Patents by Inventor Steven J. Wittenberger

Steven J. Wittenberger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Endothelin antagonists
    Patent number: 6462194
    Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
    Type: Grant
    Filed: May 15, 2000
    Date of Patent: October 8, 2002
    Assignee: Abbott Laboratories
    Inventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
  • Process for the preparation of matrix metalloproteinase inhibitors
    Publication number: 20020128496
    Abstract: The present invention discloses a process for the synthesis of reverse hydroxamate matrix metalloproteinase (MMP) inhibitors.
    Type: Application
    Filed: January 11, 2002
    Publication date: September 12, 2002
    Inventors: Sou-Jeng Chang, Dilinie P. Fernando, Ashok Gupta, David R. Hill, Steven J. Wittenberger
  • Process for preparing 6-o-substituted erythromycin derivatives
    Patent number: 6437106
    Abstract: In one aspect, the invention relates to a process for preparing 6-O-substituted erythromycin derivatives comprising reacting 2′-substituted and optionally 4″-substituted 9-oxime erythromycin derivatives with an alkylating agent in the presence of a palladium catalyst and phosphine. In another aspect, the invention relates to processes for preparing 6-O-substituted erythromycin ketolides using the palladium-catalyzed alkylation reaction.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: August 20, 2002
    Assignee: Abbott Laboratories
    Inventors: Eric J. Stoner, Matthew J. Peterson, Yi-Yin Ku, Russell D. Cink, Arthur J. Cooper, Mahendra N. Deshpande, Tim Grieme, Anthony R. Haight, David R. Hill, Margaret Chi-Ping Hsu, Steven A. King, Marvin Robert Leanna, Elaine C. Lee, Maureen A. McLaughlin, Howard E. Morton, James J. Napier, Daniel J. Plata, Prasad S. Raje, Michael Rasmussen, David Riley, Jien-Heh J. Tien, Steven J. Wittenberger
  • Preparation of quinoline-substituted carbonate and carbamate derivatives
    Patent number: 6417366
    Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: July 9, 2002
    Assignee: Abbott Laboratories
    Inventors: Michael S. Allen, Ramiya H. Premchandran, Sou-Jen Chang, Stephen Condon, John A. DeMattei, Steven A. King, Lawrence Kolaczkowski, Sukumar Manna, Paul J. Nichols, Hemant H. Patel, Subhash R. Patel, Daniel J. Plata, Eric J. Stoner, Jien-Heh J. Tien, Steven J. Wittenberger
  • Treatment of diseases using endothelin antagonists
    Patent number: 6380241
    Abstract: A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: April 30, 2002
    Assignee: Abbott Laboratories
    Inventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
  • Preparation of quinoline-substituted carbonate and carbamate derivatives
    Publication number: 20020013468
    Abstract: The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a carbonate or carbamate of formula (I) or (II) or a substrate that can be reduced to obtain the same.
    Type: Application
    Filed: March 3, 2000
    Publication date: January 31, 2002
    Inventors: Michael S. Allen, Ramiya H. Premchandran, Sou-Jen Chang, Stephen Condon, John A. DeMattei, Steven A. King, Lawrence Kolaczkowski, Sukumar Manna, Paul Nichols, Hermant H. Patel, Subhash R. Patel, Daniel J. Plata, Eric J. Stoner, Jien-Heh J. Tien, Steven J. Wittenberger
  • Stereoselective process for producing nitro compounds
    Patent number: 6329536
    Abstract: The present invention relates to producing stereoselective nitro compounds by reacting a dicarbonyl compound with a nitrostyrene compound in the presence of a catalyst complex and a base.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: December 11, 2001
    Assignee: Abbott Laboratories
    Inventors: Jianguo Ji, David M. Barnes, Steve King, Frederick A. Plagge, Steven J. Wittenberger, Ji Zhang
  • Process for the selective N-formylation of N-hydroxylamines
    Publication number: 20010031896
    Abstract: The instant invention provides a process for the selective N-formylation of N-hydroxylamines.
    Type: Application
    Filed: January 12, 2001
    Publication date: October 18, 2001
    Inventors: David R. Hill, Chi-Nung Hsiao, Ravi Kurukulasuriya, Steven J. Wittenberger
  • Endothelin antagonists
    Patent number: 6162927
    Abstract: A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: December 19, 2000
    Assignee: Abbott Laboratories
    Inventors: Martin Winn, Steven A. Boyd, Charles W. Hutchins, Hwan-Soo Jae, Andrew S. Tasker, Thomas W. von Geldern, Jeffrey A. Kester, Bryan K. Sorensen, Bruce G. Szczepankiewicz, Kenneth J. Henry, Gang Liu, Steven J. Wittenberger, Steven A. King
  • Intermediates of retroviral protease inhibiting compounds
    Patent number: 5837873
    Abstract: A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: November 17, 1998
    Assignee: Abbott Laboratories
    Inventors: Daniel W. Norbeck, Lynn M. Codacovi, Steven J. Wittenberger
  • Retroviral protease inhibiting compounds
    Patent number: 5648497
    Abstract: A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: July 15, 1997
    Assignee: Abbott Laboraotries
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Lynn M. Codacovi, Hing L. Sham, Steven J. Wittenberger
  • Retroviral protease inhibiting compounds
    Patent number: 5616714
    Abstract: A retroviral protease inhibiting compound of the formula A--X--B is disclosed. Also disclosed are a composition and method for inhibiting a retroviral protease and for treating an HIV infection. Also disclosed are processes and intermediates useful for the preparation of the retroviral protease inhibitors.
    Type: Grant
    Filed: March 24, 1995
    Date of Patent: April 1, 1997
    Assignee: Abbott Laboratories
    Inventors: Dale J. Kempf, Daniel W. Norbeck, Lynn M. Codacovi, Hing L. Sham, Steven J. Wittenberger
  • Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl) isoxazoles
    Patent number: 5559242
    Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated.
    Type: Grant
    Filed: January 25, 1996
    Date of Patent: September 24, 1996
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Yun He, Steven J. Wittenberger
  • Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(s)-pyrrolidinyl)isoxazoles
    Patent number: 5516912
    Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 14, 1996
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Yun He, Steven J. Wittenberger
  • Method of preparing enantiomerically-pure 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl) isoxazoles
    Patent number: 5424444
    Abstract: A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C.sub.1 -C.sub.3 -alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: June 13, 1995
    Assignee: Abbott Laboratories
    Inventors: Nan-Horng Lin, Yun He, Richard L. Elliott, Mukund S. Chorghade, Thomas K. J. Esch, Dieter O. Beer, Christian C. Witzig, Thomas C. Herzig, Steven J. Wittenberger, William H. Bunnelle, Bikshandar A. Narayanan, Pulla R. Singam, Alla V. Rama Rao
  • Process for the preparation of tetrazoles
    Patent number: 5284954
    Abstract: The present invention relates to a process for the preparation of 5-aryl tetrazoles of the formula: ##STR1## or a salt thereof comprising reacting an aryl nitrile with a trisubstituted silyl azide and a disubstituted tin oxide.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: February 8, 1994
    Assignee: Abbott Laboratories
    Inventors: Steven J. Wittenberger, Bikshandar A. Narayanan, Anthony R. Haight, David Scarpetti