Patents by Inventor Steven K. Davidsen

Steven K. Davidsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of histone deacetylase
    Publication number: 20020177594
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: October 26, 2001
    Publication date: November 28, 2002
    Inventors: Michael L. Curtin, Yujia Dai, Steven K Davidsen, Robin R. Frey, Yan Guo, Howard R. Heyman, James H. Holms, Zhiqin Ji, Michael R. Michaelides, Anil Vasudevan, Carol K. Wada
  • Inhibitors of histone deacetylase
    Publication number: 20020103192
    Abstract: Substituted trifluoromethyl ketones, ketooxazoles, ketoamides, ketoesters, and diketones having the formula 1
    Type: Application
    Filed: March 14, 2001
    Publication date: August 1, 2002
    Inventors: Michael L. Curtin, Steven K. Davidsen, Robin R. Frey, Howard R. Heyman, Michael R. Michaelides, Anil Vasudevan, Carol K. Wada
  • Reverse hydroxamate inhibitors of matrix metalloproteinases
    Publication number: 20020007060
    Abstract: Compounds having the formula 1
    Type: Application
    Filed: July 16, 2001
    Publication date: January 17, 2002
    Inventors: Steven K. Davidsen, Michael L. Curtin, Joseph F. Dellaria, Alan S. Florjancic, Jamie Giesler-Stacy, Jianchung Gong, Yan Guo, H. Robin Heyman, James H. Holms, Michael R. Michaelides, Douglas Steinman, Carol K. Wada, Lianhong Xu
  • Reverse hydroxamate inhibitors of matrix metalloproteinases
    Patent number: 6294573
    Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: September 25, 2001
    Assignee: Abbott Laboratories
    Inventors: Michael L. Curtin, Yujia Dai, Steven K. Davidsen, Joseph F. Dellaria, Jr., Alan S. Florjancic, Jianchun Gong, Yan Guo, Howard R. Heyman, James H. Holms, Michael R. Michaelides, Jamie R. Stacey, Douglas H. Steinman, Carol K. Wada, Lianhong Xu
  • Inhibitors of matrix metalloproteinases
    Patent number: 6288261
    Abstract: Compounds having the formula and pharmaceutically acceptable salts and prodrugs thereof are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: September 11, 2001
    Assignee: Abbott Laboratories
    Inventors: David J. Augeri, David A. Betebenner, Richard Craig, Steven K. Davidsen, Stephen W. Fesik, Jamie R. Giesler-Stacey, Yan Guo, Philip J. Hajduk, Michael R. Michaelides, David G. Nettesheim
  • Reverse hydroxamate inhibitors of matrix metalloproteinases
    Patent number: 6235786
    Abstract: Compounds having the formula are matrix metalloproteinase inhibitors. Also disclosed are matrix metalloproteinase-inhibiting compositions and methods of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: May 22, 2001
    Assignee: Abbott Laboratories
    Inventors: Yujia Dai, Steven K. Davidsen, Michael R. Michaelides, Jamie R. Stacey, Douglas H. Steinman, Carol K. Wada
  • C-terminal ketone inhibitors of matrix metalloproteinases and TNF.alpha. secretion
    Patent number: 5985911
    Abstract: C-terminal compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: November 16, 1999
    Assignee: Abbott Laboratories
    Inventors: Steven K. Davidsen, Alan S. Florjancic, George S. Sheppard, Jamie R. Giesler, Lianhong Xu, Yan Guo, Michael L. Curtin, Michael R. Michaelides, Carol K. Wada, James H. Holms
  • Macrocyclic inhibitors of matrix metalloproteinases and TNF.alpha. secretion
    Patent number: 5952320
    Abstract: Macrocyclic compounds of formula ##STR1## are potent inhibitors of matrix metalloproteinase and are useful in the treatment of diseases in which matrix metalloproteinase play a role. Also disclosed are matrix metalloproteinase inhibiting compositions and a method of inhibiting matrix metalloproteinase in a mammal.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: September 14, 1999
    Assignee: Abbott Laboratories
    Inventors: Steven K. Davidsen, Douglas H. Steinman, George S. Sheppard, Lianhong Xu, James H. Holms, Yan Guo, James B. Summers, Alan S. Florjancic, Michael R. Michaelides
  • Biphenyl hydroxamate inhibitors of matrix metalloproteinases
    Patent number: 5665777
    Abstract: Compounds of formula ##STR1## or a pharmaceutically acceptable salt thereof inhibit matrix metalloproteinases and TNF.alpha. secretion and are useful in the treatment of inflammatory disease states. Also disclosed are matrix metalloproteinases and TNF.alpha. secretion inhibiting compositions and a method for inhibiting matrix metalloproteinases and TNF.alpha. secretion.
    Type: Grant
    Filed: November 14, 1995
    Date of Patent: September 9, 1997
    Assignee: Abbott Laboratories
    Inventors: Stephen W. Fesik, James B. Summers, Jr., Steven K. Davidsen, George S. Sheppard, Douglas H. Steinman, George M. Carrera, Jr., Alan Florjancic, James H. Holms
  • Indole piperazine platelet activating factor antagonists
    Patent number: 5654305
    Abstract: The present invention provides compounds of formula ##STR1## wherein Y is >C.dbd.O or >S(O).sub.t wherein t is 1 or 2 and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, rhinitis, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: August 5, 1997
    Assignee: Abbott Laboratories
    Inventors: George S. Sheppard, Steven K. Davidsen, James B. Summers, George M. Carrera, Jr.
  • Indole cyclohexyl platelet activating factor antagonists
    Patent number: 5643922
    Abstract: The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, rhinitis, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: July 2, 1996
    Date of Patent: July 1, 1997
    Assignee: Abbott Laboratories
    Inventors: George S. Sheppard, Steven K. Davidsen, James B. Summers
  • Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists
    Patent number: 5567711
    Abstract: The present invention provides compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: October 22, 1996
    Assignee: Abbott Laboratories
    Inventors: George S. Sheppard, Steven K. Davidsen, James B. Summers, George M. Carrera, Jr.
  • Platelet activating factor antagonists: imidazopyridine indoles
    Patent number: 5486525
    Abstract: The present invention relates to compounds of formula ##STR1## and the pharmaceutically acceptable salts thereof which are potent antagonists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointestinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: January 23, 1996
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Jr., Steven K. Davidsen, Michael L. Curtin, H. Robin Heyman, George S. Sheppard, Lianhong Xu, George M. Carrera, Jr., Robert B. Garland
  • Platelet activating factor antagonists
    Patent number: 5459152
    Abstract: Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: December 2, 1993
    Date of Patent: October 17, 1995
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Steven K. Davidsen, James H. Holms, Daisy Pireh, H. Robin Heyman, Michael B. Martin, Douglas H. Steinman, George S. Sheppard, George M. Carrera, Jr.
  • Platelet activating factor antagonists
    Patent number: 5382670
    Abstract: Indole compounds substituted at the 1- or 3-position by a (pyrid-3-yl)thiazolid-4-yl)alkyl-, (pyrid-3-yl)thiazolid-4-oyl)-, (pyrid-3-yl)dithiolan-4-yl)alkyl- or (pyrid-3-yl)dithiolan-4-oyl)- group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including septic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: July 7, 1993
    Date of Patent: January 17, 1995
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, George S. Sheppard, James G. Phillips, Daisy Pireh, Douglas H. Steinman, Paul D. May, Denise E. Guinn, H. Robin Heyman, George M. Carrera, Jr., Steven K. Davidsen
  • Platelet activating antagonists
    Patent number: 5149704
    Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl]urea-group are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: May 3, 1991
    Date of Patent: September 22, 1992
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Steven K. Davidsen, Douglas H. Steinman, James G. Phillips, Michael B. Martin, Denise E. Guinn
  • Benzoylphenyl pyridinylthiazolidine compounds as platelet activating antagonists
    Patent number: 5120751
    Abstract: Benzoylphenyl derivatives of 2-(3-pyridinyl)-3-alkyl-4-thiazolidinecarboxamide, 2-(3-pyridinyl)-thiazolid-4-ylacetamide, 2-(3-pyridinyl)-4-dithiolanecarboxamide or 2-(3-pyridinyl)dithiolan-4-yl] urea are potent inhibitors of PAF and are useful in the treatment of PAF-related disorders including anaphylactic shock, respiratory distress syndrome, acute inflammation, delayed cellular immunity, parturtition, fetal lung maturation, and cellular differentiation.
    Type: Grant
    Filed: March 29, 1991
    Date of Patent: June 9, 1992
    Assignee: Abbott Laboratories
    Inventors: James B. Summers, Douglas H. Steinman, Denise E. Guinn, Steven K. Davidsen, Paul D. May