August 1, 2003
    Publication date: February 12, 2004
    Inventors: Steven J Saul, Cheryl B. Francisco, Robert J. Markovsky, Robert S. Salter, Stanley E. Charm
  • Publication number: 20030207442
    Abstract: A test device for detecting the presence of a residue analyte in a sample, which test device includes a support strip and a sample-absorbing matrix attached to the support strip. The sample-absorbing matrix has a material for absorbing an amount of the sample. The test device also includes a mobile-phase support for holding a mobile-phase composition. The mobile-phase support is attached to the support strip and in contact with the sample-absorbing matrix. A mobile-phase composition is disposed on the mobile-phase support and has a receptor for binding with the analyte. The mobile-phase composition can be carried in the sample. A stationary-phase membrane is attached to the support strip and has a first membrane end in contact with the mobile-phase composition and a second membrane end. The membrane allows lateral capillary flow of the sample from the first membrane end to the second membrane end.
    Type: Application
    Filed: September 24, 2001
    Publication date: November 6, 2003
    Inventors: Robert J. Markovsky, Cheryl A. Boyer, Stanley E. Charm, Paul R. Donahue, Yael Agi Glickman, Steven J. Saul, Joan L. Scheemaker, Richard T. Skiffington, Shefali B. Trivedi, Eliezer Zomer
  • Patent number: 6475805
    Abstract: A test device, system and method, the device composed of an elongated, toothbrush-shaped, transparent, plastic housing and a lateral-flow test strip for the detection of an analyte, such as a beta-lactam in milk, in the housing, the housing having an expansion cavity to receive expanded, liquid-contacted, absorbing material in the test strip, and to control lateral flow rate and times in the test strip.
    Type: Grant
    Filed: April 4, 2000
    Date of Patent: November 5, 2002
    Assignee: Charm Sciences, Inc.
    Inventors: Stanley E. Charm, Richard Skiffington, Robert J. Markovsky, Eliezer Zomer, Steven J. Saul
  • Patent number: 6319466
    Abstract: A test device for detecting the presence of a residue analyte in a sample includes a support strip and a sample-absorbing matrix attached to the support strip. The sample-absorbing matrix has a material for absorbing an amount of the sample. The test device also includes a mobile-phase support for holding a mobile-phase composition. The mobile-phase support is attached to the support strip and in contact with the sample-absorbing matrix. A mobile-phase composition is disposed on the mobile-phase support and has a receptor for binding with the analyte. The mobile-phase composition can be carried in the sample. A stationary-phase membrane is attached to the support strip and has a first membrane end in contact with the mobile-phase composition and a second membrane end. The membrane allows lateral capillary flow of the sample from the first membrane end to the second membrane end.
    Type: Grant
    Filed: July 16, 1998
    Date of Patent: November 20, 2001
    Assignee: Charm Sciences, Inc.
    Inventors: Robert J. Markovsky, Cheryl A. Boyer, Stanley E. Charm, Paul R. Donahue, Yael Agi Glickman, Steven J. Saul, Joan L. Scheemaker, Richard T. Skiffington, Shefali B. Trivedi, Eliezer Zomer