Abstract: Aspects of the instant disclosure relate to an orthosis pressure sensing device and methods of use. The pressure sensing device utilizes a Control unit connected to at least one pressure sensing arrangement placed in proximity to an orthosis. The control unit collects data from the pressure sensing arrangement, and wirelessly communicates data to various remote devices, which may be useful for improving a patient's gait, wound recovery or overall function. Each pressure sensor arrangement has a pressure sensor designed for selective placement at multiple locations of interest that include different contact points between an orthosis and a patient.