Patents by Inventor Steven James Collier

Steven James Collier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210253537
    Abstract: A process for the production of heterocyclic quaternary ammonium salts or hydroxides is disclosed. The process comprises a continuous hydrogenation step, in which an unsaturated heterocyclic amine is reacted with hydrogen to form a saturated heterocyclic amine; a first continuous N-alkylation step, in which the saturated heterocyclic amine is alkylated to produce an intermediate saturated heterocyclic amine having an increased degree of substitution compared to the saturated heterocyclic amine; and one or more further N-alkylation steps in which the intermediate saturated heterocyclic amine is N-alkylated to the heterocyclic quaternary ammonium salt or hydroxide. A process of producing a saturated heterocyclic amine is also disclosed. The process comprises reacting an unsaturated heterocyclic amine with hydrogen in a vapour phase reaction at a pressure of not more than 70 bar and a temperature in the range of from 150° C. to 350° C. A process of N-alkylating a saturated heterocyclic amine is also disclosed.
    Type: Application
    Filed: June 26, 2019
    Publication date: August 19, 2021
    Inventors: Paul GORDON, Steve POLLINGTON, John SWINNEY, Michael David HAMLIN, Steven James COLLIER
  • Patent number: 10450251
    Abstract: There is described a method of preparing a compound of formula I, and optical isomers thereof; in which R1 is hydrogen or a protecting group; said method comprising oxidizing verbenone and optical isomers thereof.
    Type: Grant
    Filed: December 2, 2016
    Date of Patent: October 22, 2019
    Assignee: E-THERAPEUTICS PLC
    Inventors: Vijaya Bhasker Gondi, James Thomson Loch, III, Nicholas John Holman, Steven James Collier
  • Publication number: 20180354876
    Abstract: There is described a method of preparing a compound of formula I, and optical isomers thereof; in which R1 is hydrogen or a protecting group; said method comprising oxidising verbenone and optical isomers thereof.
    Type: Application
    Filed: December 2, 2016
    Publication date: December 13, 2018
    Applicant: e-Therapeutics plc
    Inventors: Vijaya Bhasker Gondi, James Thomson Loch, III, Nicholas John Holman, Steven James Collier
  • Patent number: 8877475
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
    Type: Grant
    Filed: September 11, 2012
    Date of Patent: November 4, 2014
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt Huisman, Steven James Collier
  • Patent number: 8846362
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: January 31, 2013
    Date of Patent: September 30, 2014
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
  • Patent number: 8673607
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)-N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: March 18, 2014
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt W. Huisman, Steven James Collier
  • Patent number: 8426178
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2- thienyl)-1-propanamine.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: April 23, 2013
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt Huisman, Steven James Collier
  • Patent number: 8383382
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: February 26, 2013
    Assignee: Codexis, Inc.
    Inventors: Lynne Gilson, Steven James Collier, Joly Sukumaran, Wan Lin Yeo, Oscar Alvizo, Ee Ling Teo, Robert John Wilson, Junye Xu
  • Publication number: 20130005017
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
    Type: Application
    Filed: September 11, 2012
    Publication date: January 3, 2013
    Applicant: CODEXIS, INC.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt Huisman, Steven James Collier
  • Patent number: 8288141
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
    Type: Grant
    Filed: August 27, 2009
    Date of Patent: October 16, 2012
    Assignee: Codexis, Inc.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt Huisman, Steven James Collier
  • Publication number: 20120244582
    Abstract: Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
    Type: Application
    Filed: September 24, 2010
    Publication date: September 27, 2012
    Applicant: CODEXIS, INC.
    Inventors: Steven James Collier, Ee Ling Teo, Joly Sukumaran, Robert John Wilson, Junye Xu
  • Publication number: 20110111468
    Abstract: The present disclosure provides acyltransferases useful for synthesizing therapeutically important statin compound
    Type: Application
    Filed: September 24, 2010
    Publication date: May 12, 2011
    Applicant: Codexis, Inc.
    Inventors: Lynne GILSON, Steven James COLLIER, Joly SUKUMARAN, Wan Lin YEO, Oscar ALVIZO, Ee Ling TEO, Robert John WILSON, Junye XU
  • Publication number: 20110053941
    Abstract: Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer compris
    Type: Application
    Filed: December 1, 2008
    Publication date: March 3, 2011
    Applicant: NEWLINK GENETICS
    Inventors: Mario Mautino, Firoz Jaipuri, Agnieszka Marcinowicz-Flick, Tanay Kesharwani, Jesse Waldo, Steven James Collier
  • Publication number: 20100299100
    Abstract: A method of determining velocity of a shaft is provided. The method includes receiving a first shaft position signal and a second shaft position signal. Derivatives of each of the first shaft position signal and the second shaft position signal are computed, as are squares of each of the derivatives, a summation of the squares, and a square root of the summation. The velocity is output as a result of the square root.
    Type: Application
    Filed: December 31, 2008
    Publication date: November 25, 2010
    Applicant: GM GLOBAL TECHNOLOGYOPERATIONS, INC.
    Inventors: Philip G. Bright, Steven James Collier-Hallman
  • Publication number: 20100173369
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N-methyl-3-keto-3-(2-thienyl)-1-propanamine to (S)—N-methyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
    Type: Application
    Filed: August 27, 2009
    Publication date: July 8, 2010
    Applicant: CODEXIS, INC.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt Huisman, Steven James Collier
  • Publication number: 20100151534
    Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds. The engineered ketoreductase polypeptides are optimized for catalyzing the conversion of N,N-dimethyl-3-keto-3-(2-thienyl)-1-ketopropanamine to (S)—N,N-dimethyl-3-hydroxy-3-(2-thienyl)-1-propanamine.
    Type: Application
    Filed: August 27, 2009
    Publication date: June 17, 2010
    Applicant: CODEXIS, INC.
    Inventors: Christopher Savile, John M. Gruber, Emily Mundorff, Gjalt Huisman, Steven James Collier
  • Patent number: 7190135
    Abstract: A method for implementing control signal linearization for an electric motor is disclosed. In an exemplary embodiment, the method includes receiving a desired voltage command to be applied to the motor and determining whether the magnitude of the desired voltage command falls between a first value and a second value. If the magnitude of the desired voltage command falls between the first value and the second value, then modulating a voltage command between the first and the second value over a determined sample period, thereby resulting in the application of a modulated voltage command to the motor.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: March 13, 2007
    Assignee: Delphi Technologies, Inc.
    Inventor: Steven James Collier-Hallman
  • Patent number: 7157878
    Abstract: A method for controlling a voltage mode controlled electric machine comprising: receiving a torque value representative of a desired torque; obtaining a speed value indicative of a rotational velocity of the electric machine; acquiring a phase advance value indicative of a desired phase advance angle; generating a voltage command responsive to the torque value, the position value; the generating is responsive to the torque value, the speed value, and the phase advance value.
    Type: Grant
    Filed: November 19, 2002
    Date of Patent: January 2, 2007
    Assignee: Delphi Technologies, Inc.
    Inventor: Steven James Collier-Hallman
  • Patent number: 7075290
    Abstract: A method and apparatus for determining the velocity of a rotating device is described herein. The apparatus includes a magnet assembly affixed to a rotating shaft of a rotating device and a circuit assembly. The circuit assembly includes a circuit interconnection having a sense coil and sensors affixed thereto. The circuit assembly is adapted to be in proximity to the magnet assembly, wherein the magnet assembly combines with the circuit assembly to form an air core electric machine such that voltages generated from the sense coil exhibits an amplitude proportional to the velocity.
    Type: Grant
    Filed: July 26, 2002
    Date of Patent: July 11, 2006
    Assignee: Delphi Technologies, Inc.
    Inventors: Steven James Collier-Hallman, Philip G. Bright, Clane J. Cammin, Hentianarisoa Ratouth
  • Patent number: 6791217
    Abstract: A method and system for determining the velocity of a rotating device is described herein. The system includes an apparatus with a set of sense magnets affixed to a rotating shaft of the rotating device and a circuit assembly. The circuit assembly includes a circuit interconnection having a plurality of sense coils and sensors affixed thereto. The circuit assembly is adapted be in proximity to the set of sense magnets on the rotating part. A controller is coupled to the circuit assembly, where the controller executes an adaptive algorithm that determines the velocity of the rotating device. The algorithm is a method of combining a derived velocity with a velocity from the tachometer.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: September 14, 2004
    Assignee: Delphi Technologies, Inc.
    Inventors: Steven James Collier-Hallman, William J Bressette