Abstract: This invention relates to polynucleotides comprising optimized SLC13A5 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a SLC13A5 gene or aberrant activity of a SLC13A5 gene product in the subject, such as citrate transporter disorder.

Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.

Abstract: This invention relates to polynucleotides comprising UBE3A open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a UBE3A gene or aberrant activity of a UBE3A gene product in the subject, such as Angelman Syndrome.

Abstract: This invention relates to polynucleotides comprising optimized SUMF1 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for deliver) of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a SUMF1 gene or aberrant activity of a SUMF1 gene product in the subject, such as SUMF1 disease.

Abstract: This invention relates to polynucleotides comprising optimized GALC open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a GALC gene or aberrant activity of a GALC gene product in the subject, such as Krabbe disease (i.e., globoid cell leukodystrophy (GLD)).

Abstract: This invention relates to polynucleotides comprising optimized FIG4 open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a FIG4 gene or aberrant activity of a FIG4 gene product in the subject, such as CMT4J.

Abstract: This invention relates to polynucleotides comprising optimized aspartylglucosaminidase (AGA) open reading frames and vectors and cells comprising the same. The invention further relates to methods of using the same for delivery of the open reading frame to a cell or a subject and methods for treating aspartylglucosaminuria (AGU) in a subject.

Abstract: This invention relates to polynucleotides comprising optimized CLN7 open reading frame (ORF) sequences, viral vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of CLN7, such as variant late infantile neuronal ceroid lipofuscinoses (vLINCL; CLN7 disease).

Abstract: This invention relates to polynucleotides comprising optimized CLNS open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a CLNS gene or aberrant activity of a CLNS gene product in the subject, such as CLNS disease.

Abstract: This invention relates to feedback-enabled synthetic genes, polynucleotide target cassettes, vectors, and pharmaceutical compositions for the purpose of providing transgene expression in target tissues that is capable of endogenous regulation for treating disorders such as dose-sensitive intellectual ability disorders, as well as methods of making and methods of using the same.

Abstract: Approaches for assessing hemodynamic characteristics for an organ of interest are related. In one implementation, a fluid dynamics model may be provided with data derived from an anatomic imaging modality and blood flow information derived by ultrasound to derive the desired hemodynamic characteristics. In one such implementation, a fractional flow reserve is estimated.

Abstract: Approaches for assessing hemodynamic characteristics for an organ of interest are related. In one implementation, a fluid dynamics model may be provided with data derived from an anatomic imaging modality and blood flow information derived by ultrasound to derive the desired hemodynamic characteristics. In one such implementation, a fractional flow reserve is estimated.

Abstract: A method for determining the configuration of a diesel powered system having at least one diesel-fueled power generating unit, the method including a step for determining a minimum power required from the diesel powered system in order to accomplish a specified mission, and a step for determining an operating condition of the diesel-fueled power generating unit such that the minimum power requirement is satisfied while yielding at least one of lower fuel consumption and lower emissions for the diesel powered system.

Abstract: Approaches for assessing hemodynamic characteristics for an organ of interest are related. In one implementation, a fluid dynamics model may be provided with data derived from an anatomic imaging modality and blood flow information derived by ultrasound to derive the desired hemodynamic characteristics. In one such implementation, a fractional flow reserve is estimated.

Abstract: Approaches for assessing hemodynamic characteristics for an organ of interest are related. In one implementation, a fluid dynamics model may be provided with data derived from an anatomic imaging modality and blood flow information derived by ultrasound to derive the desired hemodynamic characteristics. In one such implementation, a fractional flow reserve is estimated.

Abstract: A method is provided including determining a first power level required from a diesel powered system. The first power level corresponds to a first proportion of a maximum power. The method also includes determining an emission output for a mission based on the first power level. The method further includes determining a second power level corresponding to a second proportion of the maximum power, wherein alternate use of the second power level and at least one of the first power level or a third power level results in a lower emission output for the mission, with the overall resulting power being proximate the minimum power required. The method also includes automatically controlling operation of the diesel powered system by using the second power level alternately with at least one of the first power level or the third power level.

Abstract: A method is provided including determining a first power level required from a diesel powered system. The first power level corresponds to a first proportion of a maximum power. The method also includes determining an emission output for a mission based on the first power level. The method further includes determining a second power level corresponding to a second proportion of the maximum power, wherein alternate use of the second power level and at least one of the first power level or a third power level results in a lower emission output for the mission, with the overall resulting power being proximate the minimum power required. The method also includes automatically controlling operation of the diesel powered system by using the second power level alternately with at least one of the first power level or the third power level.

Abstract: A method for operating a diesel powered system having at least one diesel-fueled power generating unit, the method including evaluating an operating characteristic of the diesel powered system, comparing the operating characteristic to a desired value to satisfy a mission objective, and adjusting the operating characteristic to correspond to the desired value with a closed-loop control system that operates on a feedback principle to satisfy a mission objective. A system and a computer software code are also disclosed for operating a diesel powered system having at least one diesel-fueled power generating unit.

Abstract: A method for minimizing emission output from a diesel powered system having at least one diesel-fueled power generating unit, the method including determining at least one power level required from the diesel powered system in order to accomplish a specified mission, determining an emission output based on the power level required, and using at least one other power level that results in a lower emission output wherein the overall resulting power is proximate the power required.

Abstract: A method for determining the configuration of a diesel powered system having at least one diesel-fueled power generating unit, the method including a step for determining a minimum power required from the diesel powered system in order to accomplish a specified mission, and a step for determining an operating condition of the diesel-fueled power generating unit such that the minimum power requirement is satisfied while yielding at least one of lower fuel consumption and lower emissions for the diesel powered system.