Abstract: A multiple grip handle for dental and other hand-held oral hygiene implements, the handle being adapted to render the implement to which it is applied useable by individuals who have difficulty in firmly grasping a conventional oral hygiene implement handle, difficulty manipulating and stabilizing a handle during oral hygiene, or by individuals who have varying types of preferred grips. The multiple grip handle in the preferred embodiment is fabricated of thermoplastic with an elastomeric coating material having good cushioning, non-slipping, and antimicrobial properties. The handle also has a variable elliptical cross section, a central cavity to socket a brush neck or other equipment, a unique thumb/knuckle grip on the dorsal surface, a plurality of gripping elements on the ventral surface, and an extended distal portion to afford fine control, comfort and stability for whatever gripping style the user prefers.