Abstract: The invention provides compounds of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length of 5 atoms extending between R1 and NR2R3 and a maximum chain length of 4 atoms extending between E and NR2R3, wherein one of the carbon atoms in the linker group may optionally be replaced by an oxygen or nitrogen atom; and wherein the carbon atoms of the linker group A may optionally bear one or more substituents selected from oxo, fluorine and hydroxy, provided that the hydroxy group when present is not located at a carbon atom ? with respect to the NR2R3 group and provided that the oxo group when present is located at a carbon atom ? with respect to the NR2R3 group; E is a monocyclic or bicyclic carbocyclic or heterocyclic group; R1 is an aryl or heteroaryl group; and R2, R3, R4 and R5 are as defined in the claims.

Abstract: Aspects relate to arbitrating access to an interconnect among multiple ports. For example, input ports receive requests for access to identified destination ports and buffer these in one or more FIFOs. A picker associated with respective FIFO(s) begins an empty arbitration packet that includes a location for each output port and fills one or more locations in the packet, such as based on a prioritization scheme. Each packet is passed in a ring to another picker, which performs a fill that does not conflict with previously filled locations in that packet. Each picker has an opportunity to place requests in each of the packets. Results of the arbitration are dispatched to reorder buffers associated with respective output ports and used to schedule the interconnect. Each arbitration cycle thus produces a set of control information for an interconnect to be used in subsequent data transfer steps.

Abstract: A building panel having a hollow elongate structure with a generally rectangular cross-sectional profile. The elongate structure has first and second outer skins joined by parallel first and second side walls. A connection device of first and second ribs is on each side wall to connect to adjacent panels to form a segment of a wall or roof. The elongate structure includes two inner web skins extending between the first and second side walls to divide the interior of the elongate structure into three chambers. The triple chamber profile provides the panel with additional structural strength and rigidity, as well as improved thermal and sound insulation properties. The lower chamber may be fitted with a polycarbonate sheet to increase thermal and acoustic performance. The panel is polycarbonate.

Abstract: Exemplary methods and systems relate to the handling of a communication request by a wearable computing device. For example, a wearable computing device may respond to communication requests by sharing real-time media that portrays the device's surroundings and the activity of a user associated with the device. The wearable device or a server system communicatively linked to the wearable device may perform the reception and transmission functions. This process may proceed automatically or as a result of user-input and may additionally involve procedures for accepting or rejecting the communication request.

Abstract: Methods and apparatus to determine media impressions using distributed demographic information are disclosed. An method includes sending to a client computer, via a processor serving a first internet domain, a response to a first request, the first request sent to the first internet domain and indicative of access to media at the client computer, the response to instruct the client computer to send a second request to an intermediary serving a sub-domain of a second internet domain, the second request to be indicative of the access to the media at the client computer, wherein the intermediary is to transmit first data about the second request to a data collection server of an audience measurement entity and second data about the second request to an entity of the second internet domain and logging an impression of the media.

Abstract: Fabrics having fiber blends and constructions engineered to enhance the ballistic protection as well as the comfort and/or dyeability/printability of such fabrics.

Abstract: The present invention relates to pyrrolopyrazines compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.

Abstract: Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for producing 3-HP and other organic compounds are disclosed.

Abstract: When constructing a nuclear detector module in a gantry, a plurality of overlapping light guide modules (10) are mounted to the gantry in a spaced-apart fashion, and a plurality of underlapping light guide modules (12) are mounted in between each pair of overlapping light guide modules (10). Each of the underlapping modules and the overlapping modules includes a scintillation crystal array (16) on an interior surface thereof, and a plurality of PMTs on an exterior surface thereof. Overlapping modules (10) have overlapping structures (22) that interface with underlapping structures (18) on the underlapping modules (12) and thereby eliminate a seam directly beneath PMTs that overlap the crystal arrays of both an overlapping module and an underlapping module. Optical grease is used to form a resilient grease coupling and reduce light scatter between the underlapping and overlapping modules.

Abstract: The present invention provides heterocyclic derivatives which activate the IP receptor. Activating the IP receptor signaling pathway is useful to treat many forms of PAH, pulmonary fibrosis and exert beneficial effects in fibrotic conditions of various organs in animal models and in patients. Pharmaceutical compositions comprising such derivatives are also encompassed. Examples of compounds of the invention include the compounds according to Formula Ia, or a pharmaceutically acceptable salt thereof, and the compounds of the examples.

Abstract: A technique for handling user-interface gestures in non-rectangular regions of a graphical user interface includes creating a class comprising an event handler for an onmouseover event and an event handler for an onmouseout event. The technique further includes adding each of a group of graphical elements to the class. Adding a graphical element to the class includes adding a reference to the graphical element to the class and attaching the event handlers to the graphical element. The technique then identifies a specific graphical element in the group that triggered an invocation of one of the event handlers. The technique then determines the closest border of the specific graphical element to the mouse pointer. In the event another graphical element in the group shares the closest border, the technique stops either the onmouseover or onmouseout event from propagating.

Abstract: The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N?C(R6), (R7)C?N, (R8)N—C(O), (R8)2C—C(O), N?N or (R7)C?C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4 alkylene chain linked to R1 or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the

Abstract: The present technology provides an apparatus and a method for transmitting data via two or more FM signals in an interference avoiding manner. The apparatus comprises at least two FM transmitters. Each FM transmitter is configured to transmit a FM signal on a particular FM channel characterized by a certain carrier frequency that includes data and optionally one or more corresponding alternative frequencies (AFs). The apparatus further includes at least two receivers for receiving incoming electromagnetic radiation (EMR). At least one of the receivers is configured to receive incoming EMR associated with at least one of the FM channels, and another is configured to receive incoming EMR at least at frequencies outside of the FM channels. The controller is configured to separately control activation and deactivation of the FM transmitters and determine the carrier frequencies and the one or more AFs based upon incoming EMR.

Abstract: The present invention concerns Capsicum annuum plants producing pepper fruits, exhibiting new physicochemical characteristics of the pepper fruit in relation with chlorophyll A & B, lutein as well as violaxanthin. The pepper fruits of the plants according to the present invention also exhibit a characteristic extreme dark green color at immature stage which color is linked to the content in pigment of the said fruit. The present invention also relates to QTL alleles directing the expression of the pigment content of those pepper fruits as well as molecular markers associated with these QTL alleles.

Abstract: The present invention is directed to a system and method for managing state information related to an interactive application to accommodate one or more users participating in an interactive application session, wherein the state information comprises local state information specific to each of the one or more user's unique view of the interactive application and global state information. The system of the present invention may comprise a telecommunications network; an application server in communication with the telecommunications network for managing the global state information relative to all of the users participating in the interactive application session; and at least one mobile client device in communication with the application server over the telecommunications network for managing the local state information for each of the one or more users.

Abstract: Creating and processing a natural language grammar set of data based on an input text string are disclosed. The method may include tagging the input text string, and examining, via a processor, the input text string for at least one first set of substitutions based on content of the input text string. The method may also include determining whether the input text string is a substring of a previously tagged input text string by comparing the input text string to a previously tagged input text string, such that the substring determination operation determines whether the input text string is wholly included in the previously tagged input text string.

Abstract: The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein A1, A2, A3, L1, L2 and D are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the Compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

Abstract: System(s), device(s), and method(s) provide bi-directional mechanisms for binding graphic element definitions to industrial automation data types in an industrial control system. Moreover, a system that automatically provides data searching and filtering of an item based on user interactions with either the graphic element definition or a controller data type is provided. Further, a graphic element definition is associated with a data source type information, to simplify configuration of an instance of that graphic element and populate suitable data source fields based on instances of the associated data source type. In addition, a system to automatically generate the graphic element based on data from a logic controller is provided. Moreover, the graphic element can be updated to reflect a change in the data, without a manual refresh.

Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

Abstract: The present invention provides a secondary cooling apparatus and method of providing cooling to one or more features in a refrigerator. In one exemplary aspect of the present invention, the refrigerator includes a cabinet having a door, a first cooling loop in the cabinet, and a second cooling loop cooled by the first cooling loop. The secondary cooling loop is adapted to cool the one or more features in the cabinet or on the door of the refrigerator. In another exemplary aspect of the present invention, a method for providing cooling in a refrigerator to one or more features in a compartment or on a door of the refrigerator includes providing a first cooling loop within a refrigerator, cooling a secondary cooling loop directly or indirectly with the first cooling loop, and transferring cooling from the secondary cooling loop to the one or more features in the compartment or on the door of the refrigerator.