Abstract: A method of assigning parent-of-origin to a haplotype, a sub-haplotype or an allele associated with a haplotype. Chromosome-length haplotypes of a genome are generated and a differential methylation status of at least one imprinted differentially methylated region (iDMR) associated with each one of the autosomal chromosomes is determined. The differential methylation status of the at least one iDMR is used to assign parent-of-origin for each one of the chromosome-length haplotypes.

Abstract: A method of manufacturing a monolithic vessel head with integral tube attachments is disclosed. The method includes the steps of forging a vessel head; boring at least one penetration in the vessel head; and inserting a tube into the at least penetration and using a solid-state joining process to join the tube to the vessel head.

Abstract: The disclosure provides oral pouched products including a fleece material with a controlled basis weight. In some embodiments, the oral pouched products may include a material within a porous pouch, wherein the porous pouch includes a fleece material having a basis weight of at least about 35 gsm. In some embodiments, the oral pouched products may include fleece materials have a thickness of at least about 0.2 mm or less than about 0.1 mm. In some embodiments, the pouched products may be configured for rapid or extended release of components contained therein or may be tailored to provide a desired release profile.

Abstract: A method of assigning parent-of-origin to a haplotype, a sub-haplotype or an allele associated with a haplotype. Chromosome-length haplotypes of a genome are generated and a differential methylation status of at least one imprinted differentially methylated region (iDMR) associated with each one of the autosomal chromosomes is determined. The differential methylation status of the at least one iDMR is used to assign parent-of-origin for each one of the chromosome-length haplotypes.

Abstract: The disclosure provides oral products, the oral products including a fleece material that includes fibers and a releasable component. In some embodiments, oral products as described herein may be in the form of a pouchless product including a fleece material having a releasable component associated therewith, or in the form of a pouched product including a fleece material having a releasable component associated therewith in the form of a pouch, containing a substrate material therein.

Abstract: The disclosure provides oral pouched products including a fleece material with a controlled basis weight. In some embodiments, the oral pouched products may include a material within a porous pouch, wherein the porous pouch includes a fleece material having a basis weight of at least about 35 gsm. In some embodiments, the oral pouched products may include fleece materials have a thickness of at least about 0.2 mm or less than about 0.1 mm. In some embodiments, the pouched products may be configured for rapid or extended release of components contained therein or may be tailored to provide a desired release profile.

Abstract: The disclosure provides oral products, the oral products including a fleece material that includes fibers and a releasable component. In some embodiments, oral products as described herein may be in the form of a pouchless product including a fleece material having a releasable component associated therewith, or in the form of a pouched product including a fleece material having a releasable component associated therewith in the form of a pouch, containing a substrate material therein.

Abstract: A layered control panel for a heating, ventilation, air conditioning, and refrigeration (HVACR) unit includes an outer layer on which low-voltage components are placed, and an inner layer on which high-voltage components are placed. The outer layer is capable of taking a closed position where it blocks access to the inner layer, and an open position where the outer layer does not block access to the inner layer. The outer layer can include a lock to keep the outer layer in the closed position. The outer layer can be one or two or more panels mounted on hinges that allow the outer layer to swing between closed and open positions.

Abstract: The present disclosure provides components of packaging that is adapted for storing a product including a container having a body and a cover. The body and the cover define an internal storage compartment adapted for storage of a product. The body is configured to interact with the cover so as to form a joint when engaged. A sealing member is configured to substantially cover the joint, wherein the material of the sealing member is continuous and uninterrupted, thus limiting moisture loss from a product within the internal storage compartment. The sealing member is further configured to tear in a direction that is substantially parallel to the joint of the container.

Abstract: A method of assigning parent-of-origin to a haplotype, a sub-haplotype or an allele associated with a haplotype. Chromosome-length haplotypes of a genome are generated and a differential methylation status of at least one imprinted differentially methylated region (iDMR) associated with each one of the autosomal chromosomes is determined. The differential methylation status of the at least one iDMR is used to assign parent-of-origin for each one of the chromosome-length haplotypes.

Abstract: A computer-implemented method of determining a demographic associated with a viewer that watches a selected video is provided. The method includes receiving, at a computing device having one or more processors, video data including applied data and referral data. The applied data includes metadata that describes content of a first collection of videos. The referral data includes data associated with a second collection of videos that were previously viewed before the selected video and referred to the selected video. A taxonomy of content is generated that classifies an audience type of the video data. An audience model is generated based on the taxonomy. The audience model has a dataset related to at least one of age and gender of the viewer that watches the selected video. An affinity of the viewer toward a particular video is determined based on the taxonomy of the content.

Abstract: The present disclosure provides filter materials adapted for use as a filter element in an aerosol delivery device and methods of forming such filter materials suitable for use as a filter element in such devices. The disclosure provides, in some embodiments, a filter material which includes a plurality of fibers selected from the group consisting of regenerated cellulose, hemp, sisal, esparto, kenaf, jute, flax, wood, reconstituted tobacco, and combinations thereof, wherein the filter material is in the form of a nonwoven sheet or a fibrous tow.

Abstract: A layered control panel for a heating, ventilation, air conditioning, and refrigeration (HVACR) unit includes an outer layer on which low-voltage components are placed, and an inner layer on which high-voltage components are placed. The outer layer is capable of taking a closed position where it blocks access to the inner layer, and an open position where the outer layer does not block access to the inner layer. The outer layer can include a lock to keep the outer layer in the closed position. The outer layer can be one or two or more panels mounted on hinges that allow the outer layer to swing between closed and open positions.

Abstract: An oral product in the form of an edible film is provided herein. The edible film can include a binder in an amount of at least about 30 percent by weight; a plasticizer in an amount of at least about 5 percent by weight; and an active agent, wherein the edible film is orally dissolvable. The edible film can also be used as a component of another oral product, e.g., a fleece-based pouched product. The edible film can form a coating on a portion of an interior or exterior surface of a fleece-based pouched product.

Abstract: A pouched product adapted for release of a water-soluble component therefrom is provided herein. The pouched product can include an outer water-permeable pouch defining a cavity containing a composition that includes a water-soluble component capable of being released through the water-permeable pouch and has a surface area, wherein the outer water-permeable pouch can include a nonwoven web including fibers, wherein at least a portion of the fibers are selected from the group consisting of polyester fibers in an amount of 20% or greater based on the total weight of the fibers, tobacco-derived viscose, sisal fibers, corn silk fibers, long wood fibers, MCC fibers, and combinations thereof.

Abstract: The disclosure provides pouched products configured for oral use, including a material within a porous pouch, where the porous pouch has four sides of small dimension, where the porous pouch has four sides of large dimension, and/or wherein the porous pouch has a shape other than square or rectangular, e.g., a rounded shape. The disclosure further provides methods of providing a modified mouthfeel with respect to conventional pouched products by providing pouched product in such sizes and/or shapes.