Patents by Inventor Steven Joel Brown

Steven Joel Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oligonucleotides and methods for inhibiting cellular proliferation
    Patent number: 5945336
    Abstract: The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
    Type: Grant
    Filed: November 21, 1997
    Date of Patent: August 31, 1999
    Assignee: Gen-Probe Incorporated
    Inventors: Steven Joel Brown, Nanibhushan Dattagupta, Yathi M. Naidu
  • Compositions and methods for screening drug libraries
    Patent number: 5866341
    Abstract: A method of screening for binding partners of a specific molecule. The method employs a chimeric protein having at least two different binding regions; one containing at least a portion of the specific molecule or an analog thereof, and the other containing a binding region of an immunoglobulin chain. In a preferred embodiment, the method is used for rapidly screening member compounds of a combinatorial library for potential biological activity.
    Type: Grant
    Filed: April 3, 1996
    Date of Patent: February 2, 1999
    Assignee: Chugai Pharmaceutical Co., Ltd.
    Inventors: Dominic Gregory Spinella, Kathleen Ann Becherer, Steven Joel Brown
  • Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
    Patent number: 5716846
    Abstract: The present invention relates to methods of treating disease-associated cellular proliferation using oligonucleotides. In particular, it relates to the use of oligonulceotides which are substantially complementary to interleukin-6 receptor mRNA sequences. In the form of pharmaceutical compositions, these oligonucleotides are suitable for administration to human subjects for the treatment of abnormal cellular proliferation due to such diseases as cancer, autoimmune disorders and viral infection.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 10, 1998
    Assignee: Gen-Probe Incorporated
    Inventors: Steven Joel Brown, Nanibhushan Dattagupta, Yathi M. Naidu